Exposure to Electronic Cigarettes Impairs Pulmonary Anti-Bacterial and Anti-Viral Defenses in a Mouse Model

• Published in: PloS one Vol. 10; no. 2; p. e0116861
• Main Authors: Sussan, Thomas E., Gajghate, Sachin, Thimmulappa, Rajesh K., Ma, Jinfang, Kim, Jung-Hyun, Sudini, Kuladeep, Consolini, Nicola, Cormier, Stephania A., Lomnicki, Slawo, Hasan, Farhana, Pekosz, Andrew, Biswal, Shyam
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.02.2015; Public Library of Science (PLoS)
• Subjects: Alveoli; Analysis; Animal models; Animals; Antibacterial agents; Antiinfectives and antibacterials; Antimicrobial agents; Antiviral agents; Bacteria; Bacterial infections; Chronic obstructive pulmonary disease; Cigarette smoking; Cotinine; Cytokines; Cytotoxicity; Electronic cigarettes; Environmental health; Exposure; Free radicals; Free Radicals - analysis; Gene expression; Health aspects; Health sciences; Immune clearance; Immune response; Immune system; In vivo methods and tests; Infections; Inflammation; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype - physiology; Inhalation; Lung - drug effects; Lung - immunology; Lung - microbiology; Lung - virology; Lungs; Macrophages; Male; Marketing; Mice; Mice, Inbred C57BL; Microorganisms; Nicotine; Nicotine - adverse effects; Nicotine - chemistry; Oxidative stress; Oxidative Stress - drug effects; Perception; Phagocytosis; Phagocytosis - drug effects; Pneumonia; Public health; Respiration; Smoking; Smoking - adverse effects; Smoking cessation; Streptococcus infections; Streptococcus pneumoniae - physiology; Tobacco; Vapors; Viral infections; Viral Load - drug effects; Viruses; VOCs; Volatile organic compounds; Volatilization; Louisiana; Baton Rouge Louisiana; United States > US; Maryland; Baltimore Maryland

Electronic cigarettes (E-cigs) have experienced sharp increases in popularity over the past five years due to many factors, including aggressive marketing, increased restrictions on conventional cigarettes, and a perception that E-cigs are healthy alternatives to cigarettes. Despite this perception,...