Piscine Orthoreovirus from Western North America Is Transmissible to Atlantic Salmon and Sockeye Salmon but Fails to Cause Heart and Skeletal Muscle Inflammation

• Published in: PloS one Vol. 11; no. 1; p. e0146229
• Main Authors: Garver, Kyle A., Johnson, Stewart C., Polinski, Mark P., Bradshaw, Julia C., Marty, Gary D., Snyman, Heindrich N., Morrison, Diane B., Richard, Jon
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.01.2016; Public Library of Science (PLoS)
• Subjects: Amino Acid Sequence; Analysis; Anemia; Animals; Antiviral agents; Aquaculture; Blood; Cardiomyopathies - virology; Cardiomyopathy; Causation; Clupea harengus; Cohabitation; Comparative analysis; Disease; Endemic Diseases; Epidemics; Etiology; Farming; Fish; Fish diseases; Fish Diseases - epidemiology; Fish Diseases - transmission; Fish Diseases - virology; Fisheries; Health aspects; Heart; Host-Pathogen Interactions; Infectivity; Inflammation; Kidneys; Laboratories; Lesions; Mallotus villosus; Molecular Sequence Data; Muscle, Skeletal - pathology; Muscle, Skeletal - virology; Muscles; Musculoskeletal system; Myositis - virology; North America - epidemiology; Oncorhynchus nerka; Orthoreovirus - classification; Orthoreovirus - genetics; Orthoreovirus - physiology; Peripheral blood; Phylogeny; Physiological aspects; Prevalence; Reoviridae Infections - epidemiology; Reoviridae Infections - transmission; Reoviridae Infections - virology; Ribonucleic acid; RNA; RNA, Viral - blood; RNA, Viral - genetics; RNA, Viral - metabolism; Salmo salar; Salmo salar - blood; Salmo salar - virology; Salmon; Salmonidae; Sequence Homology, Amino Acid; Skeletal muscle; Studies; Time Factors; Transcription; Virology; Viruses; North America
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0146229

Heart and skeletal muscle inflammation (HSMI) is a significant and often fatal disease of cultured Atlantic salmon in Norway. The consistent presence of Piscine orthoreovirus (PRV) in HSMI diseased fish along with the correlation of viral load and antigen with development of lesions has supported th...