Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1

• Published in: PloS one Vol. 9; no. 10; p. e109655
• Main Authors: Kim, Ye Seul, Kim, Seong-Hoon, Shin, Joon, Harikishore, Amaravadhi, Lim, Jong-Kwan, Jung, Youngseob, Lyu, Ha-Na, Baek, Nam-In, Choi, Kwan Yong, Yoon, Ho Sup, Kim, Kyong-Tai
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.10.2014; Public Library of Science (PLoS)
• Subjects: Anticancer properties; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis; B cells; Biology and Life Sciences; Biotechnology; Cancer; Cancer therapies; Catalysis; Catalytic Domain - drug effects; Cell cycle; Cell division; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cyclic AMP response element-binding protein; Deoxyribonucleic acid; DNA; DNA damage; DNA-Binding Proteins - metabolism; Drug delivery; Drugs; Flavonoids; Health aspects; Histone H3; Histones - metabolism; Humans; Inhibitors; Intracellular Signaling Peptides and Proteins - antagonists & inhibitors; Intracellular Signaling Peptides and Proteins - chemistry; Kinases; Life sciences; Luteolin - chemistry; Luteolin - pharmacology; Metastasis; Nuclear Proteins - metabolism; Phase transitions; Phosphatase; Phosphorylation; Phosphorylation - drug effects; Phosphotransferases; Polyphenols; Protein binding; Protein kinase; Protein-Serine-Threonine Kinases - antagonists & inhibitors; Protein-Serine-Threonine Kinases - chemistry; Proteins; Regulators; Side effects; Substrates; Therapy; Vaccinia; South Korea; Singapore

Uncontrolled proliferation, a major feature of cancer cells, is often triggered by the malfunction of cell cycle regulators such as protein kinases. Recently, cell cycle-related protein kinases have become attractive targets for anti-cancer therapy, because they play fundamental roles in cellular pr...