Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans

• Published in: PloS one Vol. 10; no. 12; p. e0145085
• Main Authors: Hopkinson, Richard J, Leung, Ivanhoe K H, Smart, Tristan J, Rose, Nathan R, Henry, Luc, Claridge, Timothy D W, Schofield, Christopher J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.12.2015; Public Library of Science (PLoS)
• Subjects: Alcohol; Amino Acid Sequence; Aqueous solutions; Bacteria; Bacterial Proteins - chemistry; Bacterial Proteins - metabolism; Biochemistry; Carbon; Carbon-Sulfur Ligases - chemistry; Carbon-Sulfur Ligases - metabolism; Carcinogens; Catalysis; Chemistry; Dehydrogenases; Deoxyribonucleic acid; DNA; DNA repair; E coli; Enzymes; Escherichia coli; Formaldehyde; Formaldehyde-activating enzyme; Genetic aspects; Geometry; Glutathione; Glutathione - analogs & derivatives; Glutathione - metabolism; Iron; Laboratories; Mass spectrometry; Mass spectroscopy; Metabolism; Microbial metabolism; Molecular biology; Molecular Sequence Data; NMR; Nuclear magnetic resonance; Paracoccus denitrificans - enzymology; Physiological aspects; Pollutants; Proteins; RNA polymerase; Spectroscopy; Studies; United Kingdom; United Kingdom > UK

Formaldehyde is a toxin and carcinogen that is both an environmental pollutant and an endogenous metabolite. Formaldehyde metabolism, which is probably essential for all aerobic cells, likely proceeds via multiple mechanisms, including via a glutathione-dependent pathway that is widely conserved in...