Elevated High-Density Lipoprotein Cholesterol and Age-Related Macular Degeneration: The Alienor Study

• Published in: PloS one Vol. 9; no. 3; p. e90973
• Main Authors: Cougnard-Grégoire, Audrey, Delyfer, Marie-Noëlle, Korobelnik, Jean-François, Rougier, Marie-Bénédicte, Le Goff, Mélanie, Dartigues, Jean-François, Barberger-Gateau, Pascale, Delcourt, Cécile
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.03.2014; Public Library of Science (PLoS)
• Subjects: ABCA1 protein; Abnormalities; Age related diseases; Aged; Aged, 80 and over; Analysis; Anticholesteremic agents; Apolipoprotein E4; Apolipoproteins E - blood; Apolipoproteins E - genetics; ATP Binding Cassette Transporter 1 - blood; ATP Binding Cassette Transporter 1 - genetics; ATP-binding protein; Biology; Blood lipids; Body Mass Index; Cardiovascular diseases; Cholesterol; Cholesterol Ester Transfer Proteins - blood; Cholesterol Ester Transfer Proteins - genetics; Color vision; Complement Factor H - genetics; Complement Factor H - metabolism; Diabetes mellitus; Drug abuse; Drugs; Educational Status; Eye diseases; Female; Genes; Genetic aspects; Genetic polymorphisms; Geriatrics; Health risk assessment; High density lipoprotein; Humans; Hypolipidemic Agents - therapeutic use; Lipase - blood; Lipase - genetics; Lipid metabolism; Lipid Metabolism - genetics; Lipids; Lipoprotein Lipase - blood; Lipoprotein Lipase - genetics; Lipoproteins (high density); Lipoproteins (low density); Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Low density lipoprotein; Low density lipoproteins; Macular degeneration; Macular Degeneration - blood; Macular Degeneration - drug therapy; Macular Degeneration - genetics; Macular Degeneration - pathology; Male; Medical research; Medicine; Metabolism; Multivariate analysis; Older people; Pathogenesis; Physiological aspects; Polymorphism, Genetic; Population studies; Proteins - genetics; Proteins - metabolism; Regression analysis; Retina; Risk Factors; Severity of Illness Index; Smoking; Statistical analysis; Statistical analysis of data; Statistics; Triglycerides; Triglycerides - blood; France

Lipid metabolism and particularly high-density lipoprotein (HDL) may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with plasma HDL and other lipids, which may be confounded by the recently...