Cognitive Processing Speed in Older Adults: Relationship with White Matter Integrity

• Published in: PloS one Vol. 7; no. 11; p. e50425
• Main Authors: Kerchner, Geoffrey A., Racine, Caroline A., Hale, Sandra, Wilheim, Reva, Laluz, Victor, Miller, Bruce L., Kramer, Joel H.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.11.2012; Public Library of Science (PLoS)
• Subjects: Adults; Age; Aged; Aged, 80 and over; Aging; Anisotropy; Atrophy; Biology; Brain Mapping; Brain research; Choice Behavior; Cognition & reasoning; Cognition - physiology; Cognitive ability; Cognitive tasks; Corpus callosum; Corpus Callosum - anatomy & histology; Corpus Callosum - physiology; Cross-Sectional Studies; Dementia; Diffusion rate; Diffusion Tensor Imaging; Drug abuse; Female; Frontal Lobe - anatomy & histology; Frontal Lobe - physiology; Humans; Information processing; Integrity; Ischemia; Magnetic resonance imaging; Male; Mediation; Medicine; Memory; Middle Aged; Neurology; Neuropsychology; Older people; Parietal Lobe - anatomy & histology; Parietal Lobe - physiology; Perforant Pathway - anatomy & histology; Perforant Pathway - physiology; Reaction time; Reaction Time - physiology; Reaction time task; Skin cancer; Statistical analysis; Substantia alba; Task Performance and Analysis; United States > US; San Francisco California; California

Cognitive processing slows with age. We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time task...