Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial - Harrison, Stephen A.; Dennis, Andrea; Fiore, Martine M.; Kelly, Matt D.; Kelly, Catherine J.; Paredes, Angelo H.; Whitehead, Jennifer M.; Neubauer, Stefan; Traber, Peter G.; Banerjee, Rajarshi (PloS one, 2018)
Keywords: Aged; Anti-inflammatory agents; Biology and Life Sciences; Biomarkers; Care and treatment; Clinical trials; Collagen; Dosage and administration; Double-Blind Method; Drug dosages; Elasticity; Fatty liver; Female; Females; Fibrosis; Hepatology; Humans; Hypertension; Inflammation; Infusion; Iron; Liver; Liver - diagnostic imaging; Liver - drug effects; Liver cirrhosis; Liver Cirrhosis - diagnostic imaging; Liver Cirrhosis - drug therapy; Liver Cirrhosis - physiopathology; Liver diseases; Magnetic resonance; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical imaging; Medical treatment; Medicine; Medicine and Health Sciences; Middle Aged; NMR; Non-alcoholic Fatty Liver Disease - diagnostic imaging; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - physiopathology; Nuclear magnetic resonance; Pectins - therapeutic use; Protective Agents - therapeutic use; Randomization; Reproducibility; Research and Analysis Methods; Resonance; Risk factors; Statistical analysis; Stiffness; Systematic review; Treatment Outcome; Ultrasonic testing; Ultrasonography - methods; United Kingdom--UK; United States--US; Texas