Meta-Analysis Derived (MAD) Transcriptome of Psoriasis Defines the “Core” Pathogenesis of Disease

• Published in: PloS one Vol. 7; no. 9; p. e44274
• Main Authors: Tian, Suyan, Krueger, James G., Li, Katherine, Jabbari, Ali, Brodmerkel, Carrie, Lowes, Michelle A., Suárez-Fariñas, Mayte
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.09.2012; Public Library of Science (PLoS)
• Subjects: Algorithms; Analysis; Arteriosclerosis; Atherosclerosis; Biology; Biomarkers; Cardiovascular diseases; Computational Biology - methods; Data processing; Dermatology; Development; DNA methylation; DNA microarrays; Fatty acids; Gene expression; Gene Expression Profiling - methods; Genes; Genetic aspects; Genomes; Genomics; Humans; Immunology; Inflammation; Inflammatory diseases; Laboratories; Lipid Metabolism; Mathematics; Medicine; Meta-analysis; Metabolic disorders; Metabolic syndrome; Metabolism; Methods; Methylation; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis - methods; Pathogenesis; Psoriasis; Psoriasis - genetics; Psoriasis - metabolism; Psoriasis - physiopathology; R&D; Regularization; Research & development; Reviews; Rheumatoid arthritis; Signal Transduction; Signaling; Skin; Skin - metabolism; Skin diseases; Stem cells; Studies; Tissues; Transcription Factors - metabolism; Transcriptome; New York; United States > US; Pennsylvania

The cause of psoriasis, a common chronic inflammatory skin disease, is not fully understood. Microarray experiments have been widely used in recent years to identify genes associated with psoriasis pathology, by comparing expression levels of lesional (LS) with adjacent non-lesional (NL) skin. It is...