Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation

• Published in: PloS one Vol. 12; no. 12; p. e0187771
• Main Authors: Koparde, Vishal, Abdul Razzaq, Badar, Suntum, Tara, Sabo, Roy, Scalora, Allison, Serrano, Myrna, Jameson-Lee, Max, Hall, Charles, Kobulnicky, David, Sheth, Nihar, Feltz, Juliana, Contaifer, Daniel, Wijesinghe, Dayanjan, Reed, Jason, Roberts, Catherine, Qayyum, Rehan, Buck, Gregory, Neale, Michael, Toor, Amir
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2017; Public Library of Science (PLoS)
• Subjects: Analysis; Antigens; Binding; Biology and Life Sciences; Bone marrow; Cancer; Cell Transplantation; Clinical outcomes; Computer and Information Sciences; Computer simulation; Cytotoxicity; Dynamical systems; Exome sequencing; Genetic aspects; Graft-versus-host reaction; Histocompatibility antigen HLA; Humans; Incidence; Internal medicine; Leukemia; Lymphocytes; Lymphocytes T; Mathematical analysis; Matrix algebra; Matrix methods; Medicine; Medicine and Health Sciences; Minor histocompatibility antigens; Models, Theoretical; Peptides; Peptides - immunology; Pharmacy; Physical Sciences; Physiological aspects; Proteins; Randomness; Research and Analysis Methods; Sequences; Single-nucleotide polymorphism; Stem Cell Transplantation; Stem cells; T cells; T-Lymphocytes - immunology; Transplantation; Transplants & implants; Whole Exome Sequencing; United States; United States > US; Virginia

Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (...