Dysbiosis in the oral bacterial and fungal microbiome of HIV-infected subjects is associated with clinical and immunologic variables of HIV infection

• Published in: PloS one Vol. 13; no. 7; p. e0200285
• Main Authors: Mukherjee, Pranab K., Chandra, Jyotsna, Retuerto, Mauricio, Tatsuoka, Curtis, Ghannoum, Mahmoud A., McComsey, Grace A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.07.2018; Public Library of Science (PLoS)
• Subjects: Abundance; Adult; Alcohols; Bacteria; Biofilms; Biology and Life Sciences; CD4 antigen; CD4 Lymphocyte Count; Clustering; Complications and side effects; Correlation; Correlation analysis; Deoxyribonucleic acid; Dermatology; DNA; DNA, Bacterial - genetics; DNA, Fungal - genetics; Dysbacteriosis; Dysbiosis; Dysbiosis - immunology; Dysbiosis - microbiology; Female; Frequency distribution; Fungi; Health aspects; HIV; HIV infections; HIV Infections - immunology; HIV Infections - microbiology; Human immunodeficiency virus; Humans; Immunologic research; Infections; Male; Markers; Medicine and Health Sciences; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Microbiota - genetics; Microorganisms; Middle Aged; Mouth - microbiology; Mycobiome - genetics; Obesity; Oral mucosa; Porphyromonas; Research and Analysis Methods; Risk factors; Sequence Analysis, DNA; Smoking; Smoking - adverse effects; Smoking cessation; Studies; Cleveland Ohio; United States > US; Ohio

The effect of smoking on microbial dysbiosis and the potential consequence of such shift on markers of HIV disease is unknown. Here we assessed the relationship of microbial dysbiosis with smoking and markers of HIV disease. Oral wash was collected from: (1) HIV-infected smokers (HIV-SM, n = 48), (2...