Determination of sRNA Expressions by RNA-seq in Yersinia pestis Grown In Vitro and during Infection

• Published in: PloS one Vol. 8; no. 9; p. e74495
• Main Authors: Yan, Yanfeng, Su, Shanchun, Meng, Xiangrong, Ji, Xiaolan, Qu, Yi, Liu, Zizhong, Wang, Xiaoyi, Cui, Yujun, Deng, Zhongliang, Zhou, Dongsheng, Jiang, Wencan, Yang, Ruifu, Han, Yanping
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.09.2013; Public Library of Science (PLoS)
• Subjects: Animals; Antisense RNA; Bacteria; Base Sequence; Culture Media; Epidemiology; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Gene Library; Gene regulation; Gene sequencing; Genomes; Genomics; Health aspects; High-Throughput Nucleotide Sequencing; Host Factor 1 Protein - genetics; Host Factor 1 Protein - metabolism; Infection; Infections; Laboratories; Lung - metabolism; Lung - microbiology; Lung - pathology; Lungs; Mice; Mice, Inbred BALB C; Molecular Sequence Annotation; Molecular Sequence Data; Next-generation sequencing; Pathogenesis; Pathogens; Plague - microbiology; Post-transcription; Protein binding; Pseudotuberculosis; Quantitative analysis; Ribonucleic acid; RNA; RNA, Small Untranslated - classification; RNA, Small Untranslated - genetics; RNA, Small Untranslated - metabolism; RNA-binding protein; Sequence Homology, Nucleic Acid; Transcription (Genetics); Virulence; Yersinia pestis; Yersinia pestis - genetics; Yersinia pestis - isolation & purification; Yersinia pestis - metabolism; Yersinia pestis - pathogenicity; Yersinia pseudotuberculosis; Yersinia pseudotuberculosis - genetics; Beijing China; China

Small non-coding RNAs (sRNAs) facilitate host-microbe interactions. They have a central function in the post-transcriptional regulation during pathogenic lifestyles. Hfq, an RNA-binding protein that many sRNAs act in conjunction with, is required for Y. pestis pathogenesis. However, information on h...