Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro
Borna disease virus (BDV) is a neurotropic virus that produces neuropsychiatric dysfunction in a wide range of warm-blooded species. Several studies have associated BDV with human psychiatric illness, but the findings remain controversial. Although oligodendrocytes are a major glial component of bra...
Saved in:
Published in | PloS one Vol. 8; no. 6; p. e66623 |
---|---|
Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
21.06.2013
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Borna disease virus (BDV) is a neurotropic virus that produces neuropsychiatric dysfunction in a wide range of warm-blooded species. Several studies have associated BDV with human psychiatric illness, but the findings remain controversial. Although oligodendrocytes are a major glial component of brain white matter and play a pivotal role in neuronal cell function, BDV's effects on human oligodendrocytes have not been clarified. Here, the effects of two BDV strains, Hu-H1 (isolated from a bipolar patient) and Strain V (a laboratory strain), on the proliferation and apoptosis of human oligodendrocytes were investigated. Three experimental cell lines were constructed: Hu-H1-infected oligodendroglioma (Hu-H1) cells, Strain V-infected oligodendroglioma (Strain V) cells, and non-infected oligodendroglioma (control) cells. BDV infection was assayed by BDV nucleoprotein (p40) immunofluorescence, cell proliferation was assayed by Cell Counting Kit-8 (CCK8), and cell cycle phases and apoptosis were assayed by flow cytometry. Expressions of the apoptosis-related proteins Bax and Bcl-2 were measured by Western blotting. p40 expression was confirmed in Hu-H1 and Strain V on and after day three post-infection. Strain V cells showed significantly greater cellular proliferation than Hu-H1 cells on and after day three post-infection. In Hu-H1 cells, Bax and Bcl-2 expression were significantly increased and decreased, respectively, on and after day three post-infection. In contrast, in Strain V cells, Bax and Bcl-2 expression were significantly decreased and increased, respectively, on and after day three post-infection. In conclusion, Hu-H1 inhibits cellular proliferation and promotes apoptosis in human oligodendrocytes via Bax upregulation and Bcl-2 downregulation. In contrast, Strain V promotes cellular proliferation and inhibits apoptosis in human oligodendrocytes via Bax downregulation and Bcl-2 upregulation. The effects of the Hu-H1 strain (isolated from a bipolar patient) are opposite from those of Strain V (a laboratory strain), thereby providing a proof of authenticity for both. |
---|---|
AbstractList | Borna disease virus (BDV) is a neurotropic virus that produces neuropsychiatric dysfunction in a wide range of warm-blooded species. Several studies have associated BDV with human psychiatric illness, but the findings remain controversial. Although oligodendrocytes are a major glial component of brain white matter and play a pivotal role in neuronal cell function, BDV's effects on human oligodendrocytes have not been clarified. Here, the effects of two BDV strains, Hu-H1 (isolated from a bipolar patient) and Strain V (a laboratory strain), on the proliferation and apoptosis of human oligodendrocytes were investigated. Three experimental cell lines were constructed: Hu-H1-infected oligodendroglioma (Hu-H1) cells, Strain V-infected oligodendroglioma (Strain V) cells, and non-infected oligodendroglioma (control) cells. BDV infection was assayed by BDV