Part time patching treatment outcomes in children with amblyopia with and without fusion maldevelopment nystagmus: An eye movement study
We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia. We recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. S...
Saved in:
| Published in | PloS one Vol. 15; no. 8; p. e0237346 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
13.08.2020
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia.
We recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. Subjects were classified based on FEM waveforms (those without nystagmus = 21, those with nystagmus without fusion maldevelopment nystagmus (FMN) = 21, and those with FMN = 11) and based on clinical type of amblyopia (anisometropic = 18, strabismic = 6, and mixed = 29). The treatment outcomes such as duration of treatment of receiving part-time patching therapy, visual acuity and stereo-acuity deficits at the end of treatment were determined. Bivariate contour ellipse area (BCEA), fast (fixational saccade/quick phases), and slow (inter-saccadic drifts/slow phases) FEMs of the fellow and amblyopic eye were analyzed.
Anisometropic group had less residual amblyopia (0.23±0.19logMAR acuity) compared to strabismic/mixed (0.36±0.26) groups (p = 0.007). Treatment duration in patients without nystagmus was lower (12.6±9.5months) compared to nystagmus without FMN (25.6±23.2) and FMN (29.5±20.4) groups (p = 0.006). Patients without nystagmus had better stereopsis at the end of treatment (2.3±0.84logarcsecs) compared to nystagmus without FMN (2.6±0.84) group (p = 0.003). The majority of patients with FMN (8/11) had absent stereopsis. BCEA of the amblyopic eye was higher in patients with greater residual visual acuity deficits in patients without nystagmus. No such association was seen in Nystagmus no FMN and FMN groups. Increased amplitude of fast FEMs, increased eye position variance and eye velocity of slow FEMs were seen in patients who had received longer duration of part time patching therapy and in those with greater residual amblyopia, and poor stereopsis at the end of treatment.
Assessment of FEM waveforms and fast and slow FEM characteristics are important measures while describing fixation instability in amblyopia. Several FEM abnormalities were associated with stereo-acuity and visual acuity deficits and treatment duration in patients with amblyopia treated with part time patching therapy. |
|---|---|
| AbstractList | We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia.
We recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. Subjects were classified based on FEM waveforms (those without nystagmus = 21, those with nystagmus without fusion maldevelopment nystagmus (FMN) = 21, and those with FMN = 11) and based on clinical type of amblyopia (anisometropic = 18, strabismic = 6, and mixed = 29). The treatment outcomes such as duration of treatment of receiving part-time patching therapy, visual acuity and stereo-acuity deficits at the end of treatment were determined. Bivariate contour ellipse area (BCEA), fast (fixational saccade/quick phases), and slow (inter-saccadic drifts/slow phases) FEMs of the fellow and amblyopic eye were analyzed.
Anisometropic group had less residual amblyopia (0.23±0.19logMAR acuity) compared to strabismic/mixed (0.36±0.26) groups (p = 0.007). Treatment duration in patients without nystagmus was lower (12.6±9.5months) compared to nystagmus without FMN (25.6±23.2) and FMN (29.5±20.4) groups (p = 0.006). Patients without nystagmus had better stereopsis at the end of treatment (2.3±0.84logarcsecs) compared to nystagmus without FMN (2.6±0.84) group (p = 0.003). The majority of patients with FMN (8/11) had absent stereopsis. BCEA of the amblyopic eye was higher in patients with greater residual visual acuity deficits in patients without nystagmus. No such association was seen in Nystagmus no FMN and FMN groups. Increased amplitude of fast FEMs, increased eye position variance and eye velocity of slow FEMs were seen in patients who had received longer duration of part time patching therapy and in those with greater residual amblyopia, and poor stereopsis at the end of treatment.
Assessment of FEM waveforms and fast and slow FEM characteristics are important measures while describing fixation instability in amblyopia. Several FEM abnormalities were associated with stereo-acuity and visual acuity deficits and treatment duration in patients with amblyopia treated with part time patching therapy. Purpose We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia. Methods We recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. Subjects were classified based on FEM waveforms (those without nystagmus = 21, those with nystagmus without fusion maldevelopment nystagmus (FMN) = 21, and those with FMN = 11) and based on clinical type of amblyopia (anisometropic = 18, strabismic = 6, and mixed = 29). The treatment outcomes such as duration of treatment of receiving part-time patching therapy, visual acuity and stereo-acuity deficits at the end of treatment were determined. Bivariate contour ellipse area (BCEA), fast (fixational saccade/quick phases), and slow (inter-saccadic drifts/slow phases) FEMs of the fellow and amblyopic eye were analyzed. Results Anisometropic group had less residual amblyopia (0.23±0.19logMAR acuity) compared to strabismic/mixed (0.36±0.26) groups (p = 0.007). Treatment duration in patients without nystagmus was lower (12.6±9.5months) compared to nystagmus without FMN (25.6±23.2) and FMN (29.5±20.4) groups (p = 0.006). Patients without nystagmus had better stereopsis at the