Mycobacterium tuberculosis Genotypes Determined by Spoligotyping to Be Circulating in Colombia between 1999 and 2012 and Their Possible Associations with Transmission and Susceptibility to First-Line Drugs

• Published in: PloS one Vol. 10; no. 6; p. e0124308
• Main Authors: Puerto, Gloria, Erazo, Lina, Wintaco, Maira, Castro, Claudia, Ribón, Wellman, Guerrero, Martha Inírida
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.06.2015; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antitubercular Agents - pharmacology; Antitubercular Agents - therapeutic use; Bacterial Typing Techniques - methods; Child; Child, Preschool; Clustering; Colombia - epidemiology; Disease control; Disease transmission; Drug resistance; Drug Resistance, Bacterial; Drugs; Epidemiology; Female; Genetic diversity; Genotype; Genotypes; Health surveillance; Humans; Laboratories; Male; Medical screening; Methods; Middle Aged; Molecular Typing - methods; Multidrug resistance; Mycobacterium tuberculosis; Mycobacterium tuberculosis - classification; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - genetics; Phylogeography; Population structure; Public health; Spoligotyping; Tuberculosis; Tuberculosis - epidemiology; Tuberculosis - prevention & control; Young Adult; Colombia; Beijing China; United States > US; China; Ethiopia

Tuberculosis (TB) remains a primary public health problem worldwide. The number of multidrug-resistant tuberculosis (MDR TB) cases has increased in recent years in Colombia. Knowledge of M. tuberculosis genotypes defined by spoligotyping can help determine the circulation of genotypes that must be c...