Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 Has a Therapeutic Potential and Sensitizes Cisplatin in Nasopharyngeal Carcinoma

• Published in: PloS one Vol. 8; no. 3; p. e59879
• Main Authors: Yang, Fen, Qian, Xiao-Jun, Qin, Wei, Deng, Rong, Wu, Xiao-Qi, Qin, Juan, Feng, Gong-Kan, Zhu, Xiao-Feng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.03.2013; Public Library of Science (PLoS)
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animal models; Animals; Anticancer properties; Antitumor activity; Apoptosis; Apoptosis - drug effects; Bax protein; Bcl-2 protein; Biology; Blotting, Western; Brain cancer; Breast cancer; Butadienes - pharmacology; Butadienes - therapeutic use; Cancer; Cancer therapies; Carcinoma; Cell cycle; Cell Cycle - drug effects; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Cisplatin - therapeutic use; Clinical trials; Cyclin-dependent kinase 4; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Exposure; Female; Health aspects; Humans; Imidazoles - pharmacology; Imidazoles - therapeutic use; Immunoglobulins; Inhibition; Inhibitors; Iodides; Kinases; Laboratories; Leukemia; Male; Mammals; Mathematics; Mcl-1 protein; Medical research; Medicine; Metastasis; Mice; Mice, Inbred BALB C; Mutation; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - enzymology; Nasopharyngeal Neoplasms - metabolism; Nitriles - pharmacology; Nitriles - therapeutic use; Oncology; Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Phosphotransferases; Propidium iodide; Quinolines - pharmacology; Quinolines - therapeutic use; Radiation therapy; Rapamycin; Signal transduction; Signal Transduction - drug effects; Solid tumors; Throat cancer; TOR protein; TOR Serine-Threonine Kinases - antagonists & inhibitors; Toxicity; Tumor cells; Tumors; Western blotting; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation; China

Phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells and thus has been considered as a promising drug target. To ascertain a therapeutical approach of nasopharyngeal carcinoma (NPC), we hypothesized NVP-BEZ...