Gene Expression in Peripheral Immune Cells following Cardioembolic Stroke Is Sexually Dimorphic

• Published in: PloS one Vol. 9; no. 7; p. e102550
• Main Authors: Stamova, Boryana, Jickling, Glen C., Ander, Bradley P., Zhan, Xinhua, Liu, DaZhi, Turner, Renee, Ho, Carolyn, Khoury, Jane C., Bushnell, Cheryl, Pancioli, Arthur, Jauch, Edward C., Broderick, Joseph P., Sharp, Frank R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.07.2014; Public Library of Science (PLoS)
• Subjects: Age; Aged; Aged, 80 and over; Apoptosis; B cells; Biology and Life Sciences; Blood; Blood cells; Cardiac arrhythmia; Cell death; Cell survival; Comparative analysis; DNA microarrays; Emergency medical care; Epidemiology; Erythroblasts - metabolism; Female; Females; Gender differences; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genes; Genetic research; Genomes; Health risks; Heart Diseases - complications; Humans; Immune response; Immune system; Inflammation - genetics; Intracranial Embolism - blood; Intracranial Embolism - etiology; Intracranial Embolism - genetics; Intracranial Embolism - immunology; Ischemia; Leukocytes; Leukocytes - metabolism; Male; Males; Medicine and Health Sciences; Megakaryocytes - metabolism; Middle Aged; Molecular Sequence Data; Monocytes - metabolism; Nervous system; Neurology; Neutrophils; Neutrophils - metabolism; Pathogenesis; Risk analysis; Risk factors; Risk management; RNA; Sex; Sex Characteristics; Sexual dimorphism; Signaling; Stroke; Time Factors; Transcription Factors - metabolism; Vascular diseases; Sacramento California; Ohio; California; United States > US

Epidemiological studies suggest that sex has a role in the pathogenesis of cardioembolic stroke. Since stroke is a vascular disease, identifying sexually dimorphic gene expression changes in blood leukocytes can inform on sex-specific risk factors, response and outcome biology. We aimed to examine t...