Serum asunaprevir concentrations showing correlation with the extent of liver fibrosis as a factor inducing liver injuries in patients with genotype-1b hepatitis C virus receiving daclatasvir plus asunaprevir therapy - Uchida, Yoshihito; Naiki, Kayoko; Kouyama, Jun-ichi; Sugawara, Kayoko; Nakao, Masamitsu; Motoya, Daisuke; Inao, Mie; Nakayama, Nobuaki; Imai, Yukinori; Tomiya, Tomoaki; Mochida, Satoshi (PloS one, 2018)
Keywords: Adult; Aged; Analysis; Antigens, Neoplasm - blood; Antiviral agents; Antiviral Agents - adverse effects; Antiviral Agents - blood; Antiviral Agents - therapeutic use; Antiviral drugs; Biology and Life Sciences; Biomarkers - blood; Carbamates; Care and treatment; Complications and side effects; Confidence intervals; Consent; Correlation; Drug dosages; Drug Therapy, Combination - adverse effects; Female; Fibrosis; Gastroenterology; Genetic aspects; Genotype & phenotype; Genotypes; Glycosylation; Hemodialysis; Hepacivirus - genetics; Hepatitis; Hepatitis C; Hepatitis C virus; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - virology; Hepatology; Humans; Imidazoles - adverse effects; Imidazoles - blood; Imidazoles - therapeutic use; Injuries; Interferon; Isoquinolines - adverse effects; Isoquinolines - blood; Isoquinolines - therapeutic use; Liver; Liver cancer; Liver cirrhosis; Liver Cirrhosis - blood; Liver Cirrhosis - etiology; Male; Medicine; Medicine and Health Sciences; Membrane Glycoproteins - blood; Middle Aged; Patients; Platelets; Protease Inhibitors - adverse effects; Protease Inhibitors - blood; Protease Inhibitors - therapeutic use; Protein binding; Protein Isoforms - blood; Proteins; Pyrrolidines; Regression analysis; Research and Analysis Methods; Retrospective Studies; Risk factors; Serum albumin; Statistical analysis; Sulfonamides - adverse effects; Sulfonamides - blood; Sulfonamides - therapeutic use; Therapy; Transaminase; Valine - analogs & derivatives; Viruses; Young Adult; Japan