nucleoprotein (p40) immunofluorescence, cell proliferation was assayed by Cell Counting Kit-8 (CCK8), and cell cycle phases and apoptosis were assayed by flow cytometry. Expressions of the apoptosis-related proteins Bax and Bcl-2 were measured by Western blotting. p40 expression was confirmed in Hu-H1 and Strain V on and after day three post-infection. Strain V cells showed significantly greater cellular proliferation than Hu-H1 cells on and after day three post-infection. In Hu-H1 cells, Bax and Bcl-2 expression were significantly increased and decreased, respectively, on and after day three post-infection. In contrast, in Strain V cells, Bax and Bcl-2 expression were significantly decreased and increased, respectively, on and after day three post-infection. In conclusion, Hu-H1 inhibits cellular proliferation and promotes apoptosis in human oligodendrocytes via Bax upregulation and Bcl-2 downregulation. In contrast, Strain V promotes cellular proliferation and inhibits apoptosis in human oligodendrocytes via Bax downregulation and Bcl-2 upregulation. The effects of the Hu-H1 strain (isolated from a bipolar patient) are opposite from those of Strain V (a laboratory strain), thereby providing a proof of authenticity for both. |
Audience | Academic |
Author | Li, Dan Huang, Rongzhong Li, Wenjuan Zhang, Liang Xie, Peng Deng, Jing Li, Juan Liu, Xia Cheng, Shigang Zhou, Chanjuan Ma, Lihua Lei, Yang Zhang, Hongzhi Wang, Xiao Zhang, Yong Huang, Hua |
AuthorAffiliation | 1 Department of Pathology, Faculty of Basic Medicine, Chongqing Medical University, Chongqing, China 2 Neuroscience Center, Key Laboratory of Neurobiology of Chongqing, Chongqing, China Massachusetts Eye & Ear Infirmary, Harvard Medical School, United States of America 3 Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China 4 Department of Neurology, The Chongqing Zhongshan Hospital, Chongqing, China |
AuthorAffiliation_xml | – name: 2 Neuroscience Center, Key Laboratory of Neurobiology of Chongqing, Chongqing, China – name: 4 Department of Neurology, The Chongqing Zhongshan Hospital, Chongqing, China – name: Massachusetts Eye & Ear Infirmary, Harvard Medical School, United States of America – name: 3 Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China – name: 1 Department of Pathology, Faculty of Basic Medicine, Chongqing Medical University, Chongqing, China |
Author_xml | – sequence: 1 givenname: Dan surname: Li fullname: Li, Dan organization: Department of Pathology, Faculty of Basic Medicine, Chongqing Medical University, Chongqing, China ; Neuroscience Center, Key Laboratory of Neurobiology of Chongqing, Chongqing, China – sequence: 2 givenname: Yang surname: Lei fullname: Lei, Yang – sequence: 3 givenname: Jing surname: Deng fullname: Deng, Jing – sequence: 4 givenname: Chanjuan surname: Zhou fullname: Zhou, Chanjuan – sequence: 5 givenname: Yong surname: Zhang fullname: Zhang, Yong – sequence: 6 givenname: Wenjuan surname: Li fullname: Li, Wenjuan – sequence: 7 givenname: Hua surname: Huang fullname: Huang, Hua – sequence: 8 givenname: Shigang surname: Cheng fullname: Cheng, Shigang – sequence: 9 givenname: Hongzhi surname: Zhang fullname: Zhang, Hongzhi – sequence: 10 givenname: Liang surname: Zhang fullname: Zhang, Liang – sequence: 11 givenname: Rongzhong surname: Huang fullname: Huang, Rongzhong – sequence: 12 givenname: Xia surname: Liu fullname: Liu, Xia – sequence: 13 givenname: Lihua surname: Ma fullname: Ma, Lihua – sequence: 14 givenname: Xiao surname: Wang fullname: Wang, Xiao – sequence: 15 givenname: Juan surname: Li fullname: Li, Juan – sequence: 16 givenname: Peng surname: Xie fullname: Xie, Peng |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23805250$$D View this record in MEDLINE/PubMed |