end of treatment (2.3±0.84logarcsecs) compared to nystagmus without FMN (2.6±0.84) group (p = 0.003). The majority of patients with FMN (8/11) had absent stereopsis. BCEA of the amblyopic eye was higher in patients with greater residual visual acuity deficits in patients without nystagmus. No such association was seen in Nystagmus no FMN and FMN groups. Increased amplitude of fast FEMs, increased eye position variance and eye velocity of slow FEMs were seen in patients who had received longer duration of part time patching therapy and in those with greater residual amblyopia, and poor stereopsis at the end of treatment. Conclusions Assessment of FEM waveforms and fast and slow FEM characteristics are important measures while describing fixation instability in amblyopia. Several FEM abnormalities were associated with stereo-acuity and visual acuity deficits and treatment duration in patients with amblyopia treated with part time patching therapy. Purpose We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia. Methods We recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. Subjects were classified based on FEM waveforms (those without nystagmus = 21, those with nystagmus without fusion maldevelopment nystagmus (FMN) = 21, and those with FMN = 11) and based on clinical type of amblyopia (anisometropic = 18, strabismic = 6, and mixed = 29). The treatment outcomes such as duration of treatment of receiving part-time patching therapy, visual acuity and stereo-acuity deficits at the end of treatment were determined. Bivariate contour ellipse area (BCEA), fast (fixational saccade/quick phases), and slow (inter-saccadic drifts/slow phases) FEMs of the fellow and amblyopic eye were analyzed. Results Anisometropic group had less residual amblyopia (0.23±0.19logMAR acuity) compared to strabismic/mixed (0.36±0.26) groups (p = 0.007). Treatment duration in patients without nystagmus was lower (12.6±9.5months) compared to nystagmus without FMN (25.6±23.2) and FMN (29.5±20.4) groups (p = 0.006). Patients without nystagmus had better stereopsis at the end of treatment (2.3±0.84logarcsecs) compared to nystagmus without FMN (2.6±0.84) group (p = 0.003). The majority of patients with FMN (8/11) had absent stereopsis. BCEA of the amblyopic eye was higher in patients with greater residual visual acuity deficits in patients without nystagmus. No such association was seen in Nystagmus no FMN and FMN groups. Increased amplitude of fast FEMs, increased eye position variance and eye velocity of slow FEMs were seen in patients who had received longer duration of part time patching therapy and in those with greater residual amblyopia, and poor stereopsis at the end of treatment. Conclusions Assessment of FEM waveforms and fast and slow FEM characteristics are important measures while describing fixation instability in amblyopia. Several FEM abnormalities were associated with stereo-acuity and visual acuity deficits and treatment duration in patients with amblyopia treated with part time patching therapy. We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia. We recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. Subjects were classified based on FEM waveforms (those without nystagmus = 21, those with nystagmus without fusion maldevelopment nystagmus (FMN) = 21, and those with FMN = 11) and based on clinical type of amblyopia (anisometropic = 18, strabismic = 6, and mixed = 29). The treatment outcomes such as duration of treatment of receiving part-time patching therapy, visual acuity and stereo-acuity deficits at the end of treatment were determined. Bivariate contour ellipse area (BCEA), fast (fixational saccade/quick phases), and slow (inter-saccadic drifts/slow phases) FEMs of the fellow and amblyopic eye were analyzed. Anisometropic group had less residual amblyopia (0.23±0.19logMAR acuity) compared to strabismic/mixed (0.36±0.26) groups (p = 0.007). Treatment duration in patients without nystagmus was lower (12.6±9.5months) compared to nystagmus without FMN (25.6±23.2) and FMN (29.5±20.4) groups (p = 0.006). Patients without nystagmus had better stereopsis at the end of treatment (2.3±0.84logarcsecs) compared to nystagmus without FMN (2.6±0.84) group (p = 0.003). The majority of patients with FMN (8/11) had absent stereopsis. BCEA of the amblyopic eye was higher in patients with greater residual visual acuity deficits in patients without nystagmus. No such association was seen in Nystagmus no FMN and FMN groups. Increased amplitude of fast FEMs, increased eye position variance and eye velocity of slow FEMs were seen in patients who had received longer duration of part time patching therapy and in those with greater residual amblyopia, and poor stereopsis at the end of treatment. Assessment of FEM waveforms and fast and slow FEM characteristics are important measures while describing fixation instability in amblyopia. Several FEM abnormalities were associated with stereo-acuity and visual acuity deficits and treatment duration in patients with amblyopia treated with part time patching therapy. We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia.PURPOSEWe investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia.We recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. Subjects were classified based on FEM waveforms (those without nystagmus = 21, those with nystagmus without fusion maldevelopment nystagmus (FMN) = 21, and those with FMN = 11) and based on clinical type of amblyopia (anisometropic = 18, strabismic = 6, and mixed = 29). The treatment outcomes such as duration of treatment of receiving part-time