Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells from Subjects with Pulmonary Arterial Hypertension Is Activated through JNK and p38 MAPK - Wilson, Jamie L.; Yu, Jun; Taylor, Linda; Polgar, Peter (PloS one, 2015)
Keywords: Actin; Activation; Becaplermin; Biochemistry; Cell cycle; Cell Cycle - physiology; Cell growth; Cell proliferation; Cell Proliferation - physiology; Cells, Cultured; Etiology; Familial Primary Pulmonary Hypertension - metabolism; Familial Primary Pulmonary Hypertension - pathology; Fibroblast growth factor 2; Fibroblast Growth Factor 2 - metabolism; Fibroblast growth factors; Genotype & phenotype; Growth; Growth factors; Humans; Hyperplasia; Hypertension; Hypertension, Pulmonary - metabolism; Hypertension, Pulmonary - pathology; Hypoxia; JNK protein; Kinases; MAP kinase; MAP Kinase Kinase 4 - metabolism; Medicine; Muscle proteins; Muscles; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphotransferases; Platelet-derived growth factor; Platelet-derived growth factor BB; Protein-tyrosine kinase receptors; Proteins; Proto-Oncogene Proteins c-sis - metabolism; Pulmonary arteries; Pulmonary artery; Pulmonary Artery - metabolism; Pulmonary Artery - pathology; Pulmonary hypertension; Rodents; Signal transduction; Signal Transduction - physiology; Smooth muscle; TOR protein; TOR Serine-Threonine Kinases - metabolism; Transcription factors; Tyrosine; Veins & arteries