Increased functional connectivity between limbic brain areas in healthy individuals with high versus low sensitivity to cold pain: A resting state fMRI study
The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affecti...
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| Published in | PloS one Vol. 17; no. 4; p. e0267170 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Public Library of Science
20.04.2022
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| Abstract | The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affective aspects of pain in two groups of healthy subjects with low versus high sensitivity to pain (LSP vs. HSP). We hypothesized that HSP will show stronger connectivity in brain regions involved in the affective-motivational processing of pain and that this higher connectivity would be related to negative affective and cognitive evaluations of pain.
Forty-eight healthy subjects were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (N = 24) reached the cut-off time of 180±0 sec and group HSP tolerated the CPT for an average of 13±4.8 sec. Heat, cold and mechanical evoked pain were measured, as well as pain-catastrophizing (PCS), depression, anxiety and stress (DASS-21). All subjects underwent resting state fMRI. ROI-to-ROI analysis was performed.
In comparison to the LSP, the HSP had stronger interhemispheric connectivity of the amygdala (p = 0.01) and between the amygdala and nucleus accumbens (NAc) (p = 0.01). Amygdala connectivity was associated with higher pain catastrophizing in the HSP only (p<0.01).
These findings suggest that high sensitivity to pain may be reflected by neural circuits involved in affective and motivational aspects of pain. To what extent this connectivity within limbic brain structures relates to higher alertness and more profound withdrawal behavior to aversive events needs to be further investigated. |
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| AbstractList | Background The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affective aspects of pain in two groups of healthy subjects with low versus high sensitivity to pain (LSP vs. HSP). We hypothesized that HSP will show stronger connectivity in brain regions involved in the affective-motivational processing of pain and that this higher connectivity would be related to negative affective and cognitive evaluations of pain. Methods Forty-eight healthy subjects were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (N = 24) reached the cut-off time of 180±0 sec and group HSP tolerated the CPT for an average of 13±4.8 sec. Heat, cold and mechanical evoked pain were measured, as well as pain-catastrophizing (PCS), depression, anxiety and stress (DASS-21). All subjects underwent resting state fMRI. ROI-to-ROI analysis was performed. Results In comparison to the LSP, the HSP had stronger interhemispheric connectivity of the amygdala (p = 0.01) and between the amygdala and nucleus accumbens (NAc) (p = 0.01). Amygdala connectivity was associated with higher pain catastrophizing in the HSP only (p<0.01). Conclusions These findings suggest that high sensitivity to pain may be reflected by neural circuits involved in affective and motivational aspects of pain. To what extent this connectivity within limbic brain structures relates to higher alertness and more profound withdrawal behavior to aversive events needs to be further investigated. Background The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affective aspects of pain in two groups of healthy subjects with low versus high sensitivity to pain (LSP vs. HSP). We hypothesized that HSP will show stronger connectivity in brain regions involved in the affective-motivational processing of pain and that this higher connectivity would be related to negative affective and cognitive evaluations of pain. Methods Forty-eight healthy subjects were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (N = 24) reached the cut-off time of 180±0 sec and group HSP tolerated the CPT for an average of 13±4.8 sec. Heat, cold and mechanical evoked pain were measured, as well as pain-catastrophizing (PCS), depression, anxiety and stress (DASS-21). All subjects underwent resting state fMRI. ROI-to-ROI analysis was performed. Results In comparison to the LSP, the HSP had stronger interhemispheric connectivity of the amygdala (p = 0.01) and between the amygdala and nucleus accumbens (NAc) (p = 0.01). Amygdala connectivity was associated with higher pain catastrophizing in the HSP only (p<0.01). Conclusions These findings suggest that high sensitivity to pain may be reflected by neural circuits involved in affective and motivational aspects of pain. To what extent this connectivity within limbic brain structures relates to higher alertness and more profound withdrawal behavior to aversive events needs to be further investigated. The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affective aspects of pain in two groups of healthy subjects with low versus high sensitivity to pain (LSP vs. HSP). We hypothesized that HSP will show stronger connectivity in brain regions involved in the affective-motivational processing of pain and that this higher connectivity would be related to negative affective and cognitive evaluations of pain. Forty-eight healthy subjects were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (N = 24) reached the cut-off time of 180±0 sec and group HSP tolerated the CPT for an average of 13±4.8 sec. Heat, cold and mechanical evoked pain were measured, as well as pain-catastrophizing (PCS), depression, anxiety and stress (DASS-21). All subjects underwent resting state fMRI. ROI-to-ROI analysis was performed. In comparison to the LSP, the HSP had stronger interhemispheric connectivity of the amygdala (p = 0.01) and between the amygdala and nucleus accumbens (NAc) (p = 0.01). Amygdala connectivity was associated with higher pain catastrophizing in the HSP only (p<0.01). These findings suggest that high sensitivity to pain may be reflected by neural circuits involved in affective and motivational aspects of pain. To what extent this connectivity within limbic brain structures relates to higher alertness and more profound withdrawal behavior to aversive events needs to be further investigated. The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affective aspects of pain in two groups of healthy subjects with low versus high sensitivity to pain (LSP vs. HSP). We hypothesized that HSP will show stronger connectivity in brain regions involved in the affective-motivational processing of pain and that this higher connectivity would be related to negative affective and cognitive evaluations of pain. Forty-eight healthy subjects were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (N = 24) reached the cut-off time of 180±0 sec and group HSP tolerated the CPT for an average of 13±4.8 sec. Heat, cold and mechanical evoked pain were measured, as well as pain-catastrophizing (PCS), depression, anxiety and stress (DASS-21). All subjects underwent resting state fMRI. ROI-to-ROI analysis was performed. In comparison to the LSP, the HSP had stronger interhemispheric connectivity of the amygdala (p = 0.01) and between the amygdala and nucleus accumbens (NAc) (p = 0.01). Amygdala connectivity was associated with higher pain catastrophizing in the HSP only (p<0.01). These findings suggest that high sensitivity to pain may be reflected by neural circuits involved in affective and motivational aspects of pain. To what extent this connectivity within limbic brain structures relates to higher alertness and more profound withdrawal behavior to aversive events needs to be further investigated. The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affective aspects of pain in two groups of healthy subjects with low versus high sensitivity to pain (LSP vs. HSP). We hypothesized that HSP will show stronger connectivity in brain regions involved in the affective-motivational processing of pain and that this higher connectivity would be related to negative affective and cognitive evaluations of pain.BACKGROUNDThe representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation. This study assessed differences in resting-state functional connectivity (rsFC) and its association to cognitive-affective aspects of pain in two groups of healthy subjects with low versus high sensitivity to pain (LSP vs. HSP). We hypothesized that HSP will show stronger connectivity in brain regions involved in the affective-motivational processing of pain and that this higher connectivity would be related to negative affective and cognitive evaluations of pain.Forty-eight healthy subjects were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (N = 24) reached the cut-off time of 180±0 sec and group HSP tolerated the CPT for an average of 13±4.8 