Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment - Trojani, Alessandra; Pungolino, Ester; Dal Molin, Alessandra; Lodola, Milena; Rossi, Giuseppe; D’Adda, Mariella; Perego, Alessandra; Elena, Chiara; Turrini, Mauro; Borin, Lorenza; Bucelli, Cristina; Malato, Simona; et al. (PloS one, 2019)
Keywords: 1-Phosphatidylinositol 3-kinase; ABC transporters; AKT protein; Antineoplastic agents; ATP-Binding Cassette Transporters - blood; Biochemistry; Biology and Life Sciences; Bone marrow; Cancer therapies; CD34 antigen; Cell cycle; Cell Cycle - drug effects; Cell differentiation; Cell growth; Cell proliferation; Cellular signal transduction; Chromosome replication; Chromosomes; Chronic myeloid leukemia; Clustering; Complications and side effects; Criminal investigation; Deoxyribonucleic acid; Deregulation; Diagnosis; Disease; DNA; DNA biosynthesis; DNA damage; DNA microarrays; DNA probes; DNA replication; Dosage and administration; Drug resistance; Drug therapy; Enzyme inhibitors; Female; Gene expression; Gene Expression Regulation, Leukemic - drug effects; Genes; Genetic aspects; Genomes; Hematology; Hospitals; Humans; Inhibitor drugs; Interleukin 7; Internal medicine; Janus kinase 2; Janus Kinases - blood; Kinases; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood; Male; MAP kinase; Medicine and Health Sciences; Middle Aged; Myeloid leukemia; Neoplasm Proteins - blood; Nilotinib; Phenols (Class of compounds); Phenotypes; Physiological aspects; Protein-tyrosine kinase; Proteins; Pyrimidines - administration & dosage; Replication; Research and analysis methods; Ruxolitinib; Signal transduction; Signal Transduction - drug effects; Signaling; STAT Transcription Factors - blood; Stem cells; Targeted cancer therapy; Time Factors; Tyrosine; Italy