BookMark | eNqNk8uO0zAUhiM0iLnAGyCIhIRg0WLHiS-bkcpwmUoVRVxmazm207pK7WI7iEo8PA7NjBo0C5SF4-Pv_Pb57XOenVhndZY9hWAKEYFvNq7zVrTTXQpPAcAYF-hBdgYZKia4AOjk6P80Ow9hA0CFKMaPstMCUVAVFTjLfl93W2Hzuov5JxfzhaidF9H5ff7WJfn8nQlaBJ3fGN-FfG7XpjYx5J-9a02jE2qczYVVaUl1Uod8tnO76IIJubH5QXzZmpVT2irv5D7qXibpRe8eZw8b0Qb9ZBgvsu8f3n-7up4slh_nV7PFRGJWxIliDNZa6EoDQEuAQUNLylhFFGZUk6IuUVOCNKmqijEKi6apFIa4VjVCJUDoInt-0N21LvDBuMCTjQAl22hPzA-EcmLDd95shd9zJwz_G3B-xYWPRraaM8kUqxkpK8BKTYGABMkKN0xCQjWTSety2K2rt1pJbaMX7Uh0vGLNmq_cT44wZYQUSeDVIODdj06HyLcmSN22wmrXpXMTBklFIO7P_eIf9P7qBmolUgHGNi7tK3tRPisJhbQoAUnU9B4qfUpvjUyvrDEpPkp4PUpITNS_4kp0IfD51y__zy5vxuzLI3atRRvXwbVd_9bCGCwPoPQuBK-bO5Mh6OuHt27wvkn40CQp7dnxBd0l3XYF-gO2Sw2d |
CitedBy_id | crossref_primary_10_1016_j_gendis_2019_04_002 crossref_primary_10_1186_s12985_015_0239_y crossref_primary_10_3892_mmr_2015_3828 crossref_primary_10_1186_s40360_020_0391_x crossref_primary_10_3892_mmr_2016_5842 crossref_primary_10_3892_mmr_2017_8011 crossref_primary_10_3390_ijms25031849 crossref_primary_10_3390_pediatric15030047 crossref_primary_10_1016_j_virol_2015_06_024 crossref_primary_10_1186_1743_422X_11_161 crossref_primary_10_3390_cells12131767 crossref_primary_10_3390_ijms160819347 crossref_primary_10_3892_mmr_2016_5959 crossref_primary_10_1016_j_tvjl_2013_12_012 crossref_primary_10_1016_j_virol_2014_06_040 crossref_primary_10_3390_ijms17040435 crossref_primary_10_1080_22221751_2022_2065931 crossref_primary_10_1002_jmv_25951 crossref_primary_10_1039_C6MB00651E crossref_primary_10_1016_j_neuroscience_2014_03_009 crossref_primary_10_1007_s13277_014_2773_4 crossref_primary_10_1007_s12264_022_00906_w |
Cites_doi | 10.1002/jcla.20261 10.1128/JVI.02321-08 10.1186/1742-2094-5-16 10.1074/jbc.M005107200 10.2741/elder 10.2741/A789 10.1128/JVI.77.20.11186-11192.2003 10.1002/(SICI)1097-0320(19960601)24:2<131::AID-CYTO5>3.0.CO;2-M 10.1128/JVI.05663-11 10.1128/CMR.16.3.534-545.2003 10.1186/1742-2094-5-50 10.1016/0168-1702(96)01338-X 10.4049/jimmunol.178.8.5340 10.1128/JVI.00806-09 10.1128/JVI.02426-06 10.1016/j.micinf.2006.12.015 10.1128/JVI.75.18.8742-8751.2001 10.20506/rst.19.1.1217 10.1371/journal.pone.0044665 10.1128/JVI.02014-07 10.1111/j.1468-1331.2008.02516.x 10.1128/CMR.14.3.513-527.2001 10.4103/0255-0857.53200 10.1016/j.neuint.2011.02.020 10.4161/auto.6260 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2013 Public Library of Science 2013 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Li et al 2013 Li et al |
Copyright_xml | – notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2013 Li et al 2013 Li et al |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PIMPY PQEST PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
DOI | 10.1371/journal.pone.0066623 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Opposing Viewpoints (Gale) Gale in Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic Technology Collection Technology Research Database Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | Agricultural Science Database MEDLINE |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) Medicine Biology |
DocumentTitleAlternate | BDV Affect Proliferation and Apoptosis |
EISSN | 1932-6203 |
Editor | Vavvas, Demetrios |
Editor_xml | – sequence: 1 givenname: Demetrios surname: Vavvas fullname: Vavvas, Demetrios |
EndPage | e66623 |
