The Systemic Inflammatory Response to Clostridium difficile Infection

• Published in: PloS one Vol. 9; no. 3; p. e92578
• Main Authors: Rao, Krishna, Erb-Downward, John R., Walk, Seth T., Micic, Dejan, Falkowski, Nicole, Santhosh, Kavitha, Mogle, Jill A., Ring, Cathrin, Young, Vincent B., Huffnagle, Gary B., Aronoff, David M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.03.2014; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies; Biology and Life Sciences; Biomarkers; Case-Control Studies; Chemokines; Clostridioides difficile - immunology; Clostridium difficile; Clostridium Infections - blood; Clostridium Infections - immunology; Colorectal surgery; Critical care; Cytokines; Diarrhea; Diarrhea - blood; Diarrhea - immunology; Diarrhea - microbiology; Eotaxin; Epidermal growth factor; Female; Fibroblast growth factor 2; Gastroenteritis - blood; Gastroenteritis - immunology; Gastroenteritis - microbiology; Health aspects; Hepatocyte growth factor; Hospital patients; Humans; Immunology; Infection; Infections; Infectious diseases; Inflammation; Inflammation Mediators - blood; Inflammatory response; Intercellular Signaling Peptides and Proteins - blood; Interleukin 6; Interleukin 8; Internal medicine; Male; Medicine; Medicine and Health Sciences; Middle Aged; Multivariate analysis; Nosocomial infections; Ostomy; Principal components analysis; Proteins; Regression analysis; Rodents; Studies; Variance analysis; Young Adult; Montana; Ann Arbor Michigan; United States > US; Michigan

The systemic inflammatory response to Clostridium difficile infection (CDI) is incompletely defined, particularly for patients with severe disease. Analysis of 315 blood samples from 78 inpatients with CDI (cases), 100 inpatients with diarrhea without CDI (inpatient controls), and 137 asymptomatic o...