Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning - Gutteridge, Alex; Rukstalis, J. Michael; Ziemek, Daniel; Tié, Mark; Ji, Lin; Ramos-Zayas, Rebeca; Nardone, Nancy A.; Norquay, Lisa D.; Brenner, Martin B.; Tang, Kim; McNeish, John D.; Rowntree, Rebecca K. (PloS one, 2013)
Keywords: Algorithms; Animals; Bioinformatics; Biology; Cell differentiation; Cell Differentiation - genetics; Cell Lineage - genetics; Cytokines; Developmental biology; Diabetes; Diabetes mellitus; Embryo cells; Embryogenesis; Embryonic development; Embryonic stem cells; Epigenetics; Gastroenterology; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Genes; Genomes; Genomics; Glucose Tolerance Test; Humans; Insulin; Insulin-Secreting Cells - cytology; Insulin-Secreting Cells - metabolism; Interleukin 6; Interleukin-6 - genetics; Interleukin-6 - metabolism; Islets of Langerhans - embryology; Islets of Langerhans - metabolism; Kinases; Maturation; Medicine; Metabolic disorders; Mice; MicroRNA; miRNA; Nkx2.2 protein; Pancreas; R&D; Reasoning; Research & development; Rodents; Stat3 protein; Stem cell transplantation; Stem cells; United States--US; Massachusetts