Abnormal myofiber morphology and limb dysfunction in claudication
Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to the legs. Chronic, repeated ischemia in the lower leg muscles of PAD patients is associated with loss of normal myofiber morphology...
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| Published in | The Journal of surgical research Vol. 196; no. 1; pp. 172 - 179 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.06.2015
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| Abstract | Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to the legs. Chronic, repeated ischemia in the lower leg muscles of PAD patients is associated with loss of normal myofiber morphology and myofiber degradation. In this study, we tested the hypothesis that myofiber morphometrics of PAD calf muscle are significantly different from normal calf muscle and correlate with reduced calf muscle strength and walking performance.
Gastrocnemius biopsies were collected from 154 PAD patients (Fontaine stage II) and 85 control subjects. Morphometric parameters of gastrocnemius fibers were determined and evaluated for associations with walking distances and calf muscle strength.
Compared with control myofibers, PAD myofiber cross-sectional area, major and minor axes, equivalent diameter, perimeter, solidity, and density were significantly decreased (P < 0.005), whereas roundness was significantly increased (P < 0.005). Myofiber morphometric parameters correlated with walking distances and calf muscle strength. Multiple regression analyses demonstrated myofiber cross-sectional area, roundness, and solidity as the best predictors of calf muscle strength and 6-min walking distance, whereas cross-sectional area was the main predictor of maximum walking distance.
Myofiber morphometrics of PAD gastrocnemius differ significantly from those of control muscle and predict calf muscle strength and walking distances of the PAD patients. Morphometric parameters of gastrocnemius myofibers may serve as objective criteria for diagnosis, staging, and treatment of PAD. |
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| AbstractList | Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to the legs. Chronic, repeated ischemia in the lower leg muscles of PAD patients is associated with loss of normal myofiber morphology and myofiber degradation. In this study, we tested the hypothesis that myofiber morphometrics of PAD calf muscle are significantly different from normal calf muscle and correlate with reduced calf muscle strength and walking performance.
Gastrocnemius biopsies were collected from 154 PAD patients (Fontaine stage II) and 85 control subjects. Morphometric parameters of gastrocnemius fibers were determined and evaluated for associations with walking distances and calf muscle strength.
Compared with control myofibers, PAD myofiber cross-sectional area, major and minor axes, equivalent diameter, perimeter, solidity, and density were significantly decreased (P < 0.005), whereas roundness was significantly increased (P < 0.005). Myofiber morphometric parameters correlated with walking distances and calf muscle strength. Multiple regression analyses demonstrated myofiber cross-sectional area, roundness, and solidity as the best predictors of calf muscle strength and 6-min walking distance, whereas cross-sectional area was the main predictor of maximum walking distance.
Myofiber morphometrics of PAD gastrocnemius differ significantly from those of control muscle and predict calf muscle strength and walking distances of the PAD patients. Morphometric parameters of gastrocnemius myofibers may serve as objective criteria for diagnosis, staging, and treatment of PAD. Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to the legs. Chronic, repeated ischemia in the lower leg muscles of PAD patients is associated with loss of normal myofiber morphology and myofiber degradation. In this study, we tested the hypothesis that myofiber morphometrics of PAD calf muscle are significantly different from normal calf muscle and correlate with reduced calf muscle strength and walking performance. Gastrocnemius biopsies were collected from 154 PAD patients (Fontaine stage II) and 85 control subjects. Morphometric parameters of gastrocnemius fibers were determined and evaluated for associations with walking distances and calf muscle strength. Compared with control myofibers, PAD myofiber cross-sectional area, major and minor axes, equivalent diameter, perimeter, solidity, and density were significantly decreased (P < 0.005), whereas roundness was significantly increased (P < 0.005). Myofiber morphometric parameters correlated with walking distances and calf muscle strength. Multiple regression analyses demonstrated myofiber cross-sectional area, roundness, and solidity as the best predictors of calf muscle strength and 6-min walking distance, whereas cross-sectional area was the main predictor of maximum walking distance. Myofiber morphometrics of PAD gastrocnemius differ significantly from those of control muscle and predict calf muscle strength and walking distances of the PAD patients. Morphometric parameters of gastrocnemius myofibers may serve as objective criteria for diagnosis, staging, and treatment of PAD. Abstract Background Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to the legs. Chronic, repeated ischemia in the lower leg muscles of PAD patients is associated with loss of normal myofiber morphology and myofiber degradation. In this study, we tested the hypothesis that myofiber morphometrics of PAD calf muscle are significantly different from normal calf muscle and correlate with reduced calf muscle strength and walking performance. Methods Gastrocnemius biopsies were collected from 154 PAD patients (Fontaine stage II) and 85 control subjects. Morphometric parameters of gastrocnemius fibers were determined and evaluated for associations with walking distances and calf muscle strength. Results Compared with control myofibers, PAD myofiber cross-sectional area, major and minor axes, equivalent diameter, perimeter, solidity, and density were significantly decreased ( P < 0.005), whereas roundness was significantly increased ( P < 0.005). Myofiber