Estimation of Activity Related Energy Expenditure and Resting Metabolic Rate in Freely Moving Mice from Indirect Calorimetry Data

• Published in: PloS one Vol. 7; no. 5; p. e36162
• Main Authors: Van Klinken, Jan Bert, van den Berg, Sjoerd A. A., Havekes, Louis M., Willems Van Dijk, Ko
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.05.2012; Public Library of Science (PLoS)
• Subjects: Accuracy; Analysis; Animals; Basal Metabolism; Biology; Body weight; Calorimetry; Calorimetry - methods; Case studies; Computer applications; Computer simulation; Dilution; Energy; Energy expenditure; Estimates; Exercise; Female; Heat measurement; High fat diet; Internal medicine; Kalman filter; Kalman filters; Laboratory animals; Male; Mathematics; Medicine; Metabolic rate; Metabolism; Mice; Mice, Inbred C57BL; Motor Activity - physiology; Nutrition; Obesity; Physical activity; Physical fitness; Physiology; Pulmonary Gas Exchange; Regression; Regression Analysis; Reproducibility of Results; Robustness (mathematics); Rodents; Signal processing; Thermogenesis; Time dependence; Time Factors; Variables; Weight control; Netherlands

Physical activity (PA) is a main determinant of total energy expenditure (TEE) and has been suggested to play a key role in body weight regulation. However, thus far it has been challenging to determine what part of the expended energy is due to activity in freely moving subjects. We developed a com...