Abnormal myofiber morphology and limb dysfunction in claudication

• Published in: The Journal of surgical research Vol. 196; no. 1; pp. 172 - 179
• Main Authors: Koutakis, Panagiotis, Myers, Sara A., Cluff, Kim, Ha, Duy M., Haynatzki, Gleb, McComb, Rodney D., Uchida, Koji, Miserlis, Dimitrios, Papoutsi, Evlampia, Johanning, Jason M., Casale, George P., Pipinos, Iraklis I.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2015
• Subjects: Aged; Claudication; Extremities - physiopathology; Female; Humans; Intermittent Claudication - pathology; Intermittent Claudication - physiopathology; Male; Middle Aged; Muscle Fibers, Skeletal - pathology; Muscle Strength; Myofiber morphology; Surgery; Walking distance; Walking distance; Claudication; Myofiber morphology

Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to the legs. Chronic, repeated ischemia in the lower leg muscles of PAD patients is associated with loss of normal myofiber morphology...