ExternalDocumentID | 1370366283 oai_doaj_org_article_9c9d9b9745094e80a173c56f9c178e9c 3002027581 A478182407 10_1371_journal_pone_0066623 23805250 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- 123 29O 2WC 3V. 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV ADRAZ AEAQA AENEX AFKRA AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BBORY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CGR CS3 CUY CVF D1I D1J D1K DIK DU5 E3Z EAP EAS EBD ECM EIF EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ NPM O5R O5S OK1 P2P P62 PATMY PDBOC PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RIG RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM AAYXX AFPKN CITATION 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PQEST PQUKI PRINS RC3 7X8 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
ID | FETCH-LOGICAL-c692t-d991beae5e0084060f8489957d698e72b43f40d6955599812ff5d616bdb334033 |
IEDL.DBID | RPM |
ISSN | 1932-6203 |
IngestDate | Fri Nov 26 17:13:07 EST 2021 Tue Oct 22 15:15:14 EDT 2024 Tue Sep 17 21:29:08 EDT 2024 Fri Jun 28 17:29:13 EDT 2024 Thu Oct 10 19:06:13 EDT 2024 Fri Feb 23 00:05:38 EST 2024 Fri Feb 02 04:06:16 EST 2024 Thu Aug 01 19:13:17 EDT 2024 Thu Aug 01 20:37:01 EDT 2024 Tue Aug 20 22:09:26 EDT 2024 Fri Aug 23 01:31:14 EDT 2024 Wed Oct 16 00:39:54 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 |
Language | English |
License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c692t-d991beae5e0084060f8489957d698e72b43f40d6955599812ff5d616bdb334033 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: DL PX. Performed the experiments: JD YL WL HH SC HZ CZ. Analyzed the data: DL JD LZ RH XL PX. Contributed reagents/materials/analysis tools: DL JD LM XW. Wrote the paper: DL JD YZ JL. Competing Interests: The authors have declared that no competing interests exist. |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689772/ |
PMID | 23805250 |
PQID | 1370366283 |
PQPubID | 1436336 |
PageCount | e66623 |
ParticipantIDs | plos_journals_1370366283 doaj_primary_oai_doaj_org_article_9c9d9b9745094e80a173c56f9c178e9c pubmedcentral_primary_oai_pubmedcentral_nih_gov_3689772 proquest_miscellaneous_1791757163 proquest_journals_1370366283 gale_infotracmisc_A478182407 gale_infotracacademiconefile_A478182407 gale_incontextgauss_ISR_A478182407 gale_incontextgauss_IOV_A478182407 gale_healthsolutions_A478182407 crossref_primary_10_1371_journal_pone_0066623 pubmed_primary_23805250 |
PublicationCentury | 2000 |
PublicationDate | 2013-06-21 |
PublicationDateYYYYMMDD | 2013-06-21 |
PublicationDate_xml | – month: 06 year: 2013 text: 2013-06-21 day: 21 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
PublicationTitle | PloS one |
PublicationTitleAlternate | PLoS One |
PublicationYear | 2013 |
Publisher | Public Library of Science Public Library of Science (PLoS) |
Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
References | JF Zhao (ref26) 2011; 19 ref14 MV Ovanesov (ref23) 2008; 5 JD Gibbs (ref3) 2009; 83 KM Carbone (ref19) 2001; 14 RT Elder (ref1) 2002; 7 O Planz (ref27) 2003; 77 JC de la Torre (ref31) 1996; 44 L Bode (ref21) 2003; 16 RZ Huang (ref18) 2012; 7(9) M van Engeland (ref15) 1996; 24 BL Williams (ref8) 2008; 82 Y Watanabe (ref25) 2007; 9 H Ludwig (ref7) 2000; 19 L Bode (ref13) 1996; 1 C Fluur (ref2) 2007; 178 D Brnic (ref10) 2012; 86 SO Nunes (ref5) 2008; 22 MV Ovanesov (ref24) 2008; 5 A Hans (ref29) 2001; 276 S Das (ref9) 2011; 59 K Ikuta (ref20) 2002; 7d B Levine (ref30) 2008; 4 ref4 YJ Wu (ref12) 2013; 110 Q Li (ref16) 2009; 16 R Thakur (ref22) 2009; 27 ref6 W Kamitani (ref28) 2001; 75 M Poenisch (ref11) 2009; 83 R Clemente (ref17) 2007; 81 |
