Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors

• Published in: PloS one Vol. 9; no. 6; p. e99683
• Main Authors: Choe, Regine, Putt, Mary E., Carlile, Peter M., Durduran, Turgut, Giammarco, Joseph M., Busch, David R., Jung, Ki Won, Czerniecki, Brian J., Tchou, Julia, Feldman, Michael D., Mies, Carolyn, Rosen, Mark A., Schnall, Mitchell D., DeMichele, Angela, Yodh, Arjun G.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.06.2014; Public Library of Science (PLoS)
• Subjects: Adult; Astronomy; Biology and Life Sciences; Biomedical engineering; Blood; Blood flow; Breast cancer; Breast Neoplasms - blood supply; Cancer; Cancer therapies; Case-Control Studies; Chemotherapy; Confidence intervals; Engineering and Technology; Female; Health aspects; Hospitals; Humans; I.R. radiation; Infrared spectroscopy; Laboratories; Laser-Doppler Flowmetry - instrumentation; Laser-Doppler Flowmetry - methods; Mammography; Measurement; Medical imaging; Medical prognosis; Medicine and Health Sciences; Metabolism; Microvasculature; Microvessels - physiopathology; Middle Aged; Monitoring; Near infrared radiation; NMR; Nuclear magnetic resonance; Optics; Perfusion; Physical Sciences; Physics; Regional Blood Flow; Remission; Spectroscopy; Spectrum analysis; Studies; Surgery; Therapy; Tissues; Tumors
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0099683

Microvascular blood flow contrast is an important hemodynamic and metabolic parameter with potential to enhance in vivo breast cancer detection and therapy monitoring. Here we report on non-invasive line-scan measurements of malignant breast tumors with a hand-held optical probe in the remission geo...