Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer

• Published in: PloS one Vol. 12; no. 5; p. e0177694
• Main Authors: Liu, Zhaoyun, He, Kewen, Ma, Qinghua, Yu, Qian, Liu, Chenyu, Ndege, Isabella, Wang, Xinzhao, Yu, Zhiyong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.05.2017; Public Library of Science (PLoS)
• Subjects: Adenine - administration & dosage; Adenine - analogs & derivatives; Adenine - pharmacology; Adenocarcinoma; Animals; Antibiotics; Antibodies; Antitumor activity; Apoptosis; Atmosphere; ATP; Autophagy; Autophagy - drug effects; Bcl protein; Bcl-2 protein; Betulinic acid; Binding sites; Biology; Biology and Life Sciences; Breast cancer; Cancer therapies; Carbon dioxide; Cardiovascular system; Caspase; Caspase 3 - metabolism; Cell culture; Cell cycle; Cell Cycle Checkpoints - drug effects; Cell death; Cell growth; Cell Line, Tumor; Cell Survival - drug effects; Chemotherapy; Colorectal carcinoma; Cytochrome; Cytochromes c - metabolism; Cytotoxicity; Degradation; Deoxyribonucleic acid; DNA; DNA repair; Dosage and administration; Drug resistance; Drug Synergism; Drugs; Epidermal growth factor; Esters; Estrogens; Fatty acids; Female; Fruits; Gefitinib; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genetics; Glucose; Health aspects; Health risks; Humans; Immunoglobulin G; In Vitro Techniques; Inhibition; Inhibitor drugs; Inhibitors; Kinases; Leukemia; Life sciences; Liver; Lung cancer; Macrolides - administration & dosage; Macrolides - pharmacology; Macromolecules; Medical prognosis; Medicine; Medicine and Health Sciences; Membrane proteins; Metastases; Mice; Mice, Nude; Mitochondria; Mitochondria - drug effects; Myeloid leukemia; Oncology; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - pharmacology; Proteins; Proto-Oncogene Proteins c-bcl-2 - metabolism; Quinazolines - administration & dosage; Quinazolines - pharmacology; Research and Analysis Methods; Targeted cancer therapy; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - metabolism; Xenograft Model Antitumor Assays; China

Epidermal growth factor receptor (EGFR) is over-expressed in about 50% of Triple negative breast cancers (TNBCs), but EGFR inhibitors have not been effective in treating TNBC patients. Increasing evidence supports that autophagy was related to drug resistance at present. However, the role and the me...