References_xml | – volume: 22 start-page: 314 year: 2008 ident: ref5 article-title: RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives publication-title: J Clin Lab Anal doi: 10.1002/jcla.20261 contributor: fullname: SO Nunes – volume: 83 start-page: 4297 year: 2009 ident: ref11 article-title: Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats publication-title: J Virol doi: 10.1128/JVI.02321-08 contributor: fullname: M Poenisch – volume: 5 start-page: 16 year: 2008 ident: ref23 article-title: Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus publication-title: J Neuroinflammation doi: 10.1186/1742-2094-5-16 contributor: fullname: MV Ovanesov – volume: 276 start-page: 7258 year: 2001 ident: ref29 article-title: Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells publication-title: J Biol Chem doi: 10.1074/jbc.M005107200 contributor: fullname: A Hans – volume: 7 start-page: 349 year: 2002 ident: ref1 article-title: HIV-1 VPR modulates cell cycle G2/M transition through an alternative cellular mechanism other than the classic mitotic checkpoints publication-title: Front Biosci doi: 10.2741/elder contributor: fullname: RT Elder – volume: 7d start-page: 470 year: 2002 ident: ref20 article-title: Borna disease virus and infection in humans publication-title: Front Biosci doi: 10.2741/A789 contributor: fullname: K Ikuta – volume: 77 start-page: 11186 year: 2003 ident: ref27 article-title: Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex publication-title: J Virol doi: 10.1128/JVI.77.20.11186-11192.2003 contributor: fullname: O Planz – volume: 24 start-page: 131 year: 1996 ident: ref15 article-title: A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture publication-title: Cytometry doi: 10.1002/(SICI)1097-0320(19960601)24:2<131::AID-CYTO5>3.0.CO;2-M contributor: fullname: M van Engeland – volume: 86 start-page: 2512 year: 2012 ident: ref10 article-title: Borna disease virus infects human neural progenitor cells and impairs neurogenesis publication-title: J Virol doi: 10.1128/JVI.05663-11 contributor: fullname: D Brnic – volume: 16 start-page: 534 year: 2003 ident: ref21 article-title: Borna disease virus infection, a human mental health risk publication-title: Clin Microbiol Rev doi: 10.1128/CMR.16.3.534-545.2003 contributor: fullname: L Bode – volume: 5 start-page: 50 year: 2008 ident: ref24 article-title: Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection publication-title: Neuroinflammation doi: 10.1186/1742-2094-5-50 contributor: fullname: MV Ovanesov – ident: ref4 – volume: 44 start-page: 33 year: 1996 ident: ref31 article-title: Sequence characterization of human Borna disease virus publication-title: Virus Res doi: 10.1016/0168-1702(96)01338-X contributor: fullname: JC de la Torre – ident: ref6 – volume: 110 start-page: 1899 year: 2013 ident: ref12 article-title: Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors. Proc Natl Acad Sci contributor: fullname: YJ Wu – volume: 178 start-page: 5340 year: 2007 ident: ref2 article-title: Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection publication-title: J Immunol doi: 10.4049/jimmunol.178.8.5340 contributor: fullname: C Fluur – volume: 83 start-page: 12424 year: 2009 ident: ref3 article-title: Cell Cycle Arrest by Transforming Growth Factor β1 Enhances Replication of Respiratory Syncytial Virus in Lung Epithelial Cells publication-title: J Virol doi: 10.1128/JVI.00806-09 contributor: fullname: