Contribution of Intestinal Barrier Damage, Microbial Translocation and HIV-1 Infection Status to an Inflammaging Signature

• Published in: PloS one Vol. 9; no. 5; p. e97171
• Main Authors: Steele, Amanda K., Lee, Eric J., Vestal, Brian, Hecht, Daniel, Dong, Zachary, Rapaport, Eric, Koeppe, John, Campbell, Thomas B., Wilson, Cara C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.05.2014; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Activation; Adolescent; Adult; Adults; Age; Aging; AIDS; Analysis; Bacteria - metabolism; Biology and life sciences; Biomarkers; Biomarkers - blood; Cardiovascular disease; Cardiovascular diseases; Cell activation; Cluster analysis; Clustering; Cytomegalovirus; Gene Expression Regulation; Geriatrics; Health aspects; Health risks; HIV; HIV Infections - blood; HIV Infections - complications; HIV-1 - physiology; Human immunodeficiency virus; Humans; Immune response; Infections; Inflammation; Inflammation - complications; Inflammation - immunology; Inflammation - microbiology; Inflammation - virology; Interleukin 6; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestine; Lipopolysaccharides; Lymphocytes T; Male; Medicine and Health Sciences; Microorganisms; Middle Aged; Movement; Older people; Phenotype; Risk; T cells; Translocation; Young Adult; United States > US; Colorado

Systemic inflammation is a characteristic of both HIV-1 infection and aging ("inflammaging"). Intestinal epithelial barrier damage (IEBD) and microbial translocation (MT) contribute to HIV-associated inflammation, but their impact on inflammaging remains unclear. Plasma biomarkers for IEBD...