Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: Dose-efficacy studies upon oral administration

• Published in: PloS one Vol. 13; no. 10; p. e0206416
• Main Authors: Tani, Hideki, Komeno, Takashi, Fukuma, Aiko, Fukushi, Shuetsu, Taniguchi, Satoshi, Shimojima, Masayuki, Uda, Akihiko, Morikawa, Shigeru, Nakajima, Nozomi, Furuta, Yousuke, Saijo, Masayuki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.10.2018; Public Library of Science (PLoS)
• Subjects: Administration, Oral; Amides - administration & dosage; Amides - pharmacology; Amides - therapeutic use; Analysis; Animals; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antiviral agents; Biology and Life Sciences; Body weight; Cercopithecus aethiops; Disease Models, Animal; Dose-response relationship (Biochemistry); Dose-Response Relationship, Drug; Drug dosages; Drug therapy; Ebola virus; Fatalities; Fever; Hemorrhage; Hemorrhagic fever; Infections; Infectious diseases; Influenza; Interferon; Laboratories; Medicine and Health Sciences; Mice; Mortality; Neutralizing; Oral administration; People and Places; Peritoneum; Phlebotomus Fever - drug therapy; Phlebovirus - drug effects; Phlebovirus - immunology; Phlebovirus - physiology; Pyrazines - administration & dosage; Pyrazines - pharmacology; Pyrazines - therapeutic use; Research and Analysis Methods; RNA polymerase; Rodents; Thrombocytopenia; Tissue culture; Vero Cells; Virology; Viruses; Japan

Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), is a viral hemorrhagic fever with a high case fatality rate. Favipiravir was reported to be effective in the treatment of SFTSV infection in vivo in type I interferon receptor knockout (IFNAR-/-) mice at treatment dosa...