No Association of Coffee Consumption with Gastric Ulcer, Duodenal Ulcer, Reflux Esophagitis, and Non-Erosive Reflux Disease: A Cross-Sectional Study of 8,013 Healthy Subjects in Japan

• Published in: PloS one Vol. 8; no. 6; p. e65996
• Main Authors: Shimamoto, Takeshi, Yamamichi, Nobutake, Kodashima, Shinya, Takahashi, Yu, Fujishiro, Mitsuhiro, Oka, Masashi, Mitsushima, Toru, Koike, Kazuhiko
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.06.2013; Public Library of Science (PLoS)
• Subjects: Acids; Adult; Adults; Age; Age Factors; Alcohol; Alcohol Drinking; Alcohol use; Alcoholic beverages; Analysis; Biology; Body mass; Body Mass Index; Body size; Caffeine; Coffee; Coffee - adverse effects; Consumption; Consumption data; Correlation analysis; Cross-Sectional Studies; Disease; Disorders; Duodenal ulcer; Duodenal Ulcer - epidemiology; Duodenal Ulcer - etiology; Endoscopes; Endoscopy; Epidemiology; Esophagitis; Esophagitis, Peptic - epidemiology; Esophagitis, Peptic - etiology; Esophagus; Family medical history; Female; Gastroenterology; Gastroesophageal reflux; Gastrointestinal diseases; Gastrointestinal tract diseases; Health risk assessment; Helicobacter Infections - epidemiology; Helicobacter pylori; Humans; Infections; Japan - epidemiology; Male; Medical research; Medicine; Medicine, Experimental; Meta-analysis; Multivariate analysis; Pepsinogen A - metabolism; Pepsinogen C - metabolism; Questionnaires; Regression analysis; Regurgitation; Risk Factors; Secretion; Sex Factors; Smoking; Stomach ulcer; Stomach Ulcer - epidemiology; Stomach Ulcer - etiology; Studies; Ulcers; Japan

Probably due to caffeine-induced gastric acid secretion, negative effects of coffee upon various upper-gastrointestinal diseases have been precariously accepted, despite the inadequate epidemiological evidence. Our aim is to evaluate the effect of coffee consumption on four major acid-related diseas...