patching therapy, visual acuity and stereo-acuity deficits at the end of treatment were determined. Bivariate contour ellipse area (BCEA), fast (fixational saccade/quick phases), and slow (inter-saccadic drifts/slow phases) FEMs of the fellow and amblyopic eye were analyzed.METHODSWe recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. Subjects were classified based on FEM waveforms (those without nystagmus = 21, those with nystagmus without fusion maldevelopment nystagmus (FMN) = 21, and those with FMN = 11) and based on clinical type of amblyopia (anisometropic = 18, strabismic = 6, and mixed = 29). The treatment outcomes such as duration of treatment of receiving part-time patching therapy, visual acuity and stereo-acuity deficits at the end of treatment were determined. Bivariate contour ellipse area (BCEA), fast (fixational saccade/quick phases), and slow (inter-saccadic drifts/slow phases) FEMs of the fellow and amblyopic eye were analyzed.Anisometropic group had less residual amblyopia (0.23±0.19logMAR acuity) compared to strabismic/mixed (0.36±0.26) groups (p = 0.007). Treatment duration in patients without nystagmus was lower (12.6±9.5months) compared to nystagmus without FMN (25.6±23.2) and FMN (29.5±20.4) groups (p = 0.006). Patients without nystagmus had better stereopsis at the end of treatment (2.3±0.84logarcsecs) compared to nystagmus without FMN (2.6±0.84) group (p = 0.003). The majority of patients with FMN (8/11) had absent stereopsis. BCEA of the amblyopic eye was higher in patients with greater residual visual acuity deficits in patients without nystagmus. No such association was seen in Nystagmus no FMN and FMN groups. Increased amplitude of fast FEMs, increased eye position variance and eye velocity of slow FEMs were seen in patients who had received longer duration of part time patching therapy and in those with greater residual amblyopia, and poor stereopsis at the end of treatment.RESULTSAnisometropic group had less residual amblyopia (0.23±0.19logMAR acuity) compared to strabismic/mixed (0.36±0.26) groups (p = 0.007). Treatment duration in patients without nystagmus was lower (12.6±9.5months) compared to nystagmus without FMN (25.6±23.2) and FMN (29.5±20.4) groups (p = 0.006). Patients without nystagmus had better stereopsis at the end of treatment (2.3±0.84logarcsecs) compared to nystagmus without FMN (2.6±0.84) group (p = 0.003). The majority of patients with FMN (8/11) had absent stereopsis. BCEA of the amblyopic eye was higher in patients with greater residual visual acuity deficits in patients without nystagmus. No such association was seen in Nystagmus no FMN and FMN groups. Increased amplitude of fast FEMs, increased eye position variance and eye velocity of slow FEMs were seen in patients who had received longer duration of part time patching therapy and in those with greater residual amblyopia, and poor stereopsis at the end of treatment.Assessment of FEM waveforms and fast and slow FEM characteristics are important measures while describing fixation instability in amblyopia. Several FEM abnormalities were associated with stereo-acuity and visual acuity deficits and treatment duration in patients with amblyopia treated with part time patching therapy.CONCLUSIONSAssessment of FEM waveforms and fast and slow FEM characteristics are important measures while describing fixation instability in amblyopia. Several FEM abnormalities were associated with stereo-acuity and visual acuity deficits and treatment duration in patients with amblyopia treated with part time patching therapy. |
| Audience | Academic |
| Author | Murray, Jordan Nucci, Paolo Scaramuzzi, Matteo Otero-Millan, Jorge Ghasia, Fatema F. Shaikh, Aasef G. |
| AuthorAffiliation | 1 Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States of America Faculty of Medicine, Cairo University, EGYPT 6 Case Medical Center, Case Western Reserve University, Cleveland, OH, United States of America 2 Department of Neuroscience, Unit of Ophthalmology, Istituto Giannina Gaslini, Genoa, Italy 4 Department of Neurology, The Johns Hopkins University, Baltimore, MD, United States of America 3 DISCCO, University of Milan, Milan, Italy 5 Daroff—Dell’Osso Ocular Motility Laboratory, Cleveland, OH, United States of America |
| AuthorAffiliation_xml | – name: 3 DISCCO, University of Milan, Milan, Italy – name: 4 Department of Neurology, The Johns Hopkins University, Baltimore, MD, United States of America – name: 1 Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States of America – name: 5 Daroff—Dell’Osso Ocular Motility Laboratory, Cleveland, OH, United States of America – name: Faculty of Medicine, Cairo University, EGYPT – name: 6 Case Medical Center, Case Western Reserve University, Cleveland, OH, United States of America – name: 2 Department of Neuroscience, Unit of Ophthalmology, Istituto Giannina Gaslini, Genoa, Italy |
| Author_xml | – sequence: 1 givenname: Matteo orcidid: 0000-0003-2270-1732 surname: Scaramuzzi fullname: Scaramuzzi, Matteo – sequence: 2 givenname: Jordan surname: Murray fullname: Murray, Jordan – sequence: 3 givenname: Jorge surname: Otero-Millan fullname: Otero-Millan, Jorge – sequence: 4 givenname: Paolo surname: Nucci fullname: Nucci, Paolo – sequence: 5 givenname: Aasef G. surname: Shaikh fullname: Shaikh, Aasef G. – sequence: 6 givenname: Fatema F. orcidid: 0000-0001-8993-2709 surname: Ghasia fullname: Ghasia, Fatema F. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32790721$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk9uK2zAQhk3Z0j20b1BaQ6G0F0llS7asvSiEpYeFhS093YqxPE60yFJqyWnzBn3sKom3JMtSii8szXz_L82gOU2OrLOYJE8zMs0oz97cuKG3YKbLGJ6SnHLKygfJSSZoPilzQo_21sfJqfc3hBS0KstHyTHNuSA8z06S35-gD2nQHaZLCGqh7TwNPULo0IbUDUG5Dn2qbRpzpunRpj91WKTQ1WbtlhrGrW22iyhI28FrZ9MOTIMrNG65tbJrH2DeDf48ndkU15h2boXblA9Ds36cPGzBeHwy_s-Sb-_ffb34OLm6_nB5MbuaqFLkYYIZxQyrtoKaZqIomBANINYNrQrBFa1rQZmqoK3api6ogKblGUPali1hNXB6ljzf-S6N83Jsopc5o4zwqizySFzuiMbBjVz2uoN-LR1ouQ24fi5jz7QyKNu6JkVVAgUCrCkASF5xxQgRBVdQkOj1djxtqDtsVCy3B3NgepixeiHnbiU5ywtRFtHg1WjQux8D-iA77RUaAxbdsLs347Sim3u_uIPeX91IzSEWoG3r4rlqYypnJc0ZyQUXkZreQ8WvwU6r-OJaHeMHgtcHgsgE_BXmMHgvL798_n_2-vsh-3KPXSCYsPDODCE-MX8IPtvv9N8W3z71CJzvANU773tspdIBNj6xNG1kRuRmrm6bJjdzJce5imJ2R3zr_0_ZH3MJKjw |
