Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents

• Published in: PloS one Vol. 9; no. 1; p. e85271
• Main Authors: Pretorius, Etheresia, Bester, Janette, Vermeulen, Natasha, Lipinski, Boguslaw, Gericke, George S., Kell, Douglas B.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.01.2014; Public Library of Science (PLoS)
• Subjects: Aberration; Adolescent; Adult; Biology; Blood & organ donations; Blood banks; Blood donation; Blood donors; Chelating agents; Chelation; Child; Clioquinol; Clioquinol - therapeutic use; Deferoxamine - therapeutic use; Diabetes; Dietary fiber; Electron microscopy; Erythrocytes; Erythrocytes - drug effects; Erythrocytes - metabolism; Erythrocytes - pathology; Female; Ferritin; Ferritins - antagonists & inhibitors; Ferritins - blood; Fibrin; Fibrin - metabolism; Fibrin - ultrastructure; Free radicals; Genes; Hemochromatosis; Hemochromatosis - drug therapy; Hemochromatosis - metabolism; Hemochromatosis - pathology; Hemoglobin; Humans; Hydroxides; Hydroxyl Radical - antagonists & inhibitors; Hydroxyl Radical - metabolism; Hydroxyl radicals; Iron; Iron - metabolism; Iron Chelating Agents - therapeutic use; Male; Medicine; Microscopy, Electron, Scanning; Middle Aged; Morphology; Mutation; Pathology; Physiology; Platelet-Rich Plasma - chemistry; Red blood cells; Salicylic acid; Salicylic Acid - therapeutic use; Scanning electron microscopy; Selenious Acid - therapeutic use; Selenite; Sickle cell anemia; Sickle cell disease; Smear; Stroke; Thrombin; Thrombin - pharmacology; Up-Regulation

It is well-known that individuals with increased iron levels are more prone to thrombotic diseases, mainly due to the presence of unliganded iron, and thereby the increased production of hydroxyl radicals. It is also known that erythrocytes (RBCs) may play an important role during thrombotic events....