sec. Heat, cold and mechanical evoked pain were measured, as well as pain-catastrophizing (PCS), depression, anxiety and stress (DASS-21). All subjects underwent resting state fMRI. ROI-to-ROI analysis was performed.METHODSForty-eight healthy subjects were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (N = 24) reached the cut-off time of 180±0 sec and group HSP tolerated the CPT for an average of 13±4.8 sec. Heat, cold and mechanical evoked pain were measured, as well as pain-catastrophizing (PCS), depression, anxiety and stress (DASS-21). All subjects underwent resting state fMRI. ROI-to-ROI analysis was performed.In comparison to the LSP, the HSP had stronger interhemispheric connectivity of the amygdala (p = 0.01) and between the amygdala and nucleus accumbens (NAc) (p = 0.01). Amygdala connectivity was associated with higher pain catastrophizing in the HSP only (p<0.01).RESULTSIn comparison to the LSP, the HSP had stronger interhemispheric connectivity of the amygdala (p = 0.01) and between the amygdala and nucleus accumbens (NAc) (p = 0.01). Amygdala connectivity was associated with higher pain catastrophizing in the HSP only (p<0.01).These findings suggest that high sensitivity to pain may be reflected by neural circuits involved in affective and motivational aspects of pain. To what extent this connectivity within limbic brain structures relates to higher alertness and more profound withdrawal behavior to aversive events needs to be further investigated.CONCLUSIONSThese findings suggest that high sensitivity to pain may be reflected by neural circuits involved in affective and motivational aspects of pain. To what extent this connectivity within limbic brain structures relates to higher alertness and more profound withdrawal behavior to aversive events needs to be further investigated. |
| Audience | Academic |
| Author | Pud, Dorit Eisenberg, Elon Löffler, Martin Grouper, Hadas Flor, Herta |
| AuthorAffiliation | 3 The Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, Israel 2 Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany 4 Institute of Pain Medicine, Haifa, Israel BG-Universitatsklinikum Bergmannsheil, Ruhr-Universitat Bochum, GERMANY 1 Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35442971$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1111_psyp_14680 crossref_primary_10_3390_biology12020211 crossref_primary_10_1176_appi_neuropsych_20240053 crossref_primary_10_1016_j_xcrm_2024_101784 crossref_primary_10_21769_BioProtoc_4794 |
| Cites_doi | 10.1177/1073858403261077 10.1016/0304-3959(89)90126-7 10.1054/jpai.2001.21597 10.1007/978-3-662-46450-2_13 10.1097/PR9.0000000000000694 10.3389/fnins.2013.00046 10.1016/j.pain.2013.05.040 10.1016/j.neulet.2005.01.037 10.1093/cercor/bhz298 10.1089/brain.2016.0440 10.1016/j.pneurobio.2008.09.018 10.4103/1673-5374.266909 10.1016/S0304-3959(02)00157-4 10.1089/brain.2012.0073 10.1016/S1090-3801(02)00058-7 10.1016/0005-7967(83)90009-8 10.3174/ajnr.A4655 10.1016/j.ejpain.2009.10.005 10.1016/j.neuroimage.2008.04.240 10.1038/sj.mp.4000812 10.1016/j.neuroimage.2020.117164 10.1002/hbm.22199 10.1097/j.pain.0000000000000494 10.1097/00002508-200103000-00008 10.1016/j.neuroimage.2008.10.024 10.1016/j.neucli.2007.07.002 10.1016/j.neuron.2007.08.004 10.1111/ejn.13125 10.1097/YCO.0b013e3283503510 10.1007/s12035-018-1130-9 10.1371/journal.pone.0221023 10.2522/ptj.20140352 10.1093/cercor/bhn256 10.1023/A:1025048802629 10.1016/j.neuron.2008.07.004 10.1016/j.ejpain.2004.11.001 10.1097/WNR.0000000000001208 10.1038/nn.3153 10.1523/JNEUROSCI.1315-04.2004 10.1002/ejp.1510 10.1038/nn.3811 10.1093/brain/awf137 10.1093/brain/aww100 10.1016/0893-133X(95)00205-R 10.1038/nrn1535 10.1186/s13041-015-0108-z 10.1162/jocn_a_00125 10.1016/j.neulet.2018.11.037 10.1016/j.neuroimage.2004.08.016 10.1155/2002/426193 10.1038/s41467-019-13785-z 10.1016/S1090-3801(03)00065-X 10.1073/pnas.0906186106 10.1016/j.conb.2008.09.012 10.1093/cercor/bhw157 10.1186/2049-9256-1-9 10.1523/JNEUROSCI.5282-03.2004 10.1097/j.pain.0000000000000720 10.1348/014466505X29657 10.1016/j.neuroimage.2013.02.028 10.1097/01.ajp.0000135236.12705.2d 10.1097/j.pain.0000000000000606 10.1002/hbm.21416 10.1016/S0005-7894(05)80306-5 10.1093/brain/awt211 10.1111/papr.12142 10.1016/j.pain.2014.05.018 10.1007/s00213-006-0510-4 |