| CitedBy_id | crossref_primary_10_1016_j_jns_2022_120373 crossref_primary_10_1038_s41598_020_79077_5 crossref_primary_10_1167_iovs_63_2_33 crossref_primary_10_2147_EB_S300454 crossref_primary_10_1038_s41598_021_93919_w crossref_primary_10_1007_s00221_024_06936_2 crossref_primary_10_3390_life13071517 crossref_primary_10_1016_j_jns_2022_120438 crossref_primary_10_1016_j_preteyeres_2021_101014 crossref_primary_10_1167_iovs_65_3_19 crossref_primary_10_1167_iovs_65_14_11 |
| Cites_doi | 10.1016/j.jaapos.2009.03.002 10.1113/jphysiol.1970.sp009022 10.1016/j.ophtha.2009.10.014 10.1001/archopht.123.4.437 10.1167/iovs.12-11054 10.1007/BF00153506 10.1016/j.ophtha.2016.06.042 10.1136/bjophthalmol-2017-310346 10.1001/archopht.1979.01020020325008 10.1097/WNO.0b013e3181dfa9ca 10.1167/iovs.18-24794 10.1167/8.14.16 10.1016/j.jaapos.2005.10.002 10.1016/j.jaapos.2006.06.010 10.1016/j.preteyeres.2012.11.001 10.1371/journal.pone.0175295 10.1038/nrn1348 10.1016/j.ophtha.2015.04.025 10.1371/journal.pone.0149953 10.1016/0006-8993(75)90809-4 10.1167/iovs.15-17896 10.1016/j.ophtha.2006.01.069 10.1001/archopht.1968.00980050354011 10.1016/j.visres.2006.09.014 10.1001/jamaophthalmol.2016.4262 10.1371/journal.pone.0056556 10.1007/978-3-030-31407-1_13 10.1016/j.jaapos.2010.10.004 10.1167/14.2.18 10.1016/S0002-9394(14)74174-1 10.1016/j.jcjo.2012.05.002 10.1163/187847611X620955 10.1016/j.visres.2015.01.016 10.1016/j.ophtha.2014.07.021 10.1016/j.neuroscience.2008.06.070 10.1001/archopht.1968.00980050659014 10.1016/j.ophtha.2003.08.001 10.1016/j.tins.2009.05.006 10.1152/jn.1965.28.6.1060 10.1167/8.14.15 10.1016/j.exer.2018.07.013 10.1038/nn.2663 10.1067/mpa.2002.126491 10.1016/j.ajo.2017.11.017 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2020 Public Library of Science 2020 Scaramuzzi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 Scaramuzzi et al 2020 Scaramuzzi et al |
| Copyright_xml | – notice: COPYRIGHT 2020 Public Library of Science – notice: 2020 Scaramuzzi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2020 Scaramuzzi et al 2020 Scaramuzzi et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0237346 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing & Allied Health Database (NC LIVE) Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest Health & Medical Collection (NC LIVE) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database (NC LIVE) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database Health & Medical Collection (Alumni Edition) Proquest Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Treatment outcomes in amblyopic patients with and without FMN |
| EISSN | 1932-6203 |
| ExternalDocumentID | 2434078652 oai_doaj_org_article_fbb0586a3a0a4d5aa0287c400957ca50 PMC7425965 A632402979 32790721 10_1371_journal_pone_0237346 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | United States United States--US Italy |
| GeographicLocations_xml | – name: United States – name: United States--US – name: Italy |
| GrantInformation_xml | – fundername: NEI NIH HHS grantid: P30 EY025585 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM ADRAZ BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG PMFND 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI RC3 7X8 5PM PUEGO - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c692t-e13e1e8f8ab31955499daeebd38597c3bb934c8af8fdb539adf714e3f6f04ba73 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:12:25 EST 2021 Wed Aug 27 01:26:45 EDT 2025 Thu Aug 21 13:32:56 EDT 2025 Thu Jul 10 22:42:04 EDT 2025 Fri Jul 25 11:23:47 EDT 2025 Tue Jun 17 21:29:56 EDT 2025 Tue Jun 10 20:26:58 EDT 2025 Fri Jun 27 04:15:40 EDT 2025 Fri Jun 27 05:05:18 EDT 2025 Thu May 22 21:22:48 EDT 2025 Thu Apr 03 07:04:33 EDT 2025 Tue Jul 01 00:32:02 EDT 2025 Thu Apr 24 23:00:57 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-e13e1e8f8ab31955499daeebd38597c3bb934c8af8fdb539adf714e3f6f04ba73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. These authors also contributed equally to this work. |
| ORCID | 0000-0001-8993-2709 0000-0003-2270-1732 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0237346 |
| PMID | 32790721 |
| PQID | 2434078652 |
| PQPubID | 1436336 |
| PageCount | e0237346 |
| ParticipantIDs | plos_journals_2434078652 doaj_primary_oai_doaj_org_article_fbb0586a3a0a4d5aa0287c400957ca50 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7425965 proquest_miscellaneous_2434473832 proquest_journals_2434078652 gale_infotracmisc_A632402979 gale_infotracacademiconefile_A632402979 gale_incontextgauss_ISR_A632402979 gale_incontextgauss_IOV_A632402979 gale_healthsolutions_A632402979 pubmed_primary_32790721 crossref_citationtrail_10_1371_journal_pone_0237346 crossref_primary_10_1371_journal_pone_0237346 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-08-13 |
| PublicationDateYYYYMMDD | 2020-08-13 |
