Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: Dose-efficacy studies upon oral administration - Tani, Hideki; Komeno, Takashi; Fukuma, Aiko; Fukushi, Shuetsu; Taniguchi, Satoshi; Shimojima, Masayuki; Uda, Akihiko; Morikawa, Shigeru; Nakajima, Nozomi; Furuta, Yousuke; Saijo, Masayuki (PloS one, 2018)
Keywords: Administration, Oral; Amides - administration & dosage; Amides - pharmacology; Amides - therapeutic use; Analysis; Animals; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antiviral agents; Biology and Life Sciences; Body weight; Cercopithecus aethiops; Disease Models, Animal; Dose-response relationship (Biochemistry); Dose-Response Relationship, Drug; Drug dosages; Drug therapy; Ebola virus; Fatalities; Fever; Hemorrhage; Hemorrhagic fever; Infections; Infectious diseases; Influenza; Interferon; Laboratories; Medicine and Health Sciences; Mice; Mortality; Neutralizing; Oral administration; People and Places; Peritoneum; Phlebotomus Fever - drug therapy; Phlebovirus - drug effects; Phlebovirus - immunology; Phlebovirus - physiology; Pyrazines - administration & dosage; Pyrazines - pharmacology; Pyrazines - therapeutic use; Research and Analysis Methods; RNA polymerase; Rodents; Thrombocytopenia; Tissue culture; Vero Cells; Virology; Viruses; Japan