A vaccine using Anaplasma marginale subdominant type IV secretion system recombinant proteins was not protective against a virulent challenge

• Published in: PloS one Vol. 15; no. 2; p. e0229301
• Main Authors: Sarli, Macarena, Novoa, María B, Mazzucco, Matilde N, Signorini, Marcelo L, Echaide, Ignacio E, de Echaide, Susana T, Primo, María E
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.02.2020; Public Library of Science (PLoS)
• Subjects: Adjuvants; Anaplasma marginale; Anaplasma marginale - immunology; Anaplasma marginale - pathogenicity; Anaplasmosis; Animals; Antibodies, Bacterial - immunology; Bacterial Vaccines - genetics; Bacterial Vaccines - immunology; Biology and Life Sciences; Calves; Cattle; Cattle industry; Cell adhesion & migration; Cell size; Cloning; Deoxyribonucleic acid; Diseases; DNA; E coli; EDTA; Elongation; Erythrocytes; Escherichia coli; Immunization; Immunogenicity; Immunoglobulin G; Infections; Livestock; Medical research; Medicine and Health Sciences; Oxytetracycline; Pathogenic microorganisms; Pathogens; Plasmids; Protein expression; Proteins; Recombinant proteins; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Research and Analysis Methods; Saponins; Tick-borne diseases; Type IV Secretion Systems - genetics; Type IV Secretion Systems - immunology; Vaccination; Vaccines; Virulence - immunology; United States > US; Argentina

Anaplasma marginale is the most prevalent tick-borne livestock pathogen with worldwide distribution. Bovine anaplasmosis is a significant threat to cattle industry. Anaplasmosis outbreaks in endemic areas are prevented via vaccination with live A. centrale produced in splenectomized calves. Since A....