Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals - Briviba, Monta; Silamikelis, Ivars; Kalnina, Ineta; Ansone, Laura; Rovite, Vita; Elbere, Ilze; Radovica-Spalvina, Ilze; Fridmanis, Davids; Aladyeva, Jekaterina; Konrade, Ilze; Pirags, Valdis; Klovins, Janis (PloS one, 2019)
Keywords: Adult; Analysis; Antidiabetics; Beta2 protein; Biological markers; Biology and life sciences; Biomarkers; Biomedical research; Blood; Blood cells; Blood Cells - drug effects; Blood Cells - metabolism; Cancer; Carbon tetrachloride; Cell adhesion & migration; Cell cycle; Cholesterol; Clinical Trials as Topic; Computational Biology - methods; CXCR4 protein; Cytokines; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes therapy; DNA methylation; DQA1 protein; Drug dosages; Feces - chemistry; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation - drug effects; Gene regulation; Gene sequencing; Genes; Genomes; Health aspects; Healthy Volunteers; Hepatocyte nuclear factor 4; High-Throughput Nucleotide Sequencing; Histocompatibility antigen HLA; HLA antigens; Homeostasis; Humans; Immune response; Immune system; Immunoglobulin A; Insulin; Intestine; Kinases; Liver; Male; Medicine and Health Sciences; Metabolism; Metformin; Metformin - pharmacology; Middle Aged; Molecular Sequence Annotation; Next-generation sequencing; Peripheral blood; Receptors, Fc; Research and analysis methods; Ribonucleic acid; RNA; Studies; Target recognition; Transcription; Transcriptome; Type 2 diabetes; Young Adult; Latvia