| PublicationDate_xml | – month: 08 year: 2020 text: 2020-08-13 day: 13 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2020 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | CE Windsor (pone.0237346.ref046) 1968; 80 L Tychsen (pone.0237346.ref029) 2019 LF Dell’Osso (pone.0237346.ref040) 1979; 97 L Tychsen (pone.0237346.ref024) 2010; 30 XG Troncoso (pone.0237346.ref007) 2008; 8 M Scaramuzzi (pone.0237346.ref034) 2019 Pediatric Eye Disease Investigator Group (pone.0237346.ref056) 2015; 122 V Abadi R (pone.0237346.ref035) 2000; 41 KR Kelly (pone.0237346.ref033) 2019; 183 D Chen (pone.0237346.ref060) 2018; 59 W Ridder (pone.0237346.ref022) 2019 S Martinez-Conde (pone.0237346.ref004) 2009; 32 TN Wiesel (pone.0237346.ref026) 1965; 28 FM Costela (pone.0237346.ref008) 2013; 1 A Hasany (pone.0237346.ref030) 2008; 156 S Duke-Elder (pone.0237346.ref037) 1973 OH Pirdankar (pone.0237346.ref018) 2016; 57 LF Dell’Osso (pone.0237346.ref045) 1985; 29 RM Steinman (pone.0237346.ref042) 1982; 1 X-FF Shi (pone.0237346.ref049) 2012; 30 V Subramanian (pone.0237346.ref017) 2013; 54 MM Scheiman (pone.0237346.ref003) 2005; 123 SR Lambert (pone.0237346.ref031) 2006; 10 J Otero-Millan (pone.0237346.ref041) 2014; 14 pone.0237346.ref039 AG Shaikh (pone.0237346.ref013) 2017; 12 RW Hertle (pone.0237346.ref044) 2002; 6 GK von Noorden (pone.0237346.ref036) 1987; 103 EE Birch (pone.0237346.ref011) 2013; 33 ML Crawford (pone.0237346.ref027) 1975; 84 Pediatric Eye Disease Investigator Group Writing Committee (pone.0237346.ref043) 2010; 117 MX Repka (pone.0237346.ref058) 2009; 13 S Martinez-Conde (pone.0237346.ref005) 2004; 5 Pediatric Eye Disease Investigator Group (pone.0237346.ref002) 2006; 113 STL Chung (pone.0237346.ref012) 2015; 114 Pediatric Eye Disease Investigator Group (pone.0237346.ref057) 2014; 121 Pediatric Eye Disease Investigator Group (pone.0237346.ref055) 2016; 123 E Castet (pone.0237346.ref050) 2012; 25 DH Hubel (pone.0237346.ref025) 1970; 206 Pediatric Eye Disease Investigator Group (PEDIG) (pone.0237346.ref054) 2002 JM Holmes (pone.0237346.ref053) 2016; 134 E Castet (pone.0237346.ref021) 2012; 25 EE Birch (pone.0237346.ref032) 2006; 10 CE Windsor (pone.0237346.ref047) 1968; 80 HK Falkenberg (pone.0237346.ref009) 2007; 47 AMF Wong (pone.0237346.ref014) 2012; 47 H-K Ko (pone.0237346.ref006) 2010; 13 VM Manh (pone.0237346.ref038) 2018; 186 HJ Simonsz (pone.0237346.ref023) 1989; 72 RM Schneider (pone.0237346.ref052) 2013; 8 AF Macedo (pone.0237346.ref010) 2008; 8 KR Kelly (pone.0237346.ref059) 2015 EE Birch (pone.0237346.ref048) 2010; 14 RJ Tusa (pone.0237346.ref028) 2002 JM Holmes (pone.0237346.ref001) 2003; 110 AG Shaikh (pone.0237346.ref019) 2016; 11 JR Leigh (pone.0237346.ref051) 2019 HE Bedell (pone.0237346.ref016) 1990; 31 FF Ghasia (pone.0237346.ref015) 2018; 102 SL Kang (pone.0237346.ref020) 2019 |
| References_xml | – volume: 13 start-page: 258 issue: 3 year: 2009 ident: pone.0237346.ref058 article-title: Treatment of severe amblyopia with weekend atropine: Results from 2 randomized clinical trials publication-title: J AAPOSJun doi: 10.1016/j.jaapos.2009.03.002 – start-page: 346 volume-title: InAnnals of the New York Academy of Sciences year: 2002 ident: pone.0237346.ref028 – volume: 29 start-page: 351 issue: 4 year: 1985 ident: pone.0237346.ref045 article-title: Congenital, latent and manifest latent nystagmus—similarities, differences and relation to strabismus publication-title: Jpn J Ophthalmol – volume: 206 start-page: 419 issue: 2 year: 1970 ident: pone.0237346.ref025 article-title: The period of susceptibility to the physiological effects of unilateral eye closure in kittens publication-title: J Physiol doi: 10.1113/jphysiol.1970.sp009022 – volume: 117 start-page: 998 issue: 5 year: 2010 ident: pone.0237346.ref043 article-title: A randomized trial comparing Bangerter filters and patching for the treatment of moderate amblyopia in children publication-title: Ophthalmology doi: 10.1016/j.ophtha.2009.10.014 – start-page: 515 volume-title: Amblyopic children read more slowly than controls under natural, binocular reading conditions Presented at the 41st Annual Meeting of the American Association for Pediatric Ophthalmology and Strabismus, New Orleans, Louisiana, March 25–29, 2015 year: 2015 ident: pone.0237346.ref059 – volume: 123 start-page: 437 issue: 4 year: 2005 ident: pone.0237346.ref003 article-title: Randomized trial of treatment of amblyopia in children aged 7 to 17 years publication-title: Arch Ophthalmol doi: 10.1001/archopht.123.4.437 – volume: 54 start-page: 1998 issue: 3 year: 2013 ident: pone.0237346.ref017 article-title: A quantitative study of fixation stability in amblyopia publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.12-11054 – start-page: 524 year: 2019 ident: pone.0237346.ref022 article-title: Fixation Stability Before and After Amblyopia Therapy. publication-title: Investigative Ophthalmology & Visual Science – volume: 72 start-page: 375 issue: 3–4 year: 1989 ident: pone.0237346.ref023 article-title: The effect of prolonged monocular occlusion on latent nystagmus in the treatment of amblyopia publication-title: Doc Ophthalmol doi: 10.1007/BF00153506 – volume: 123 start-page: 2127 issue: 10 year: 2016 ident: pone.0237346.ref055 article-title: A Randomized Trial Evaluating Short-term Effectiveness of Overminus Lenses in Children 3 to 6 Years of Age with Intermittent Exotropia publication-title: Ophthalmology doi: 10.1016/j.ophtha.2016.06.042 – volume: 102 start-page: 253 issue: 2 year: 2018 ident: pone.0237346.ref015 article-title: Abnormal fixational eye movements in strabismus publication-title: Br J Ophthalmol doi: 10.1136/bjophthalmol-2017-310346 – volume: 97 start-page: 1877 issue: 10 year: 1979 ident: pone.0237346.ref040 