Procedures for Behavioral Experiments in Head-Fixed Mice

• Published in: PloS one Vol. 9; no. 2; p. e88678
• Main Authors: Guo, Zengcai V., Hires, S. Andrew, Li, Nuo, O'Connor, Daniel H., Komiyama, Takaki, Ophir, Eran, Huber, Daniel, Bonardi, Claudia, Morandell, Karin, Gutnisky, Diego, Peron, Simon, Xu, Ning-long, Cox, James, Svoboda, Karel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.02.2014; Public Library of Science (PLoS)
• Subjects: Access control; Animal behavior; Animal experimentation; Animals; Behavior; Behavior, Animal - physiology; Biology; Body Weight; Brain research; Circuits; Discrimination (Psychology); Ethology - methods; Experiments; Exploration; Fixation; Head; Head movement; Health aspects; Health risks; Human behavior; Humans; Laboratories; Learning; Male; Medical research; Mental task performance; Mice; Mice, Inbred C57BL; Monkeys & apes; Neural circuitry; Neural networks; Neurobiology; Neurons; Neurophysiology; Neurosciences; Operant conditioning; Physiology; Primates; Random access; Reward; Rodents; Sensory stimuli; Stimuli; Stimulus control; Sucrose; Task Performance and Analysis; Touch; Training; Vibrissae; Water; Water Deprivation

The mouse is an increasingly prominent model for the analysis of mammalian neuronal circuits. Neural circuits ultimately have to be probed during behaviors that engage the circuits. Linking circuit dynamics to behavior requires precise control of sensory stimuli and measurement of body movements. He...