Neuroenhancement and neuroprotection by oral solution citicoline in non-arteritic ischemic optic neuropathy as a model of neurodegeneration: A randomized pilot study

• Published in: PloS one Vol. 14; no. 7; p. e0220435
• Main Authors: Parisi, Vincenzo, Barbano, Lucilla, Di Renzo, Antonio, Coppola, Gianluca, Ziccardi, Lucia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.07.2019; Public Library of Science (PLoS)
• Subjects: Acuity; Administration, Oral; Age; Aged; Apoptosis; Biology and Life Sciences; Citicoline; Correlation analysis; Cytidine diphosphate choline; Cytidine Diphosphate Choline - administration & dosage; Cytidine Diphosphate Choline - pharmacology; Degeneration; Disease; Drug Administration Schedule; Drug therapy; Electroretinography; Evoked Potentials, Visual - drug effects; Eye; Eye (anatomy); Female; Ganglion cysts; Glaucoma; Health aspects; Humans; Ischemia; Male; Medicine and Health Sciences; Middle Aged; Nerve conduction; Nerve degeneration; Nervous system; Neurodegeneration; Neuropathy; Neuroprotection; Neuroprotective agents; Optic nerve; Optic nerve diseases; Optic neuropathy; Optic Neuropathy, Ischemic - drug therapy; Optic Neuropathy, Ischemic - physiopathology; Optical fibers; Optics; Oral drugs; Pathways; Pharmaceutical Solutions; Pilot Projects; Preservation; Research and Analysis Methods; Retina; Retinal ganglion cells; Social Sciences; Stroke; Studies; Testing; Thickness; Tomography; Treatment Outcome; Variance analysis; Vision Tests; Visual acuity; Visual evoked potentials; Visual field; Visual fields; Visual pathways; Visual perception; Italy

To evaluate whether treatment with Citicoline in oral solution (OS-Citicoline) would increase visual function, retinal ganglion cells (RGCs) function, and neural conduction along visual pathways (neuroenhancement), and/or induce preservation of RGCs fibers' loss (neuroprotection) in non-arterit...