article-title: Latent, manifest latent, and congenital nystagmus publication-title: Arch Ophthalmol doi: 10.1001/archopht.1979.01020020325008 – volume: 30 start-page: 276 issue: 3 year: 2010 ident: pone.0237346.ref024 article-title: The neural mechanism for Latent (fusion maldevelopment) nystagmus publication-title: J NeuroophthalmolSep doi: 10.1097/WNO.0b013e3181dfa9ca – volume: 59 start-page: 4506 issue: 11 year: 2018 ident: pone.0237346.ref060 article-title: Visual Search in Amblyopia: Abnormal Fixational Eye Movements and Suboptimal Sampling Strategies publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.18-24794 – volume: 8 issue: 14 year: 2008 ident: pone.0237346.ref010 article-title: The effect of retinal image slip on peripheral visual acuity publication-title: J Vis doi: 10.1167/8.14.16 – volume: 10 start-page: 30 issue: 1 year: 2006 ident: pone.0237346.ref031 article-title: Is there a latent period for the surgical treatment of children with dense bilateral congenital cataracts? publication-title: J AAPOS Off Publ Am Assoc Pediatr Ophthalmol Strabismus doi: 10.1016/j.jaapos.2005.10.002 – volume: 10 start-page: 409 issue: 5 year: 2006 ident: pone.0237346.ref032 article-title: Long-Term Motor and Sensory Outcomes After Early Surgery for Infantile Esotropia publication-title: J AAPOS doi: 10.1016/j.jaapos.2006.06.010 – volume: 33 start-page: 67 year: 2013 ident: pone.0237346.ref011 article-title: Amblyopia and binocular vision publication-title: Prog Retin Eye Res doi: 10.1016/j.preteyeres.2012.11.001 – volume: 12 issue: 4 year: 2017 ident: pone.0237346.ref013 article-title: Fixational saccades are more disconjugate in adults than in children publication-title: PLoS One doi: 10.1371/journal.pone.0175295 – volume: 5 start-page: 229 year: 2004 ident: pone.0237346.ref005 article-title: The role of fixational eye movements in visual perception publication-title: Nature Reviews Neuroscience doi: 10.1038/nrn1348 – volume: 122 start-page: 1718 issue: 8 year: 2015 ident: pone.0237346.ref056 article-title: A Randomized Trial Comparing Part-time Patching with Observation for Intermittent Exotropia in Children 12 to 35 publication-title: Months of Age. Ophthalmology doi: 10.1016/j.ophtha.2015.04.025 – volume: 11 issue: 3 year: 2016 ident: pone.0237346.ref019 article-title: Abnormal Fixational Eye Movements in Amblyopia publication-title: PLoS One doi: 10.1371/journal.pone.0149953 – volume: 84 start-page: 150 issue: 1 year: 1975 ident: pone.0237346.ref027 article-title: Physiological consequences of unilateral and bilateral eye closure in macaque monkeys: some further observations publication-title: Brain Res doi: 10.1016/0006-8993(75)90809-4 – volume: 41 start-page: 3805 issue: 12 year: 2000 ident: pone.0237346.ref035 article-title: Waveform characteristics of manifest latent nystagmus. publication-title: Investig Ophthalmol Vis Sci – volume: 57 start-page: 1087 issue: 3 year: 2016 ident: pone.0237346.ref018 article-title: Influence of target parameters on fixation stability in normal and strabismic monkeys publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.15-17896 – year: 2019 ident: pone.0237346.ref020 article-title: Fixational eye movement waveforms in amblyopia: Characteristics of fast and slow eye movements publication-title: J Eye Mov Res – start-page: 824 year: 1973 ident: pone.0237346.ref037 article-title: Ocular Motility and Strabismus. In: Mosby C V., editor publication-title: System of Ophthalmology – volume: 113 start-page: 904 issue: 6 year: 2006 ident: pone.0237346.ref002 article-title: A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children publication-title: Ophthalmology doi: 10.1016/j.ophtha.2006.01.069 – volume: 80 start-page: 352 issue: 3 year: 1968 ident: pone.0237346.ref047 article-title: Modification of Latent Nystagmus: Part II publication-title: Arch Ophthalmol doi: 10.1001/archopht.1968.00980050354011 – volume: 47 start-page: 126 issue: 1 year: 2007 ident: pone.0237346.ref009 article-title: Acuity, crowding, reading and fixation stability publication-title: Vision Res doi: 10.1016/j.visres.2006.09.014 – volume: 134 start-page: 1391 issue: 12 year: 2016 ident: pone.0237346.ref053 article-title: Effect of a Binocular iPad Game vs Part-time Patching in Children Aged 5 to 12 Years With Amblyopia: A Randomized Clinical Trial publication-title: JAMA Ophthalmol doi: 10.1001/jamaophthalmol.2016.4262 – volume: 8 start-page: e56556 issue: 2 year: 2013 ident: pone.0237346.ref052 article-title: Neurological Basis for Eye Movements of the Blind publication-title: PLoS One doi: 10.1371/journal.pone.0056556 – volume: 1 start-page: e119 year: 2013 ident: pone.0237346.ref008 article-title: Microsaccades restore the visibility of minute foveal targets publication-title: PeerJInternet] – volume: 1 start-page: 97 issue: 2 year: 1982 ident: pone.0237346.ref042 article-title: The precision of gaze. A review publication-title: Hum Neurobiol – start-page: 255 volume-title: Advances in Translational Neuroscience of Eye Movement Disorders year: 2019 ident: pone.0237346.ref029 doi: 10.1007/978-3-030-31407-1_13 – volume: 14 start-page: 494 issue: 6 year: 2010 ident: pone.0237346.ref048 article-title: The clinical profile of amblyopia in children younger than 3 years of age publication-title: J AAPOS Off Publ Am Assoc Pediatr Ophthalmol Strabismus doi: 10.1016/j.jaapos.2010.10.004 – volume: 14 start-page: 18 issue: 2 year: 2014 ident: pone.0237346.ref041 article-title: Unsupervised clustering method to detect microsaccades publication-title: J Vis doi: 10.1167/14.2.18 – start-page: 268 year: 2002 ident: