Neuroimaging Analysis of the Dopamine Basis for Apathetic Behaviors in an MPTP-Lesioned Primate Model

• Published in: PloS one Vol. 10; no. 7; p. e0132064
• Main Authors: Tian, LinLin, Xia, Yuanxuan, Flores, Hubert P., Campbell, Meghan C., Moerlein, Stephen M., Perlmutter, Joel S.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.07.2015; Public Library of Science (PLoS)
• Subjects: Animal behavior; Animals; Apathy; Apathy - physiology; Behavior; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Correlation analysis; Cortex (insular); Diagnostic imaging; Dopamine; Dopamine - physiology; Dopamine receptors; Dopamine transporter; Dopaminergic Neurons - diagnostic imaging; Dopaminergic Neurons - pathology; Emotional behavior; Goals; Image processing; Infusion; Macaca fascicularis; Macaca nemestrina; Magnetic resonance; Magnetic Resonance Imaging; Male; Medical imaging; Monkeys; Motor Activity; Movement disorders; MPTP; Neurobiology; Neurodegenerative diseases; Neuroimaging; Neurology; Neurosciences; Neurotoxins; NMR; Nuclear magnetic resonance; Nucleus accumbens; Organ Specificity; Parkinson's disease; Parkinsonian Disorders - metabolism; Parkinsonian Disorders - pathology; Parkinsonian Disorders - psychology; Parkinsons disease; Phenols (Class of compounds); Positron emission; Positron emission tomography; Prefrontal cortex; Primates; Radiopharmaceuticals; Regression analysis; Single-Blind Method; Studies; Substantia nigra; Tomography; Transport buildings, stations and terminals; Transporter; Tropane; Tyrosine 3-Monooxygenase - analysis; Ventral tegmentum

Apathy commonly occurs in Parkinson disease (PD) patients; however, the role of dopamine in the pathophysiology of apathy remains elusive. We previously demonstrated that dopaminergic dysfunction within the ventral tegmental area (VTA)-nucleus accumbens (NAcc) pathway contributes to the manifestatio...