Cdx2 polymorphism affects the activities of vitamin D receptor in human breast cancer cell lines and human breast carcinomas

• Published in: PloS one Vol. 10; no. 4; p. e0124894
• Main Authors: Pulito, Claudio, Terrenato, Irene, Di Benedetto, Anna, Korita, Etleva, Goeman, Frauke, Sacconi, Andrea, Biagioni, Francesca, Blandino, Giovanni, Strano, Sabrina, Muti, Paola, Mottolese, Marcella, Falvo, Elisabetta
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.04.2015; Public Library of Science (PLoS)
• Subjects: Apoptosis; Biomarkers; Biotechnology; Breast cancer; Breast carcinoma; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; CDX2 protein; CDX2 Transcription Factor; Cell cycle; Cell growth; Cell Line, Tumor; Development and progression; Epidemiology; ErbB-2 protein; Estrogen receptors; Estrogens; Female; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genes; Genetic aspects; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; MCF-7 Cells; Medical prognosis; Metabolism; Metabolites; Pathology; Patients; Polymorphism; Polymorphism, Genetic; Receptors, Calcitriol - genetics; Retrospective Studies; Rodents; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Systematic review; Tumor cell lines; Tumors; Vitamin D; Vitamin D - pharmacology; Vitamin D receptors

Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). It regulates the action of hormone responsive genes and is involved in cell cycle regulation, differentiation and apoptosis. VDR is a critical component of the vitamin D pathway and different common single nu...