JD Gibbs – volume: 81 start-page: 5968 year: 2007 ident: ref17 article-title: Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing of the virus surface glycoprotein publication-title: J Virol doi: 10.1128/JVI.02426-06 contributor: fullname: R Clemente – volume: 9 start-page: 417 year: 2007 ident: ref25 article-title: Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility publication-title: Microbes Infect doi: 10.1016/j.micinf.2006.12.015 contributor: fullname: Y Watanabe – volume: 19 start-page: 60 year: 2011 ident: ref26 article-title: Effects of ginkgo biloba extract on cell increasing cycle in astrocytes publication-title: Chinese Journal of Clinical Neuroscience contributor: fullname: JF Zhao – volume: 75 start-page: 8742 year: 2001 ident: ref28 article-title: Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1 publication-title: J Virol doi: 10.1128/JVI.75.18.8742-8751.2001 contributor: fullname: W Kamitani – volume: 19 start-page: 259 year: 2000 ident: ref7 article-title: Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology publication-title: Rev sci tech Off Int Epiz doi: 10.20506/rst.19.1.1217 contributor: fullname: H Ludwig – volume: 7(9) start-page: e44665 year: 2012 ident: ref18 article-title: Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells publication-title: PLoS One doi: 10.1371/journal.pone.0044665 contributor: fullname: RZ Huang – volume: 82 start-page: 1748 year: 2008 ident: ref8 article-title: Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection publication-title: J Virol doi: 10.1128/JVI.02014-07 contributor: fullname: BL Williams – volume: 16 start-page: 399 year: 2009 ident: ref16 article-title: Detection and analysis of Borna disease virus in Chinese patients with neurological disorders publication-title: Eur J Neurol doi: 10.1111/j.1468-1331.2008.02516.x contributor: fullname: Q Li – volume: 1 start-page: 200 year: 1996 ident: ref13 article-title: First isolates of infectious human Borna disease virus from patients with mood disorders. Mol publication-title: Psychiatr contributor: fullname: L Bode – volume: 14 start-page: 513 year: 2001 ident: ref19 article-title: Borna disease virus and human disease publication-title: Clin Microbiol doi: 10.1128/CMR.14.3.513-527.2001 contributor: fullname: KM Carbone – volume: 27 start-page: 191 year: 2009 ident: ref22 article-title: Role of Borna disease virus in neuropsychiatric illnesses: are we inching closer? publication-title: Indian J Med Microbiol doi: 10.4103/0255-0857.53200 contributor: fullname: R Thakur – volume: 59 start-page: 357 year: 2011 ident: ref9 article-title: Viral infection and neural stem/progenitor cell's fate: implications in brain development and neurological disorders publication-title: Neurochem Int doi: 10.1016/j.neuint.2011.02.020 contributor: fullname: S Das – ident: ref14 – volume: 4 start-page: 600 year: 2008 ident: ref30 article-title: Bcl-2 family members: dual regulators of apoptosis and autophagy publication-title: Autophagy doi: 10.4161/auto.6260 contributor: fullname: B Levine |
SSID | ssj0053866 |
Score | 2.256243 |
Snippet | Borna disease virus (BDV) is a neurotropic virus that produces neuropsychiatric dysfunction in a wide range of warm-blooded species. Several studies have... |
SourceID | plos doaj pubmedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | e66623 |
