Systemic metabolite profiling reveals sexual dimorphism of AIBP control of metabolism in mice

• Published in: PloS one Vol. 16; no. 4; p. e0248964
• Main Authors: Kim, Jun-dae, Zhu, Lingping, Sun, Quan, Fang, Longhou
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Bile; Bile acids; Binding proteins; Biology and Life Sciences; Biosynthesis; Cholesterol; Cholesterol - metabolism; Dimorphism (Biology); Editing; Engineering and Technology; Fatty acids; Female; Females; Geriatrics; Glyceraldehyde-3-phosphate dehydrogenase; Health aspects; High density lipoprotein; Homeostasis; Lipid Metabolism; Lipids; Localization; Low density lipoprotein; Male; Medical research; Medicine; Medicine and Health Sciences; Metabolic disorders; Metabolism; Metabolites; Metabolome; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD; NAD - metabolism; Phosphoproteins - metabolism; Physiological aspects; Plasma; Polyunsaturated fatty acids; Principal components analysis; Racemases and Epimerases - metabolism; Regeneration; Research and Analysis Methods; Rodents; Sex differences; Sex Factors; Sexual dimorphism; Sterols; Tocopherol; Vitamin E; Vitamins; United States; United States > US; China

Emerging studies indicate that APOA-I binding protein (AIBP) is a secreted protein and functions extracellularly to promote cellular cholesterol efflux, thereby disrupting lipid rafts on the plasma membrane. AIBP is also present in the mitochondria and acts as an epimerase, facilitating the repair o...