Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function

• Published in: PloS one Vol. 11; no. 2; p. e0149792
• Main Authors: Fonseca, Maria I, Chu, Shuhui, Pierce, Aimee L, Brubaker, William D, Hauhart, Richard E, Mastroeni, Diego, Clarke, Elizabeth V, Rogers, Joseph, Atkinson, John P, Tenner, Andrea J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.02.2016; Public Library of Science (PLoS)
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Alzheimers disease; Analysis; Antibodies; Astrocytes; Astrocytes - metabolism; Binding; Biochemistry; Biology and Life Sciences; Blood; Blood cells; Blood vessels; Brain; Brain - pathology; Brain research; Cell receptors; Complement activation; Complement C1q - metabolism; Complement C3b - metabolism; Complement component C1q; Complement component C3b; Development and progression; Diagnosis; Enzyme-linked immunosorbent assay; Epitopes; Erythrocytes; Erythrocytes - metabolism; Female; Gene Expression Regulation; Genetic aspects; Genetic Predisposition to Disease - genetics; Genomes; Genotypes; Humans; Immune system; Male; Medicine; Medicine and Health Sciences; Molecular biology; Neurodegenerative diseases; Neurological disorders; Neurosciences; Parenchyma; Physical Sciences; Physiological aspects; Plasma levels; Polymorphism, Single Nucleotide; Protein Transport; Proteins; Receptors, Complement 3b - blood; Receptors, Complement 3b - genetics; Receptors, Complement 3b - metabolism; Red blood cells; Research and Analysis Methods; Rheumatology; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Staining; Statistical analysis; Statistical methods; United States; Oregon; California; United States > US; Arizona; Missouri

Chronic activation of the complement system and induced inflammation are associated with neuropathology in Alzheimer's disease (AD). Recent large genome wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in the C3b/C4b receptor (CR1 or CD35) that are associat...