morphometric parameters correlated with walking distances and calf muscle strength. Multiple regression analyses demonstrated myofiber cross-sectional area, roundness, and solidity as the best predictors of calf muscle strength and 6-min walking distance, whereas cross-sectional area was the main predictor of maximum walking distance. Conclusions Myofiber morphometrics of PAD gastrocnemius differ significantly from those of control muscle and predict calf muscle strength and walking distances of the PAD patients. Morphometric parameters of gastrocnemius myofibers may serve as objective criteria for diagnosis, staging, and treatment of PAD. BACKGROUNDPeripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to the legs. Chronic, repeated ischemia in the lower leg muscles of PAD patients is associated with loss of normal myofiber morphology and myofiber degradation. In this study, we tested the hypothesis that myofiber morphometrics of PAD calf muscle are significantly different from normal calf muscle and correlate with reduced calf muscle strength and walking performance.METHODSGastrocnemius biopsies were collected from 154 PAD patients (Fontaine stage II) and 85 control subjects. Morphometric parameters of gastrocnemius fibers were determined and evaluated for associations with walking distances and calf muscle strength.RESULTSCompared with control myofibers, PAD myofiber cross-sectional area, major and minor axes, equivalent diameter, perimeter, solidity, and density were significantly decreased (P < 0.005), whereas roundness was significantly increased (P < 0.005). Myofiber morphometric parameters correlated with walking distances and calf muscle strength. Multiple regression analyses demonstrated myofiber cross-sectional area, roundness, and solidity as the best predictors of calf muscle strength and 6-min walking distance, whereas cross-sectional area was the main predictor of maximum walking distance.CONCLUSIONSMyofiber morphometrics of PAD gastrocnemius differ significantly from those of control muscle and predict calf muscle strength and walking distances of the PAD patients. Morphometric parameters of gastrocnemius myofibers may serve as objective criteria for diagnosis, staging, and treatment of PAD. |
| Author | Uchida, Koji Casale, George P. Pipinos, Iraklis I. Myers, Sara A. Ha, Duy M. Cluff, Kim Haynatzki, Gleb Koutakis, Panagiotis Miserlis, Dimitrios Papoutsi, Evlampia McComb, Rodney D. Johanning, Jason M. |
| AuthorAffiliation | e Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska g Department of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska d Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska c Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, Nebraska a Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska b Nebraska Biomechanics Core Facility, University of Nebraska Omaha, Omaha, Nebraska f Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan |
| AuthorAffiliation_xml | – name: a Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska – name: f Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan – name: d Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska – name: g Department of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska – name: e Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska – name: c Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, Nebraska – name: b Nebraska Biomechanics Core Facility, University of Nebraska Omaha, Omaha, Nebraska |
| Author_xml | – sequence: 1 givenname: Panagiotis surname: Koutakis fullname: Koutakis, Panagiotis organization: Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska – sequence: 2 givenname: Sara A. surname: Myers fullname: Myers, Sara A. organization: Nebraska Biomechanics Core Facility, University of Nebraska Omaha, Omaha, Nebraska – sequence: 3 givenname: Kim surname: Cluff fullname: Cluff, Kim organization: Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, Kansas – sequence: 4 givenname: Duy M. surname: Ha fullname: Ha, Duy M. organization: Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska – sequence: 5 givenname: Gleb surname: Haynatzki fullname: Haynatzki, Gleb organization: Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska – sequence: 6 givenname: Rodney D. surname: McComb fullname: McComb, Rodney D. organization: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska – sequence: 7 givenname: Koji surname: Uchida fullname: Uchida, Koji organization: Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan – sequence: 8 givenname: Dimitrios surname: Miserlis fullname: Miserlis, Dimitrios organization: Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska – sequence: 9 givenname: Evlampia surname: Papoutsi fullname: Papoutsi, Evlampia organization: Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska – sequence: 10 givenname: Jason M. surname: Johanning fullname: Johanning, Jason M. organization: Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska – sequence: 11 givenname: George P. surname: Casale fullname: Casale, George P. email: gpcasale@unmc.edu organization: Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska – sequence: 12 givenname: Iraklis I. surname: Pipinos fullname: Pipinos, Iraklis I. email: ipipinos@unmc.edu organization: Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25791828$$D View this record in MEDLINE/PubMed |
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| Keywords | Walking distance Claudication Myofiber morphology |
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| Snippet | Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit... Abstract Background Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic... BACKGROUNDPeripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that... |
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| SubjectTerms | Aged Claudication Extremities - physiopathology Female Humans Intermittent Claudication - pathology Intermittent Claudication - physiopathology Male Middle Aged Muscle Fibers, Skeletal - pathology Muscle Strength Myofiber morphology Surgery Walking distance |
| Title | Abnormal myofiber morphology and limb dysfunction in claudication |
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