CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra

• Published in: PloS one Vol. 12; no. 10; p. e0186780
• Main Authors: Cheng, An-Chieh, Yang, Kuang-Yao, Chen, Nien-Jung, Hsu, Tsui-Ling, Jou, Ruwen, Hsieh, Shie-Liang, Tseng, Ping-Hui
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.10.2017; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Animals; Antigens; Bacteria; Biochemistry; Biology and Life Sciences; Cell activation; Cell Line; Cell walls; Chemokines; Cytokines; Development and progression; Fc receptors; Fusion protein; Gene Knockdown Techniques; Genetic aspects; Genomics; Granulocytes; Hot Temperature; Humans; IL-1β; Immune response; Immune system; Immunity; Immunology; Infections; Infectious diseases; Infiltration; Innate immunity; Kinases; Lectins; Lectins, C-Type - genetics; Lectins, C-Type - physiology; Leukemia; Life sciences; Lungs; Macrophages; Macrophages - enzymology; Macrophages - physiology; Male; MAP kinase; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Molecular biology; Mycobacterium tuberculosis; Mycobacterium tuberculosis - physiology; Neutrophils; Neutrophils - cytology; Pathogenesis; Pathogenicity; Pathogens; Pattern recognition; Pattern recognition receptors; Physiological aspects; Polysaccharides; Protein Kinases - metabolism; Proteins; Receptors; Receptors, Mitogen - genetics; Receptors, Mitogen - physiology; Research and Analysis Methods; Signal Transduction; Signaling; Syk protein; Tuberculosis; Taiwan

Tuberculosis is a fatal human infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis) that is prevalent worldwide. Mycobacteria differ from other bacteria in that they have a cell wall composed of specific surface glycans that are the major determinant of these organisms' path...