Mucosal immunity of mannose-modified chitosan microspheres loaded with the nontyepable Haemophilus influenzae outer membrane protein P6 in BALB/c mice

• Published in: PloS one Vol. 17; no. 6; p. e0269153
• Main Authors: Ma, Yushuai, Zhao, Ying, Chen, Rui, Sun, Wanru, Zhang, Yanxia, Qiao, Haixia, Chang, Yueli, Kang, Shaoping, Zhang, Yutuo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.06.2022; Public Library of Science (PLoS)
• Subjects: Amination; Amino acids; Antibiotics; Antigen presentation; Antigens; Bacterial proteins; Biology and Life Sciences; Care and treatment; CD4 antigen; CD8 antigen; Cell-mediated immunity; Chitin; Chitosan; Chronic obstructive pulmonary disease; Cytotoxicity; Drug delivery systems; Drugs; E coli; Ear diseases; Experiments; Haemophilus influenzae; Health aspects; Helper cells; Hemophilus infections; Immune response; Immune response (humoral); Immune system; Immunity; Immunization; Infections; Laboratory animals; Lung diseases; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Mannose; Medicine and Health Sciences; Membrane proteins; Membranes; Microspheres; Morbidity; Mucosal immunity; Nasopharynx; Obstructive lung disease; Opportunist infection; Otitis media; Pathogens; Pharmaceutical research; Physical Sciences; Pneumonia; Protein P6; Proteins; Respiratory tract infections; Sodium; Toxicity; Tripolyphosphate; Vaccines; Vehicles; China; Beijing China; Sweden; United States > US

Nontypeable Haemophilus influenzae (NTHi) is a common opportunistic pathogen that colonizes the nasopharynx. NTHi infections result in enormous global morbidity in two clinical settings: otitis media in children and acute exacerbation of chronic obstructive pulmonary disease (COPD) in adults. Thus,...