SubjectTerms | Apoptosis Assaying Autophagy Bax protein Bcl-2 protein bcl-2-Associated X Protein - biosynthesis Biology Bipolar Disorder - metabolism Bipolar Disorder - pathology Bipolar Disorder - virology Borna disease Borna Disease - metabolism Borna Disease - pathology Borna disease virus - metabolism Brain Cell cycle Cell Line Cell lines Cell Proliferation Cytometry Flow cytometry Health aspects Hospitals Humans Immunofluorescence Infections Kinases Laboratories Medical research Medicine Mental disorders Neurobiology Neurology Neurons Neurosciences Oligodendrocytes Oligodendroglia - metabolism Oligodendroglia - virology Oligodendroglioma Proteins Proto-Oncogene Proteins c-bcl-2 - biosynthesis Substantia alba Viruses Western blotting |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3BbtQwELXQnrggSoEGSjEICTiEOrFjJ8ctULUIWgS06i2KHYdGqpJokxwq8fHMxN5VgyrBgePGE2t35tl5sxm_IeSVkkUhmAHw6lSHoqxsmBplQsMSYzMhYjM1m_hyIo_OxKeL5OJGqy-sCXPywM5x-5nJykwD60WlN5uyIlLcJLLKTKRSm5lp942SdTLl9mBYxVL6g3JcRfs-Lu-6trFYySVlzGcPokmvf7MrL7qrtr-Ncv5ZOXnjUXR4n9zzHJIu3XffInds84Bs-VXa0zdeSvrtNvk1_UdP9TjQk3agn13E29U1PcDOxPSDez1Dz-vV2NPj5rLW9dDTr9jKp7IOHLRoSoodPnDuZdd2Q9vXPa0b6iY_vaoht7UofGCugbiCLcw3rNqH5Ozw44_3R6HvtxAamcVDWAJX1LawiUWVfSZZlQpIxxJVyiy1KtaCV4LBhwRlyoAZVFVSykjqUnMuGOePyKIBD-8QqgTESWY61qyABIdlKbbBspwDJShtyQMSrp2fd05WI5_erSlIR5wXcwxW7oMVkAOM0MYWRbGnCwCV3EMl_xtUAvIc45u7E6abpZ0v8bhtiqltQF5OFiiM0WDlzc9i7Pv8-PT8H4y-f5sZvfZGVQtIMYU_7QC_CQW3Zpa7M0tY3mY2vINoXHulRx8B65BAC-HONUJvH36xGcZJsZquse0INgqS9AQyZbB57AC98SxQOGxtyAKiZlCfuX4-0tSXky45lylkE_GT_xGrp-Ru7BqPhHG0SxbDarTPgP4Nem9a6b8B3ZdXCw priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Health Database dbid: 8C1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZguXBBlFdTChiEBBxCnTixkxPaFqoWQYuAVr1FseO0kao4JNlDJX48M4k3EFQhjruetbLzcGbs8fcR8lKKPI-YBudVifKjojR-oqX2NYu1SaMo1APZxOcjcXASfTyLz9yGW-faKtdr4rBQF1bjHvlOwBEqSsDb8F3zw0fWKDxddRQaN8mtABwTqRuSvanFA2JZCHddjstgx1nnbWNrg_1cMBufvY4G1P5pbV40l7a7LvH8u3_yjxfS_l1yx2WSdDmafoPcMPU9suFitaOvHaD0m_vk57BTT9Wqp0e2p59Gu9v2iu4iPzF9Px7S0NOqXXX0sL6oVNV39AsS-pRmdBGa1wVFng-ce9nYprdd1dGqpuPkx5cVVLgG4Q_0FaSvIAvz9a19QE72P3zfO_Ad64KvRRr2fgEZozK5iQ1i7TPByiSCoiyWhUgTI0MV8TJi8CFGsDLID8oyLkQgVKE4jxjnD8miBg1vEiqjPJAiVaFiOZQ5LE2QDMtwDolBYQruEX-t_KwZwTWy4YRNQlEyajFDY2XOWB7ZRQtNsgiNPXxh2_PMRVqW6rRIFZRJCA1oEgaPwHUsylQHMjGp9sgztG823jOdAjxb4qXbBAtcj7wYJBAeo8b-m_N81XXZ4fHpfwh9-zoTeuWESgueonN35wH-E8JuzSS3Z5IQ5Ho2vIneuNZKl_0OB_jl2kOvH34-DeOk2FNXG7sCGQmlegz1Msg8Gh160iwkckhwyDwiZ64-U_18pK4uBnRyLhKoKcKtfz_WY3I7HIlF_DDYJou-XZknkN716ukQw78AmLZOrQ priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Nb9QwELXKcuGCKF_dUsAgJOCQyhs7dnJAaAtULaItArbqLYodp420StJ8SF2JH89Mko0IWqQes55Y2fFM_Ca23yPkjZJRJJiB4NW-dkScWMc3yjiGecYGQrimFZs4OZVHC_H1wrvYImvN1t6B1cbSDvWkFuVy_-Z69RES_kOr2qBm65v2izyzuE9LwpR-h9x1BRcY8ydiWFeA7G5XLxG1ONJlvD9M979eRpNVy-k_vLknxTKvNsHSf3dX_jVdHT4g93ucSeddYGyTLZs9JNt9Jlf0XU83_f4R-d1-x6e6qelpXtNvXVTk5YoeoHox_dwt4dDztGwqepxdpTqtK_od5X4S2wUQjbKYogoI9j0v8qLOq7SiaUa7zs-WKdS_FskRzArALdhCf3WZPyaLwy-_Ph05vSaDY2Tg1k4MeFLbyHoWmfiZZIkvoGTzVCwD3ypXC54IBhceUpkBekgSL5YzqWPNuWCcPyGTDDy8Q6gS0UzJQLuaRVAEscBHqSzLOcCG2MZ8Spy188Oio94I2_U3BSVL58UQByvsB2tKDnCEBlskzm5_yMvLsM_DMDBBHGgoopA40PoMHoEbTyaBmSnfBmZKXuL4ht0p1CH9wzkeyfWx_J2S160FkmdkuDvnMmqqKjw-O7-F0c8fI6O3vVGSQ6SYqD8RAf8JSblGlnsjS3gFmFHzDkbj2isV-giQiQToCHeuI3Rz86uhGTvFHXeZzRuwUVDIe1BNg83TLqAHzwLMQ_lDNiVqFOoj149bsvSq5S7n0oeKw929jX-ekXtuJz7iuLM9MqnLxj4HCFjrF21W_wHLh1in priority: 102 providerName: Scholars Portal |
Title | Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro |
URI | https://www.ncbi.nlm.nih.gov/pubmed/23805250 https://www.proquest.com/docview/1370366283 https://search.proquest.com/docview/1791757163 https://pubmed.ncbi.nlm.nih.gov/PMC3689772 https://doaj.org/article/9c9d9b9745094e80a173c56f9c178e9c http://dx.doi.org/10.1371/journal.pone.0066623 |
