The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells

• Published in: Journal of allergy and clinical immunology Vol. 135; no. 4; pp. 1044 - 1052.e5
• Main Authors: Weng, Zuyi, Patel, Arti B., Panagiotidou, Smaro, Theoharides, Theoharis C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015; Elsevier Limited
• Subjects: Allergy; Allergy and Immunology; Antibodies, Anti-Idiotypic - immunology; Asthma; calcium; Calcium - metabolism; Capillary Permeability - drug effects; Cell Degranulation - drug effects; Cell Degranulation - immunology; Cells, Cultured; Chemokine CCL2 - metabolism; Flavones - pharmacology; Gene Expression Regulation - drug effects; Hexosaminidases - metabolism; Human subjects; Humans; Immunoglobulin E - immunology; inflammation; luteolin; Luteolin - pharmacology; mast cells; Mast Cells - drug effects; Mast Cells - immunology; Mast Cells - metabolism; Neuropeptides; NF-kappa B - antagonists & inhibitors; NF-kappa B - metabolism; nuclear factor κB; Rodents; Stem cells; tetramethoxyluteolin; Tumor Necrosis Factors - metabolism; PGD2; Allergy; calcium; nuclear factor κB; hCBMC; DMSO; tetramethoxyluteolin; mast cells; IκBα; luteolin; DNP-HSA; NF-κB; Methlut; inflammation; MC; rhSCF; CCL2; SP; Dinitrophenol–human serum albumin; 3′,4′,5,7-Tetramethoxyluteolin; Chemokine (C-C motif) ligand 2; Human cord blood–derived mast cell; Nuclear factor κB inhibitor α; Recombinant human stem cell factor; Substance P; Prostaglandin D2; Dimethyl sulfoxide; Mast cell

Mast cells (MCs) are hematopoietic cells that mature in tissues and are involved in allergy, immunity, and inflammation by secreting multiple mediators. The natural flavone luteolin has anti-inflammatory actions and inhibits human mast cells (MCs). We sought to investigate the ability of luteolin an...