Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation

• Published in: PloS one Vol. 10; no. 8; p. e0136769
• Main Authors: Filograna, Roberta, Civiero, Laura, Ferrari, Vanni, Codolo, Gaia, Greggio, Elisa, Bubacco, Luigi, Beltramini, Mariano, Bisaglia, Marco
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.08.2015; Public Library of Science (PLoS)
• Subjects: 12-O-Tetradecanoylphorbol-13-acetate; Acetic acid; Acids; Biology; Biophysics; Biotechnology; Cancer; Catecholamine; Catecholamines; Catecholamines - biosynthesis; Cell culture; Cell differentiation; Cell Differentiation - drug effects; Cell division; Cell growth; Cell Line, Tumor; Cell lines; Cell proliferation; Comparative analysis; Cytology; Development and progression; Differentiation; Dopamine; Gene expression; Genetic aspects; Genotype & phenotype; Humans; Kinases; Morphology; Nervous system; Neuroblastoma; Neuroblastoma - metabolism; Neuroblastoma - pathology; Neurons; Neurotoxicity; Neurotransmitters; Noradrenaline; Norepinephrine; Phenotypes; Physiological aspects; Physiology; Proteins; Retinoic acid; Staurosporine; Staurosporine - pharmacology; Tetradecanoylphorbol Acetate - pharmacology; Toxicity; Tretinoin - pharmacology; Italy

Human cell lines are often used to investigate cellular pathways relevant for physiological or pathological processes or to evaluate cell toxicity or protection induced by different compounds, including potential drugs. In this study, we analyzed and compared the differentiating activities of three...