The Untranslated Regions of Classic Swine Fever Virus RNA Trigger Apoptosis

• Published in: PloS one Vol. 9; no. 2; p. e88863
• Main Authors: Hsu, Wei-Li, Chen, Chung-Lun, Huang, Shi-Wei, Wu, Chia-Chen, Chen, I-Hsuan, Nadar, Muthukumar, Su, Yin-Peng, Tsai, Ching-Hsiu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.02.2014; Public Library of Science (PLoS)
• Subjects: 3' Untranslated Regions; 5' Untranslated Regions; Amino acids; Analysis; Animals; Annexin A5 - metabolism; Apoptosis; Biology; Biotechnology; Caspase; Caspases - metabolism; Cell death; Cell Line; Chronic diseases; Chronic infection; Classical Swine Fever Virus - genetics; Cytokines; Cytometry; Deoxyribonucleic acid; DNA; DNA fragmentation; Dogs; Double-stranded RNA; Fever; Flow cytometry; Gene Expression Regulation, Viral; Genes; Genomes; Genomics; Health aspects; Hemorrhage; Hog cholera; Hogs; Humans; Infection; Infections; Interferon; Kinases; Livestock; Luciferase; Nucleotide sequence; Plasmids; Proteins; Public health; R&D; Rabbits; Research & development; Ribonucleic acid; RNA; RNA polymerase; RNA viruses; RNA, Double-Stranded - genetics; RNA, Double-Stranded - metabolism; RNA, Viral - genetics; RNA, Viral - metabolism; rRNA; Swine; Transfection; Translation; Translation (Genetics); Tumor necrosis factor-TNF; Veterinary Science; Viruses

Classical swine fever virus (CSFV) causes a broad range of disease in pigs, from acute symptoms including high fever and hemorrhages, to chronic disease or unapparent infection, depending on the virus strain. CSFV belongs to the genus Pestivirus of the family Flaviviridae. It carries a single-strand...