Analysis of Immune Response Markers in Jorge Lobo's Disease Lesions Suggests the Occurrence of Mixed T Helper Responses with the Dominance of Regulatory T Cell Activity

• Published in: PloS one Vol. 10; no. 12; p. e0145814
• Main Authors: Azevedo, Michelle de C S, Rosa, Patricia S, Soares, Cleverson T, Fachin, Luciana R V, Baptista, Ida Maria F D, Woods, William J, Garlet, Gustavo P, Trombone, Ana Paula F, Belone, Andrea de F F
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.12.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Belone; Biological markers; Blastomycosis; Candida albicans; Cells, Cultured; Chronic infection; CTLA-4 protein; Cytokines; Development and progression; Disease; Dominance; Etiology; Female; Foxp3 protein; Fungi; GATA-3 protein; Health aspects; Helper cells; Humans; Immune response; Immune system; Immunity, Cellular - immunology; Immunoenzyme Techniques; Immunology; Infections; Interferon; Interleukin 10; Interleukin 13; Interleukin 22; Interleukin 4; Interleukin 5; Kinases; Lesions; Lobomycosis - diagnosis; Lobomycosis - genetics; Lobomycosis - immunology; Lymphocytes; Lymphocytes T; Male; Markers; Middle Aged; mRNA; Pathogenesis; Patients; Real time; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Skin; Skin diseases; Surgery; T cells; T-Lymphocytes, Helper-Inducer - immunology; T-Lymphocytes, Regulatory - immunology; Tissues; Transforming growth factor-b1; Young Adult; γ-Interferon; Brazil

Jorge Lobo's disease (JLD) is a chronic infection that affects the skin and subcutaneous tissues. Its etiologic agent is the fungus Lacazia loboi. Lesions are classified as localized, multifocal, or disseminated, depending on their location. Early diagnosis and the surgical removal of lesions a...