Increase in Red Blood Cell-Nitric Oxide Synthase Dependent Nitric Oxide Production during Red Blood Cell Aging in Health and Disease: A Study on Age Dependent Changes of Rheologic and Enzymatic Properties in Red Blood Cells - Bizjak, Daniel Alexander; Brinkmann, Christian; Bloch, Wilhelm; Grau, Marijke (PloS one, 2015)
Keywords: Activation; Adult; Age; Aging; Arginase; Arginase - metabolism; Arginine; Bioavailability; Biomarkers - metabolism; Blood; Blood cells; Cell size; Centrifugation; Centrifugation, Density Gradient; Deformability; Density gradients; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Enzyme Inhibitors - pharmacology; Enzymes; Erythrocyte Aging - drug effects; Erythrocyte Deformability - drug effects; Erythrocyte Volume - drug effects; Erythrocytes; Erythrocytes - enzymology; Formability; Health; Hemorheology - drug effects; Humans; Hypoxia; In vivo methods and tests; Linear Models; Medical research; Medicine; Metabolism; Metabolome - drug effects; Nitric oxide; Nitric Oxide - biosynthesis; Nitric Oxide Synthase - metabolism; Nitric-oxide synthase; Nitrites - metabolism; Ornithine; Ornithine - analogs & derivatives; Ornithine - pharmacology; Phosphatidylserines - metabolism; Phosphorylation; Rheological properties; Rodents; Senescence; Shrinkage; Subpopulations; Substrates; Type 2 diabetes; United States--US; Germany