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| References | T Rebbeck (pone.0267170.ref034) 2015; 95 V Neugebauer (pone.0267170.ref047) 2004; 10 JY Xie (pone.0267170.ref056) 2014; 155 M Granot (pone.0267170.ref018) 2005; 21 J. LeDoux (pone.0267170.ref042) 2003; 23 SM Nicola (pone.0267170.ref058) 2007; 191 IA Yun (pone.0267170.ref055) 2004; 24 F Nees (pone.0267170.ref063) 2017; 158 ACN Chen (pone.0267170.ref012) 1989; 37 CS Cleeland (pone.0267170.ref013) 1996; 15 RC Lapate (pone.0267170.ref051) 2012; 24 F Ambroggi (pone.0267170.ref057) 2008; 59 Y Tu (pone.0267170.ref005) 2019; 202 J Lethem (pone.0267170.ref044) 1983; 21 J Koenig (pone.0267170.ref075) 2014; 14 JY Kim (pone.0267170.ref022) 2013; 154 Z Shehzad (pone.0267170.ref076) 2009; 19 LE Simons (pone.0267170.ref036) 2014; 35 BJ Liddell (pone.0267170.ref050) 2005; 24 JC Motzkin (pone.0267170.ref067) 2021 E Navratilova (pone.0267170.ref052) 2014; 17 D Pud (pone.0267170.ref020) 2004; 8 E Vachon-Presseau (pone.0267170.ref033) 2016; 139 K Wiech (pone.0267170.ref062) 2013; 7 T Spisak (pone.0267170.ref004) 2020; 11 R Polianskis (pone.0267170.ref015) 2002; 6 JD Henry (pone.0267170.ref019) 2005; 44 AV Apkarian (pone.0267170.ref025) 2005; 9 R Treister (pone.0267170.ref010) 2010; 14 L Fan (pone.0267170.ref029) 2016; 26 MN Baliki (pone.0267170.ref032) 2012; 15 SD Mayhew (pone.0267170.ref002) 2013; 75 U Bingel (pone.0267170.ref028) 2002; 99 D Pud (pone.0267170.ref011) 2005; 380 AV Apkarian (pone.0267170.ref061) 2008; 18 M Löffler (pone.0267170.ref071) 2018; 3 JCW Brooks (pone.0267170.ref074) 2013; 7 N Egorova (pone.0267170.ref065) 2020; 24 AV Apkarian (pone.0267170.ref060) 2009; 87 D Clewett (pone.0267170.ref008) 2013; 13 WY Ong (pone.0267170.ref068) 2018; 56 LE Carter (pone.0267170.ref073) 2002; 7 V Sankarasubramanian (pone.0267170.ref006) 2017; 7 S Maren (pone.0267170.ref053) 2004; 5 V Salomons T (pone.0267170.ref070) 2004; 24 EG Duerden (pone.0267170.ref027) 2013; 34 D Szucs (pone.0267170.ref023) 2020; 221 R Peyron (pone.0267170.ref039) 2007; 37 M Sato (pone.0267170.ref045) 2015; 8 AMW Taylor (pone.0267170.ref016) 2016; 157 CM Lacadie (pone.0267170.ref030) 2008; 42 R Qi (pone.0267170.ref040) 2016; 37 H. Flor (pone.0267170.ref043) 2012; 25 G Galli (pone.0267170.ref001) 2016; 43 JA Hasmi (pone.0267170.ref064) 2013; 136 ME Geisser (pone.0267170.ref014) 1992; 23 HL Fields (pone.0267170.ref059) 2006 N Wanke (pone.0267170.ref069) 2020; 30 M Ploner (pone.0267170.ref003) 2010; 107 MA Belova (pone.0267170.ref054) 2007; 55 P Veinante (pone.0267170.ref048) 2013; 1 MJL Sullivan (pone.0267170.ref017) 2001; 17 Z Shen (pone.0267170.ref041) 2019; 30 HN Harris (pone.0267170.ref066) 2020; 15 N Ihara (pone.0267170.ref021) 2019; 14 HN Allen (pone.0267170.ref035) 2020 Y Jiang (pone.0267170.ref007) 2016; 157 CW Woo (pone.0267170.ref026) 2017; 8 M Davis (pone.0267170.ref049) 2001; 6 H Logan (pone.0267170.ref072) 2001; 2 V. Neugebauer (pone.0267170.ref046) 2015; 227 S Whitfield-Gabrieli (pone.0267170.ref024) 2012; 2 K Bornhövd (pone.0267170.ref038) 2002; 125 D Pud (pone.0267170.ref009) 2014 JM Thompson (pone.0267170.ref031) 2019; 702 AA Dubé (pone.0267170.ref037) 2009; 45 |
| References_xml | – volume: 10 start-page: 221 issue: 3 year: 2004 ident: pone.0267170.ref047 article-title: The Amygdala and Persistent Pain. publication-title: Neuroscientist doi: 10.1177/1073858403261077 – volume: 37 start-page: 143 issue: 2 year: 1989 ident: pone.0267170.ref012 article-title: Human pain responsivity in a tonic pain model: Psychological determinants publication-title: Pain doi: 10.1016/0304-3959(89)90126-7 – volume: 2 start-page: 160 issue: 3 year: 2001 ident: pone.0267170.ref072 article-title: Effects of stress and relaxation on capsaicin-induced pain publication-title: J Pain doi: 10.1054/jpai.2001.21597 – volume: 8 year: 2017 ident: pone.0267170.ref026 article-title: Quantifying cerebral contributions to pain beyond nociception publication-title: Nat Commun – volume: 227 start-page: 261 year: 2015 ident: pone.0267170.ref046 article-title: Amygdala pain mechanisms HHS Public Access. publication-title: Handb Exp Pharmacol doi: 10.1007/978-3-662-46450-2_13 – volume: 3 issue: 6 year: 2018 ident: pone.0267170.ref071 article-title: Impact of controllability on pain and suffering publication-title: Pain Reports doi: 10.1097/PR9.0000000000000694 – volume: 7 start-page: 1 year: 2013 ident: pone.0267170.ref062 article-title: Pain, decisions, and actions: A motivational perspective. publication-title: Front Neurosci. doi: 10.3389/fnins.2013.00046 – volume: 154 start-page: 1792 issue: 9 year: 2013 ident: pone.0267170.ref022 article-title: Increased power spectral density in resting-state pain-related brain networks in fibromyalgia publication-title: Pain doi: 10.1016/j.pain.2013.05.040 – volume: 380 start-page: 209 issue: 3 year: 2005 ident: pone.0267170.ref011 article-title: Homotopic and heterotopic effects of endogenous analgesia in healthy volunteers publication-title: Neurosci Lett doi: 10.1016/j.neulet.2005.01.037 – volume: 30 start-page: 3116 issue: 5 year: 2020 ident: pone.0267170.ref069 article-title: Subjective Uncontrollability over Aversive Events Reduces Working Memory Performance and Related Large-Scale Network Interactions publication-title: Cereb Cortex doi: 10.1093/cercor/bhz298 – volume: 7 issue: 3 year: 2017 ident: pone.0267170.ref006 article-title: Transcranial Direct Current Stimulation Targeting Primary Motor Versus Dorsolateral Prefrontal Cortices: Proof-of-Concept Study Investigating Functional Connectivity of Thalamocortical Networks Specific to Sensory-Affective Information Processing publication-title: BRAIN Connect doi: 10.1089/brain.2016.0440 – start-page: 101891 year: 2020 ident: pone.0267170.ref035 article-title: Left and right hemispheric lateralization of the amygdala in pain publication-title: Prog Neurobiol – volume: 87 start-page: 81 year: 2009 ident: pone.0267170.ref060 article-title: Towards a theory of chronic pain publication-title: Progress in neurobiology doi: 10.1016/j.pneurobio.2008.09.018 – volume: 15 start-page: 597 issue: 4 year: 2020 ident: pone.0267170.ref066 article-title: Evidence and explanation for the involvement of the nucleus accumbens in pain processing publication-title: Neural Regen Res doi: 10.4103/1673-5374.266909 – volume: 99 start-page: 313 issue: 1–2 year: 2002 ident: pone.0267170.ref028 article-title: Subcortical structures involved in pain processing: Evidence from single-trial fMRI publication-title: Pain doi: 10.1016/S0304-3959(02)00157-4 – volume: 2 start-page: 125 issue: 3 year: 2012 ident: pone.0267170.ref024 article-title: Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks. publication-title: Brain Connect doi: 10.1089/brain.2012.0073 – volume: 6 start-page: 475 issue: 6 year: 2002 ident: pone.0267170.ref015 article-title: Modality-specific facilitation and adaptation to painful tonic stimulation in humans publication-title: Eur J Pain doi: 10.1016/S1090-3801(02)00058-7 – volume: 13 start-page: 501 issue: 3 year: 2013 ident: pone.0267170.ref008 article-title: Amygdala functional connectivity is reduced after the cold pressor task. publication-title: Replicat Reliab – volume: 21 start-page: 401 issue: 4 year: 1983 ident: pone.0267170.ref044 article-title: Outline of a fear-avoidance model of exaggerated pain perception-I publication-title: Behav Res Ther doi: 10.1016/0005-7967(83)90009-8 – volume: 37 start-page: 1139 issue: 6 year: 2016 ident: pone.0267170.ref040 article-title: Abnormal amygdala resting-state functional connectivity in irritable bowel syndrome. publication-title: Am J Neuroradiol doi: 10.3174/ajnr.A4655 – volume: 14 start-page: 608 issue: 6 year: 2010 ident: pone.0267170.ref010 article-title: Factors affecting–And relationships between–Different modes of endogenous pain modulation in healthy volunteers publication-title: Eur J Pain doi: 10.1016/j.ejpain.2009.10.005 – volume: 42 start-page: 717 issue: 2 year: 2008 ident: pone.0267170.ref030 article-title: More accurate Talairach coordinates for neuroimaging using non-linear registration. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.04.240 – volume: 6 start-page: 13 issue: 1 year: 2001 ident: pone.0267170.ref049 article-title: The amygdala: vigilance and emotion. publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4000812 – volume: 221 start-page: 117164 year: 2020 ident: pone.0267170.ref023 article-title: NeuroImage Sample size evolution in neuroimaging research: An evaluation of highly-cited studies (1990–2012) and of latest practices (2017–2018) in high-impact journals. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2020.117164 – volume: 35 start-page: 527 issue: 2 year: 2014 ident: pone.0267170.ref036 article-title: The Human Amygdala and Pain: Evidence From Neuroimaging. publication-title: Hum Brain Mapp doi: 10.1002/hbm.22199 – volume: 157 start-page: 1194 year: 2016 ident: pone.0267170.ref016 article-title: Mesolimbic dopamine signaling in acute and chronic pain: Implications for motivation, analgesia, and addiction publication-title: Pain doi: 10.1097/j.pain.0000000000000494 – volume: 17 start-page: 52 issue: 1 year: 2001 ident: pone.0267170.ref017 article-title: Theoretical perspectives on the relation between catastrophizing and pain publication-title: Clin J Pain doi: 10.1097/00002508-200103000-00008 – volume: 45 start-page: 169 issue: 1 year: 2009 ident: pone.0267170.ref037 article-title: Brain activity associated with the electrodermal reactivity to acute heat pain publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.10.024 – volume: 37 start-page: 249 issue: 4 year: 2007 ident: pone.0267170.ref039 article-title: Central representation of the RIII flexion reflex associated with overt motor reaction: An fMRI study. publication-title: Neurophysiol Clin. doi: 10.1016/j.neucli.2007.07.002 – year: 2021 ident: pone.0267170.ref067 article-title: Human ventromedial prefrontal cortex lesions enhance expectation-related pain modulation publication-title: bioRxiv – volume: 55 start-page: 970 issue: 6 year: 2007 ident: pone.0267170.ref054 article-title: Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala publication-title: Neuron doi: 10.1016/j.neuron.2007.08.004 – volume: 43 start-page: 486 issue: 4 year: 2016 ident: pone.0267170.ref001 article-title: Individual and sex-related differences in pain and relief responsiveness are associated with differences in resting-state functional networks in healthy volunteers publication-title: Eur J Neurosci doi: 10.1111/ejn.13125 – volume: 25 start-page: 109 issue: 2 year: 2012 ident: pone.0267170.ref043 article-title: New developments in the understanding and management of persistent pain publication-title: Curr Opin Psychiatry doi: 10.1097/YCO.0b013e3283503510 – volume: 56 start-page: 1137 issue: 2 year: 2018 ident: pone.0267170.ref068 article-title: Role of the Prefrontal Cortex in Pain Processing publication-title: Mol Neurobiol doi: 10.1007/s12035-018-1130-9 – volume: 14 start-page: 1 issue: 8 year: 2019 ident: pone.0267170.ref021 article-title: Aberrant resting-state functional connectivity of the dorsolateral prefrontal cortex to the anterior insula and its association with fear avoidance belief in chronic neck pain patients publication-title: PLoS One doi: 10.1371/journal.pone.0221023 – volume: 95 start-page: 1536 issue: 11 year: 2015 ident: pone.0267170.ref034 article-title: Clinical Ratings of Pain Sensitivity Correlate With Quantitative Measures in People With Chronic Neck Pain and Healthy Controls: Cross-Sectional Study publication-title: Phys Ther doi: 10.2522/ptj.20140352 – volume: 19 start-page: 2209 issue: 10 year: 2009 ident: pone.0267170.ref076 article-title: The resting brain: Unconstrained yet reliable publication-title: Cereb Cortex doi: 10.1093/cercor/bhn256 – volume: 23 start-page: 727 issue: 4–5 year: 2003 ident: pone.0267170.ref042 article-title: The emotional brain, fear, and the amygdala publication-title: Cell Mol Neurobiol doi: 10.1023/A:1025048802629 – volume: 59 start-page: 648 issue: 4 year: 2008 ident: pone.0267170.ref057 article-title: Basolateral Amygdala Neurons Facilitate Reward-Seeking Behavior by Exciting Nucleus Accumbens Neurons publication-title: Neuron doi: 10.1016/j.neuron.2008.07.004 – volume: 9 start-page: 463 issue: 4 year: 2005 ident: pone.0267170.ref025 article-title: Human brain mechanisms of pain perception and regulation in health and disease publication-title: Eur J Pain doi: 10.1016/j.ejpain.2004.11.001 – volume: 30 start-page: 363 year: 2019 ident: pone.0267170.ref041 article-title: Abnormal amygdala resting-state functional connectivity in primary dysmenorrhea. publication-title: NeuroReport: For Rapid Communication of Neuroscience Research. doi: 10.1097/WNR.0000000000001208 – volume: 202 year: 2019 ident: pone.0267170.ref005 article-title: Identifying inter-individual differences in pain threshold using brain connectome: a test-retest reproducible study. publication-title: Neuroimage – volume: 15 start-page: 1117 issue: 8 year: 2012 ident: pone.0267170.ref032 article-title: Corticostriatal functional connectivity predicts transition to chronic back pain publication-title: Nat Neurosci doi: 10.1038/nn.3153 – volume: 24 start-page: 7199 year: 2004 ident: pone.0267170.ref070 article-title: Perceived Controllability Modulates the Neural Response to Pain publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.1315-04.2004 – volume: 24 start-page: 580 issue: 3 year: 2020 ident: pone.0267170.ref065 article-title: Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity publication-title: Eur J Pain doi: 10.1002/ejp.1510 – volume: 17 start-page: 1304 year: 2014 ident: pone.0267170.ref052 article-title: Reward and motivation in pain and pain relief publication-title: Nature Neuroscience doi: 10.1038/nn.3811 – volume: 125 start-page: 1326 year: 2002 ident: pone.0267170.ref038 article-title: Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: A single-trial fMRI study publication-title: Brain doi: 10.1093/brain/awf137 – volume: 139 start-page: 1958 issue: 7 year: 2016 ident: pone.0267170.ref033 article-title: Corticolimbic anatomical characteristics predetermine risk for chronic pain publication-title: Brain doi: 10.1093/brain/aww100 – volume: 15 start-page: 252 issue: 3 year: 1996 ident: pone.0267170.ref013 article-title: Effects of oral morphine on cold presser tolerance time and neuropsychological performance publication-title: Neuropsychopharmacology doi: 10.1016/0893-133X(95)00205-R – volume: 5 start-page: 844 issue: 11 year: 2004 ident: pone.0267170.ref053 article-title: Neuronal signalling of fear memory. publication-title: Nat Rev Neurosci doi: 10.1038/nrn1535 – volume: 7 year: 2013 ident: pone.0267170.ref074 article-title: Physiological Noise in Brainstem fMRI. publication-title: Front Hum Neurosci. – volume: 8 start-page: 1 issue: 1 year: 2015 ident: pone.0267170.ref045 article-title: The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice publication-title: Mol Brain doi: 10.1186/s13041-015-0108-z – volume: 24 start-page: 148 issue: 1 year: 2012 ident: pone.0267170.ref051 article-title: Amygdalar Function Reflects Common Individual Differences in Emotion and Pain Regulation Success. publication-title: J Cogn Neurosci doi: 10.1162/jocn_a_00125 – volume: 702 start-page: 15 year: 2019 ident: pone.0267170.ref031 article-title: Cortico-limbic pain mechanisms publication-title: Neurosci Lett doi: 10.1016/j.neulet.2018.11.037 – volume: 24 start-page: 235 issue: 1 year: 2005 ident: pone.0267170.ref050 article-title: A direct brainstem–amygdala–cortical ‘alarm’ system for subliminal signals of fear. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.08.016 – start-page: 449 year: 2006 ident: pone.0267170.ref059 article-title: A motivation-decision model of pain: The role of opioids publication-title: Proc 11th world Congr pain. – volume: 7 start-page: 21 issue: 1 year: 2002 ident: pone.0267170.ref073 article-title: Effects of Emotion on Pain Reports, Tolerance and Physiology. publication-title: Pain Res Manag. doi: 10.1155/2002/426193 – volume: 11 start-page: 1 issue: 1 year: 2020 ident: pone.0267170.ref004 article-title: Pain-free resting-state functional brain connectivity predicts individual pain sensitivity publication-title: Nat Commun doi: 10.1038/s41467-019-13785-z – volume: 8 start-page: 31 issue: 1 year: 2004 ident: pone.0267170.ref020 article-title: The tridimensional personality theory and pain: harm avoidance and reward dependence traits correlate with pain perception in healthy volunteers publication-title: Eur J Pain doi: 10.1016/S1090-3801(03)00065-X – volume: 107 start-page: 355 issue: 1 year: 2010 ident: pone.0267170.ref003 article-title: Prestimulus Functional Connectivity Determines Pain Perception in Humans publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0906186106 – volume: 18 start-page: 464 issue: 4 year: 2008 ident: pone.0267170.ref061 article-title: Pain perception in relation to emotional learning publication-title: Curr Opin Neurobiol doi: 10.1016/j.conb.2008.09.012 – volume: 26 start-page: 3508 issue: 8 year: 2016 ident: pone.0267170.ref029 article-title: The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture publication-title: Cereb Cortex doi: 10.1093/cercor/bhw157 – volume: 1 start-page: 9 year: 2013 ident: pone.0267170.ref048 article-title: The amygdala between sensation and affect: a role in pain publication-title: Journal of molecular psychiatry doi: 10.1186/2049-9256-1-9 – volume: 24 start-page: 2923 year: 2004 ident: pone.0267170.ref055 article-title: The Ventral Tegmental Area is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.5282-03.2004 – volume: 158 start-page: 212 issue: 2 year: 2017 ident: pone.0267170.ref063 article-title: Brain substrates of reward processing and the μ-opioid receptor: A pathway into pain? publication-title: Pain doi: 10.1097/j.pain.0000000000000720 – volume: 44 start-page: 227 year: 2005 ident: pone.0267170.ref019 article-title: The short-form version of the Depression Anxiety Stress Scales (DASS-21): Construct validity and normative data in a large non-clinical sample. publication-title: Br J Clin Psychol doi: 10.1348/014466505X29657 – volume: 75 start-page: 68 year: 2013 ident: pone.0267170.ref002 article-title: Intrinsic variability in the human response to pain is assembled from multiple, dynamic brain processes. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2013.02.028 – year: 2014 ident: pone.0267170.ref009 article-title: Sub-Grouping Healthy Subjects’ Sensitivity to Pain and Its Relationship to Personality Traits: Results of a Cluster Analysis publication-title: Appl Math – volume: 21 start-page: 439 issue: 5 year: 2005 ident: pone.0267170.ref018 article-title: The roles of pain catastrophizing and anxiety in the prediction of postoperative pain intensity: A prospective study publication-title: Clin J Pain doi: 10.1097/01.ajp.0000135236.12705.2d – volume: 157 start-page: 1970 year: 2016 ident: pone.0267170.ref007 article-title: Perturbed connectivity of the amygdala and its subregions with the central executive and default mode networks in chronic pain publication-title: Pain doi: 10.1097/j.pain.0000000000000606 – volume: 34 start-page: 109 issue: 1 year: 2013 ident: pone.0267170.ref027 article-title: Localization of pain-related brain activation: A meta-analysis of neuroimaging data publication-title: Hum Brain Mapp doi: 10.1002/hbm.21416 – volume: 23 start-page: 31 issue: 1 year: 1992 ident: pone.0267170.ref014 article-title: Differences in cognitive coping strategies among pain-sensitive and pain-tolerant individuals on the cold-pressor test. publication-title: Behav Ther doi: 10.1016/S0005-7894(05)80306-5 – volume: 136 start-page: 2751 year: 2013 ident: pone.0267170.ref064 article-title: Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits publication-title: Brain doi: 10.1093/brain/awt211 – volume: 14 start-page: 126 issue: 3 year: 2014 ident: pone.0267170.ref075 article-title: Two-Week Test-Retest Stability of the Cold Pressor Task Procedure at two different Temperatures as a Measure of Pain Threshold and Tolerance publication-title: Pain Pract doi: 10.1111/papr.12142 – volume: 155 start-page: 1659 issue: 8 year: 2014 ident: pone.0267170.ref056 article-title: Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy publication-title: Pain doi: 10.1016/j.pain.2014.05.018 – volume: 191 start-page: 521 issue: 3 year: 2007 ident: pone.0267170.ref058 article-title: The nucleus accumbens as part of a basal ganglia action selection circuit publication-title: Psychopharmacology (Berl). doi: 10.1007/s00213-006-0510-4 |
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| Snippet | The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs... Background The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological... Background The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological... |
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| SubjectTerms | Affect (Psychology) Alertness Amygdala Amygdala - physiology Analysis Anxiety Biology and Life Sciences Brain Brain - diagnostic imaging Brain Mapping Care and treatment Cerebral hemispheres Cognitive ability Cold Functional magnetic resonance imaging Health sciences Heat Heat shock proteins Humans Magnetic Resonance Imaging Medicine and Health Sciences Mental depression Mental health Neural circuitry Neural networks Neural Pathways - physiology Neurosciences Nucleus accumbens Pain Pain - diagnostic imaging Pain perception Pain sensitivity Perceptions Psychological factors Questionnaires Social Sciences Stress Withdrawal |
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| Title | Increased functional connectivity between limbic brain areas in healthy individuals with high versus low sensitivity to cold pain: A resting state fMRI study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35442971 https://www.proquest.com/docview/2652847512 https://www.proquest.com/docview/2653269254 https://pubmed.ncbi.nlm.nih.gov/PMC9020745 https://doaj.org/article/5b145d0a1f5b410d91b140b82345eb08 http://dx.doi.org/10.1371/journal.pone.0267170 |
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