Volume | 8 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe2IhAviBXYCqMYhAQ8pE3ixE4e27KxIdpVg019i2LH2SJ1SdWkD5X447nLR7WgPSBeLCW-WInvzr6L735HyEfBw9AxFQiv9KThRLE2PCWUoUxXad9xbFUWm5jO-NmV833hLvaI2-TClEH7SiaDdHk3SJPbMrZydaeGTZzYcD6dMO6B2WIP98m-YKxx0avlFxSY8zpHjglrWLNksMpSjUFcHPZ7RABmiOWP2fb3tqMStX-3NndWyyx_yPD8O37y3oZ0-pw8qy1JOqre-IDs6bRLHle1Jbdd8mRan5p3yUGtwDn9XKNMf3lBfpe_76ncFHSWFfRHJQzZekvHWLSYfq1Obuh1st7k9Dy9TWRS5HSOVX5iXckNDdOIYvEPHHu0ylZFlic5TVJaDX6xTMDt1YiJoLZg0wItjFess5fk6vTk1-TMqEsxGIr7dmFEYEZKHWpXIwC_yc3Yc8BTc0XEfU8LWzosdky4cBHBDIyGOHYjbnEZScYck7FXpJMCB44IFU5oCe5LW5oh-D6m72GFLM0YWAuRjliPGA1HglWFuBGUx24CPJVqagNkZlAzs0fGyLYdLeJllzey9U1QS03gKz_yJfhOiBeoPRNegSmXx76yhKd91SPvkOlBlXy60_pghJm4Hnq9PfKhpEDMjBSDcm7CTZ4H5xfX_0D087JF9KkmijMQHxXWiRDwTYjF1aI8blGC5qtW9xGKaDMrOc4RGCQcLEZ4shHbh7vf77pxUAy0S3W2ARoB_rsLTjTQHFZSvpvZRmd6RLTkvzX17R7Q4BKyvNbY1__95Bvy1K4KkRi2dUw6xXqj34I5WMg-LAILAa03sbA9_dYnj8Yns_llv_zBAu3U8frlIvEHE7dkHg |
link.rule.ids | 230,315,733,786,790,870,891,2115,2236,12083,12250,12792,21416,24346,27955,27956,31752,31753,33299,33300,33406,33407,33777,33778,43343,43612,43633,43838,53825,53827,74100,74369,74390,74657 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELege4AXtPG1wmAGIQEPYUmc2MkTamFTC103jW3amxU7zhZpSrImfZjEH89d4haCJsRj4uspvQ_7zj7_jpB3gidJ4GowXhUpJ0gz40RaaEe7oTZxEPi6bTZxOOeTs-DbRXhhN9xqW1a5mhPbiTotNe6R73kMoaI4rIafqxsHu0bh6aptoXGfbCDkZjQgG-P9-fHJai4Gb-bcXphjwtuz-vlUlYXBii7gx3oLUovbv56dB9V1Wd8Vev5dQfnHknSwSR7ZWJKOOuVvkXumeEy2rLfW9IOFlP74hPxs9-qpWjZ0XjZ01mm-XNzSMXYopl-7Yxp6ni-WNZ0WV7nKm5oeY0ufzHRGQpMipdjpA3mPqrJqyjqvaV7QjvnRdQ45rkEABH0LASzQAr9mUT4lZwf7p18mju274Gge-42TQsyoTGJCg2j7LnezKIC0LBQpjyMjfBWwLHDhIUS4MogQsixMucdVqhgLXMaekUEBEt4mVASJJ3isfOUmkOi4cYTtsAxjEBqkJmVD4qyEL6sOXkO2Z2wC0pJOihKVJa2yhmSMGlrTIjh2-6JcXErrazLWcRorSJQQHNBELnwC0yHPYu2JyMR6SHZRv7K7abp2cTnCa7cRprhD8ralQICMAitwLpNlXcvp0fl_EP046RG9t0RZCZaiE3vrAf4TAm_1KHd6lODmuje8jda4kkotfzsE_HJloXcPv1kPI1OsqitMuQQaAcl6CBkz0DzvDHotWQjlsMWhOySiZ-o90fdHivyqxSdnPIKswn_x78_aJQ8mp4czOZvOv78kD_2uzYjjeztk0CyW5hUEe416bT36F6mZU0E |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELagSIgXtPFrZYMZhAQ8ZE3ixE6eULdRrTC6Cdi0Nyt2nC3SlIQmfZjEH89d4gaCJsRj66uV3n1n38Xn7wh5I3iSBK4G8KpIOUGaGSfSQjvaDbWJg8DXbbOJLwt-dBZ8uggvbP1Tbcsq12tiu1CnpcZ35BOPIVUUh91wktmyiNPD2Yfqh4MdpPCk1bbTuEvuwa7IEeHRQV_uAX7Nub06x4Q3sZbaq8rCYG0XzMwGW1PL4N-v06PquqxvC0L_rqX8Y3OabZCHNqqk0w4Gm-SOKR6RTeu3NX1nyaXfPyY_27f2VK0auigbetxhoFze0H3sVUwPuwMbep4vVzWdF1e5ypuanmJzn8x0cKFJkVLs-YFzT6uyaso6r2le0G7yk-scsl2DVAj6BkJZkIX5mmX5hJzNPn4_OHJsBwZH89hvnBSiR2USExrk3Xe5m0UBJGihSHkcGeGrgGWBCx9CJC6DWCHLwpR7XKWKscBl7CkZFaDhLUJFkHiCx8pXbgIpjxtH2BjLMAZBQmpSNibOWvmy6og2ZHvaJiBB6bQo0VjSGmtM9tFCvSzSZLdflMtLab1OxjpOYwUpE9IEmsiFR2A65FmsPRGZWI_JLtpXdndOe2eXU7yAG2GyOyavWwmkyigQdJfJqq7l_OT8P4S-fR0IvbVCWQlI0Ym9_wD_CSm4BpI7A0lweD0Y3kI0rrVSy9-uAb9cI_T24Vf9ME6K9XWFKVcgIyBtDyF3BplnHaB7zUJQh80O3TERA6gPVD8cKfKrlqmc8QjyC__5vx9rl9wHV5bH88XnbfLA7_qNOL63Q0bNcmVeQNTXqJetO_8CtxlV2w |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Human+but+Not+Laboratory+Borna+Disease+Virus+Inhibits+Proliferation+and+Induces+Apoptosis+in+Human+Oligodendrocytes+In+Vitro&rft.jtitle=PloS+one&rft.au=Li%2C+Dan&rft.au=Lei%2C+Yang&rft.au=Deng%2C+Jing&rft.au=Zhou%2C+Chanjuan&rft.date=2013-06-21&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=8&rft.issue=6&rft.spage=e66623&rft_id=info:doi/10.1371%2Fjournal.pone.0066623&rft.externalDBID=ISR&rft.externalDocID=A478182407 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |