Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer - Liu, Zhaoyun; He, Kewen; Ma, Qinghua; Yu, Qian; Liu, Chenyu; Ndege, Isabella; Wang, Xinzhao; Yu, Zhiyong (PloS one, 2017)
Keywords: Adenine - administration & dosage; Adenine - analogs & derivatives; Adenine - pharmacology; Adenocarcinoma; Animals; Antibiotics; Antibodies; Antitumor activity; Apoptosis; Atmosphere; ATP; Autophagy; Autophagy - drug effects; Bcl protein; Bcl-2 protein; Betulinic acid; Binding sites; Biology; Biology and Life Sciences; Breast cancer; Cancer therapies; Carbon dioxide; Cardiovascular system; Caspase; Caspase 3 - metabolism; Cell culture; Cell cycle; Cell Cycle Checkpoints - drug effects; Cell death; Cell growth; Cell Line, Tumor; Cell Survival - drug effects; Chemotherapy; Colorectal carcinoma; Cytochrome; Cytochromes c - metabolism; Cytotoxicity; Degradation; Deoxyribonucleic acid; DNA; DNA repair; Dosage and administration; Drug resistance; Drug Synergism; Drugs; Epidermal growth factor; Esters; Estrogens; Fatty acids; Female; Fruits; Gefitinib; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genetics; Glucose; Health aspects; Health risks; Humans; Immunoglobulin G; In Vitro Techniques; Inhibition; Inhibitor drugs; Inhibitors; Kinases; Leukemia; Life sciences; Liver; Lung cancer; Macrolides - administration & dosage; Macrolides - pharmacology; Macromolecules; Medical prognosis; Medicine; Medicine and Health Sciences; Membrane proteins; Metastases; Mice; Mice, Nude; Mitochondria; Mitochondria - drug effects; Myeloid leukemia; Oncology; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - pharmacology; Proteins; Proto-Oncogene Proteins c-bcl-2 - metabolism; Quinazolines - administration & dosage; Quinazolines - pharmacology; Research and Analysis Methods; Targeted cancer therapy; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - metabolism; Xenograft Model Antitumor Assays; China