1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism Apa1 influence bone mineral density in primary hyperparathyroidism

• Published in: PloS one Vol. 8; no. 2; p. e56019
• Main Authors: Christensen, Monika H E, Apalset, Ellen M, Nordbø, Yngve, Varhaug, Jan Erik, Mellgren, Gunnar, Lien, Ernst A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.02.2013; Public Library of Science (PLoS)
• Subjects: 25-Hydroxyvitamin D; Adult; Aged; Alleles; Biology; Bone and Bones - physiopathology; Bone density; Bone Density - genetics; Bone mineral density; Bone turnover; Calcium; Calcium (blood); Calcium metabolism; Cross-Sectional Studies; Enzymes; Family medical history; Female; Femur; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genotype; Hormones; Hospitals; Humans; Hyperparathyroidism; Hyperparathyroidism, Primary - blood; Hyperparathyroidism, Primary - genetics; Hyperparathyroidism, Primary - physiopathology; Influence; Laboratories; Ligands; Male; Medical research; Medicine; Metabolism; Metabolites; Middle Aged; Parathyroid; Parathyroid hormone; Parathyroid hormones; Patients; Polymorphism; Polymorphism, Single Nucleotide; Prospective Studies; Radius; Receptors, Calcitriol - genetics; Serum levels; Skeleton; Spine; Spine (lumbar); Studies; Supplements; Surgery; Twins; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin deficiency; Womens health; Norway

Parathyroid hormone (PTH) and vitamin D are the most important hormones regulating calcium metabolism. In primary hyperparathyroidism (PHPT) excessive amounts of PTH are produced. Bone turnover is enhanced, leading to reduced bone mineral density and elevated levels of serum calcium. The aim of this...