SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression

• Published in: PloS one Vol. 8; no. 7; p. e69037
• Main Authors: Marathe, Himangi G, Mehta, Gaurav, Zhang, Xiaolu, Datar, Ila, Mehrotra, Aanchal, Yeung, Kam C, de la Serna, Ivana L
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.07.2013; Public Library of Science (PLoS)
• Subjects: Activation; Animals; ATP; ATPases; Binding sites; Biochemistry; Biology; BRG1 protein; Cancer; Cell cycle; Cell differentiation; Cell Line; Chromatin; Chromatin Immunoprecipitation; Chromatin remodeling; Chromosomal Proteins, Non-Histone; Deoxyribonucleic acid; Differentiation (biology); DNA; DNA Helicases - genetics; DNA Helicases - metabolism; Early Growth Response Protein 2 - genetics; Early Growth Response Protein 2 - metabolism; Ectopic expression; Enzymes; Fibroblasts; Flow Cytometry; Gene expression; Gene loci; Gene regulation; Genes; Immunoblotting; Krox-20 protein; Life sciences; Loci; Medicine; Melanocytes; Mice; Musculoskeletal system; Mutation; Myelin; Myelin basic protein; Myelin P0 protein; Myelin proteins; Myelin Sheath - genetics; Myelin Sheath - metabolism; Nervous system; Neural crest; Neural stem cells; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oligodendrocytes; Peripheral nervous system; Protein Binding; Proteins; Real-Time Polymerase Chain Reaction; Recruitment; Schwann cells; Sox10 protein; SOXE Transcription Factors - genetics; SOXE Transcription Factors - metabolism; Stem cells; Transcription; Transcription (Genetics); Transcription activation; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; United States > US; Ohio

SOX10 is a Sry-related high mobility (HMG)-box transcriptional regulator that promotes differentiation of neural crest precursors into Schwann cells, oligodendrocytes, and melanocytes. Myelin, formed by Schwann cells in the peripheral nervous system, is essential for propagation of nerve impulses. S...