pone.0237346.ref054 publication-title: A Randomized Trial of Atropine vs Patching for Treatment of Moderate Amblyopia in Children | Ophthalmology | JAMA Ophthalmology | JAMA Network – volume: 103 start-page: 87 issue: 1 year: 1987 ident: pone.0237346.ref036 article-title: Latent nystagmus and strabismic amblyopia publication-title: Am J Ophthalmol doi: 10.1016/S0002-9394(14)74174-1 – volume: 47 start-page: 399 issue: 5 year: 2012 ident: pone.0237346.ref014 article-title: New concepts concerning the neural mechanisms of amblyopia and their clinical implications publication-title: Can J Ophthalmol doi: 10.1016/j.jcjo.2012.05.002 – volume: 25 start-page: 449 issue: 5 year: 2012 ident: pone.0237346.ref021 article-title: Quantifying eye stability during a fixation task: a review of definitions and methods. publication-title: Seeing Perceiving doi: 10.1163/187847611X620955 – volume: 114 start-page: 87 year: 2015 ident: pone.0237346.ref012 article-title: Characteristics of fixational eye movements in amblyopia: Limitations on fixation stability and acuity publication-title: Vision Res doi: 10.1016/j.visres.2015.01.016 – volume: 121 start-page: 2299 issue: 12 year: 2014 ident: pone.0237346.ref057 article-title: A randomized trial comparing part-time patching with observation for children 3 to 10 years of age with intermittent exotropia publication-title: Ophthalmology doi: 10.1016/j.ophtha.2014.07.021 – volume: 156 start-page: 403 issue: 2 year: 2008 ident: pone.0237346.ref030 article-title: Duration of binocular decorrelation in infancy predicts the severity of nasotemporal pursuit asymmetries in strabismic macaque monkeys publication-title: Neuroscience doi: 10.1016/j.neuroscience.2008.06.070 – volume: 31 start-page: 968 issue: 5 year: 1990 ident: pone.0237346.ref016 article-title: Fixational drift and nasal-temporal pursuit asymmetries in strabismic amblyopes publication-title: Invest Ophthalmol Vis Sci – volume: 80 start-page: 657 issue: 5 year: 1968 ident: pone.0237346.ref046 article-title: Modification of Latent Nystagmus: Part I publication-title: Arch Ophthalmol doi: 10.1001/archopht.1968.00980050659014 – ident: pone.0237346.ref039 – volume: 110 start-page: 2075 issue: 11 year: 2003 ident: pone.0237346.ref001 article-title: A randomized trial of prescribed patching regimens for treatment of severe amblyopia in children publication-title: Ophthalmology doi: 10.1016/j.ophtha.2003.08.001 – volume: 32 start-page: 463 issue: 9 year: 2009 ident: pone.0237346.ref004 article-title: Microsaccades: a neurophysiological analysis publication-title: Trends Neurosci doi: 10.1016/j.tins.2009.05.006 – volume: 28 start-page: 1060 issue: 6 year: 1965 ident: pone.0237346.ref026 article-title: Extent of recovery from the effects of visual deprivation in kittens publication-title: J Neurophysiol doi: 10.1152/jn.1965.28.6.1060 – volume: 8 start-page: 15 issue: 14 year: 2008 ident: pone.0237346.ref007 article-title: Microsaccades counteract perceptual filling-in publication-title: J Vis doi: 10.1167/8.14.15 – volume: 183 start-page: 29 year: 2019 ident: pone.0237346.ref033 article-title: Fixation instability during binocular viewing in anisometropic and strabismic children publication-title: Exp Eye Res doi: 10.1016/j.exer.2018.07.013 – volume: 25 start-page: 449 issue: 5 year: 2012 ident: pone.0237346.ref050 article-title: Quantifying eye stability during a fixation task: A review of definitions and methods publication-title: Seeing Perceiving doi: 10.1163/187847611X620955 – volume-title: Neuropsychologia year: 2019 ident: pone.0237346.ref051 – volume: 13 start-page: 1549 issue: 12 year: 2010 ident: pone.0237346.ref006 article-title: Microsaccades precisely relocate gaze in a high visual acuity task publication-title: Nat Neurosci doi: 10.1038/nn.2663 – volume: 6 start-page: 201 issue: 4 year: 2002 ident: pone.0237346.ref044 article-title: A next step in naming and classification of eye movement disorders and strabismus publication-title: J AAPOS doi: 10.1067/mpa.2002.126491 – volume: 186 start-page: 104 year: 2018 ident: pone.0237346.ref038 article-title: A Randomized Trial of a Binocular iPad Game Versus Part-Time Patching in Children Aged 13 to 16 Years With Amblyopia publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2017.11.017 – volume: 30 start-page: 445 issue: 6 year: 2012 ident: pone.0237346.ref049 article-title: Fixational saccadic eye movements are altered in anisometropic amblyopia publication-title: Restor Neurol Neurosci – start-page: 235 volume-title: : Progress in Brain Research year: 2019 ident: pone.0237346.ref034 |
| SSID | ssj0053866 |
| Score | 2.3996258 |
| Snippet | We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching... Purpose We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time... PURPOSE:We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time... Purpose We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0237346 |
| SubjectTerms | Abnormalities Acuity Amblyopia Amblyopia - complications Amblyopia - physiopathology Amblyopia - therapy Astigmatism Biology and Life Sciences Bivariate analysis Care and treatment Child Child, Preschool Children Clinical outcomes Eye Eye Movement Measurements Eye Movements Fixation Flavin mononucleotide Humans Infant Laboratories Medicine and Health Sciences Motility Nystagmus Nystagmus, Pathologic - complications Nystagmus, Pathologic - physiopathology Part time Patching Patient outcomes Patients Pediatric diseases Physical Sciences Research and Analysis Methods Retrospective Studies Saccadic eye movements Social Sciences Strabismus Surgery Therapy Treatment Outcome Visual acuity Waveforms |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggyquBthiEBBzSbmI7TrgtiKog8RBQ1JtlO05ZaTeJSHLYf8DPZibxhg2qVA7cdtdjazMznhlPxt8Q8sxKJue50KGO4zzkmkdhCm4ujJgFadsoKzSmBj58TM7O-fsLcbHT6gtrwgZ44IFxJ4Uxc5Emmum55rCoBocoLcfQQCKcP1pf8Hnbw9Rgg2EXJ4m_KMdkdOLlclxXpTsGLyUZBrw7jqjH6x-t8qxeVc1VIefflZM7ruj0NrnlY0i6GP77Hrnhyjtkz-_Shr7wUNIv75Jfn-EBKfaPpzXYXMw20bG0nFZdC_oGM5Yl3V7qppiYpXptVpuqXmr_tcz7DzCBFh3m1-har_I_9Ua03ECUebnumld0UVK3cXRd9UjkLe0BbO-R89O3396chb73QmiTLG5DFzEXubRItYFNKvAUmWvnTM5SOIJYZkzGuE11kRa5ESzTeSEj7liRFHNutGT3yawEbu8TajPubGKsjk3KBYcFYUnBEVpO2IiZgLCtIJT1wOTYH2Ol-rdtEg4oA18Vik958QUkHGfVAzDHNfSvUcYjLcJq9z-AsimvbOo6ZQvIY9QQNdxRHY2DWiDoPbYBywLytKdAaI0Sa3cuddc06t2n7_9A9PXLhOi5JyoqYIfV_r4EPBNCdk0oDyaUYCDsZHgf9XnLlUbFnOHb20TEMHOr41cPPxmHcVGsxytd1Q00XDJwBwF5MGyJkbMslhmi7gVETjbLhPXTkXL5o0c2l-BBskQ8_B-yekRuxpgbQfhidkBm7c_OHUIA2Zqj3lb8BjPech0 priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegvPCCGF8LbGAQEvCQrYmdOOEFFUQZSHwIGNpbZDtOqdQ62dI89D_gz-YucbIFTcBbW5-j9M734fP5d4Q81YKJaR5JX4Zh7nPJAz8BN-cHTIO0dZAWElMDHz_FR8f8w0l04hJutSur7G1ia6jzUmOO_DDkDI-c4ih8VZ362DUKT1ddC42r5FoAngZLupL5u94Sgy7Hsbsux0Rw6KRzUJXWHICvEgzD3gvuqEXtH2zzpFqV9WWB55_1kxcc0vwmueEiSTrrRL9Drhh7i-w4Xa3pcwco_eI2-fUF1gfFLvK0AsuLOSc6FJjTstkAB2DG0tL-ajfF9CyVa7XaltVSuq82bz_ABFo0mGWja7nKz6uOqN1CrLlYN_VLOrPUbA1dly0e-Ya2MLZ3yPH87fc3R77rwODrOA03vgmYCUxSJFKBqka4l8ylMSpnCWxENFMqZVwnskiKXEUslXkhAm5YERdTrqRgd8nEArd3CdUpNzpWWoYq4RGHB8IjI44Ac5EOmPII6wWRaQdPjl0yVll75iZgm9LxNUPxZU58HvGHWVUHz_EP-tco44EWwbXbH8qzReZ0NSuUmkZJLJmcSg7rWEIMJjTHaFRgBwmPPMIVknU3VQcTkc0Q-h6bgaUeedJSIMCGxQqehWzqOnv_-cd_EH37OiJ65oiKEtihpbs1Af8JgbtGlHsjSjATejS8i-u550qdnSsUzOzX-OXDj4dhfChW5VlTNh0NFwycgkfudSoxcJaFIkXsPY-IkbKMWD8escufLb65AD-SxtH9v7_WA3I9xNwHwhOzPTLZnDVmHwLEjXrYWoHfBaNptw priority: 102 providerName: ProQuest |
| Title | Part time patching treatment outcomes in children with amblyopia with and without fusion maldevelopment nystagmus: An eye movement study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32790721 https://www.proquest.com/docview/2434078652 https://www.proquest.com/docview/2434473832 https://pubmed.ncbi.nlm.nih.gov/PMC7425965 https://doaj.org/article/fbb0586a3a0a4d5aa0287c400957ca50 http://dx.doi.org/10.1371/journal.pone.0237346 |
| Volume | 15 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELe2TkJ7QYyvBUYxCAl4SNXETpwgIdRNKwNpYxoM9S2yHadUapPSNBL9D_izucsXBHWClyip7yz1fOc7n-3fEfJCCyaGsSdt6bqxzSV37ADcnO0wDaOtnTCRmBo4v_DPrvnHiTfZIU3N1lqA-dalHdaTul7NBz--b96Bwb8tqzYIp2EaLLPUDMAHCcb9XbIHvklgTYNz3u4rgHX7fn2B7ibOfXKLuSJE3LCOryoh_duJu7ecZ_m2qPTvw5V_eKvxHXK7DjPpqNKLA7Jj0rvkoDbknL6q0aZf3yM_L0F5KJaYp0uYljEhRdvT5zQr1qCSwDFLaXPvm2LulsqFmm-y5UzWn2lcvgADTQpMwdGFnMe_jyTRdAOB6HRR5G_oKKVmY-giK8HK17TEuL1PrsenX07O7Lo8g6390F3bxmHGMUESSAV27OFCM5bGqJgFsErRTKmQcR3IJEhi5bFQxolwuGGJnwy5koI9IL0UBH9IqA650b7S0lUB9zh0CF16HNHnPO0wZRHWDESka-xyLKExj8oNOQFrmEquEY5kVI-kReyWa1lhd_yD_hjHuKVF5O3yh2w1jWpDjhKlhl7gSyaHkoOSSwjQhOYYqgosL2GRp6ghUXWNtZ0_ohHi4mOlsNAiz0sKRN9I8XjPVBZ5Hn349PU_iD5fdYhe1kRJBuLQsr5SAf8JUb06lEcdSphDdKf5EPW5kUoeuZzhBq_vucDZ6Pj25mdtM3aKR_ZSkxUVDRcMPIZFHlYm0Uq2MTCLiI6xdETfbUln30rwcwFOJvS9Rzf2-Zjsu5gTQdhidkR661VhnkDguFZ9sismAp7BiYPP8fs-2Ts-vbi86pepmH45V_wCma90hw |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdGeYAXxPhaYTCDQMBDtiZ24gQJofJRVvYBGhvaW7Adp1Rqk7A0Qv0P-Gv4G7nL1xY0AS97a-uzld6d786X8-8IeawFE4PIlZZ0nMjiktuWD27OspkGaWs7iCWmBvb2ve0j_uHYPV4hv5q7MFhW2djE0lBHqcYc-ZbDGb5y8lznVfbdwq5R-Ha1aaFRqcWOWf6AI1v-cvwW5PvEcUbvDt9sW3VXAUt7gbOwjM2MbfzYlwrUz8XzUSSNURHzIbjWTKmAce3L2I8j5bJARrGwuWGxFw-4koLBupfIZc7Ak-PN9NH7xvKD7fC8-noeE_ZWrQ2bWZqYTfCNgmGYfcb9lV0CWl_Qy2Zpfl6g-2e95hkHOLpOrtWRKx1WqrZKVkxyg6zWtiGnz2oA6-c3yc9PoI8Uu9bTDCw95rhoW9BO02IBHIcZ04Q2V8kppoOpnKvZMs2msv6aROUHmEDjArN6dC5n0WmVE02WENtO5kX-gg4TapaGztMS_3xBS9jcW-ToQmRzm_QS4PYaoTrgRntKS0f53OWwICzpcgS0c7XNVJ-wRhChruHQsSvHLCzf8Qk4FlV8DVF8YS2-PrHaWVkFB_IP-tco45YWwbzLH9KTSVjbhjBWauD6nmRyIDnsGwkxn9Aco1-BHSv6ZAM1JKxuxrYmKRwi1D42Hwv65FFJgYAeCVYMTWSR5-H445f_IPp80CF6WhPFKbBDy_qWBvwnBArrUK53KMEs6c7wGupzw5U8PN3AMLPR8fOHH7bDuChWASYmLSoaLhg4oT65U22JlrPMEQFi_fWJ6GyWDuu7I8n0W4mnLsBvBZ579--PtUGubB_u7Ya74_2de-Sqg3kXhEZm66S3OCnMfQhOF-pBaREo-XrRJug3ASCogQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELdGkRAviPFvhcEMAgEPWZvYiRMkhMpGtTIYEzC0t2A7TqnUJmVphfoN-Ex8Ou4SJ1vQBLzsra3PVnN3vjtfzr8j5LEWTPQTXzrS8xKHS-46Ibg5x2UapK3dKJWYGnh_EOwd8bfH_vEa-VXfhcGyytomloY6yTXmyHseZ_jKKfC9XmrLIg53h6_m3x3sIIVvWut2GpWK7JvVDzi-FS9HuyDrJ543fPN5Z8-xHQYcHUTewjEuM64J01AqUEUfz0qJNEYlLIRAWzOlIsZ1KNMwTZTPIpmkwuWGpUHa50oKButeIpfheUPcY-FOU14CdiQI7FU9Jtye1YzteZ6ZbfCTgmHIfcYVlh0DGr_QmU_z4ryg98_azTPOcHidXLNRLB1UardO1kx2g6xbO1HQZxbM-vlN8vMQdJNiB3s6B6uP-S7aFLfTfLkA7sOMSUbra-UUU8NUztR0lc8n0n7NkvIDTKDpEjN8dCanyWnFE81WEOeOZ8viBR1k1KwMneUlFvqClhC6t8jRhcjmNulkwO0NQnXEjQ6Ulp4Kuc9hQVjS5whu52uXqS5htSBibaHRsUPHNC7f9wk4IlV8jVF8sRVflzjNrHkFDfIP-tco44YWgb3LH_KTcWztRJwq1ffDQDLZlxz2kIT4T2iOkbDA7hVdsoUaEle3ZBvzFA8Qdh8bkUVd8qikQHCPDLfJWC6LIh59-PIfRJ8-toieWqI0B3ZoaW9swDMhaFiLcrNFCSZKt4Y3UJ9rrhTx6WaGmbWOnz_8sBnGRbEiMDP5sqLhgoFD6pI71ZZoOMs8ESHuX5eI1mZpsb49kk2-ldjqAnxYFPh3__63tsgVMD7xu9HB_j1y1cMUDKIks03SWZwszX2IUxfqQWkQKPl60RboNxxjrII |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Part+time+patching+treatment+outcomes+in+children+with+amblyopia+with+and+without+fusion+maldevelopment+nystagmus%3A+An+eye+movement+study&rft.jtitle=PloS+one&rft.au=Scaramuzzi%2C+Matteo&rft.au=Murray%2C+Jordan&rft.au=Otero-Millan%2C+Jorge&rft.au=Nucci%2C+Paolo&rft.date=2020-08-13&rft.eissn=1932-6203&rft.volume=15&rft.issue=8&rft.spage=e0237346&rft_id=info:doi/10.1371%2Fjournal.pone.0237346&rft_id=info%3Apmid%2F32790721&rft.externalDocID=32790721 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |